Information on EC 3.1.1.3 - triacylglycerol lipase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY hide
3.1.1.3
-
RECOMMENDED NAME
GeneOntology No.
triacylglycerol lipase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
triacylglycerol + H2O = diacylglycerol + a carboxylate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acetylation
-
-
carboxylic ester hydrolysis
hydrolysis
hydrolysis of carboxylic ester
transesterification
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Glycerolipid metabolism
-
-
lipid metabolism
-
-
Metabolic pathways
-
-
retinol biosynthesis
-
-
triacylglycerol degradation
-
-
SYSTEMATIC NAME
IUBMB Comments
triacylglycerol acylhydrolase
The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolysed.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-62-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
69 V
-
-
Manually annotated by BRENDA team
strain BD 413
-
-
Manually annotated by BRENDA team
strain CR9
-
-
Manually annotated by BRENDA team
strain MTCC 6816
-
-
Manually annotated by BRENDA team
strain RAG-1, LipA
-
-
Manually annotated by BRENDA team
strain LPB 4
-
-
Manually annotated by BRENDA team
strain LPB 4
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Alcaligenes ssp.
commercial product
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
ATGL gene
-
-
Manually annotated by BRENDA team
precursor; gene lip1
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
alkaline thermostable lipase
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain NCIM 1207
-
-
Manually annotated by BRENDA team
strain Tiegh
-
-
Manually annotated by BRENDA team
strain HN2-3
UniProt
Manually annotated by BRENDA team
strain HN2.3
-
-
Manually annotated by BRENDA team
strain C(7)
-
-
Manually annotated by BRENDA team
strain C71
-
-
Manually annotated by BRENDA team
strain BTS-3
-
-
Manually annotated by BRENDA team
strain MTCC-6375
-
-
Manually annotated by BRENDA team
strain MTCC 6824
-
-
Manually annotated by BRENDA team
strain MTCC 6824
-
-
Manually annotated by BRENDA team
precursor; strain 370, ATCC 9885, gene lipA
UniProt
Manually annotated by BRENDA team
strain AKG-1, isolated from soil samples collected from Kargil region
-
-
Manually annotated by BRENDA team
strain B26, Ca2+-independent lipase
-
-
Manually annotated by BRENDA team
strain B26, Ca2+-independent lipase
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain RSJ-1, thermostable alkaline lipase
-
-
Manually annotated by BRENDA team
strain Tp10A.1, thermostable lipase LipA
-
-
Manually annotated by BRENDA team
strain 168 BsL, gene lipA
-
-
Manually annotated by BRENDA team
strain FH5, isolated from tannery wastes
-
-
Manually annotated by BRENDA team
dimorphic yeast, gene ALIPI
Uniprot
Manually annotated by BRENDA team
i.e. Pseudomonas cepacia
Uniprot
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
fragment, LipA; strain RG2, gene lipA
SwissProt
Manually annotated by BRENDA team
fragment, LipA; strain RG2, gene lipA
SwissProt
Manually annotated by BRENDA team
strain GXU56
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Candida albicans ATCC 10231
-
-
-
Manually annotated by BRENDA team
Candida cyclindraceae
-
-
-
Manually annotated by BRENDA team
2 orfs: CpLIP1 and CpLIP2
SwissProt
Manually annotated by BRENDA team
Cephaloleia presignis
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
strain NCTC 543
-
-
Manually annotated by BRENDA team
strain NCTC 543
-
-
Manually annotated by BRENDA team
ATGL gene
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
var. Kitawasesoba, two isozymes LIP I and LIP II
-
-
Manually annotated by BRENDA team
Geobacillus sp.
-
-
-
Manually annotated by BRENDA team
Geobacillus sp. ARM
-
-
-
Manually annotated by BRENDA team
strain AB-1
-
-
Manually annotated by BRENDA team
strain MC 7, thermostable lipase
-
-
Manually annotated by BRENDA team
strain P1
SwissProt
Manually annotated by BRENDA team
strain BTL2
-
-
Manually annotated by BRENDA team
strain ID-1, 2 thermostable lipases A and B, BTID-A and BTID-B
-
-
Manually annotated by BRENDA team
strain YN isolated from desert soil in Egypt, gene lipA
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain Y05
-
-
Manually annotated by BRENDA team
Geotrichum marinum
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
gray mullet
-
-
Manually annotated by BRENDA team
adult male locusts
-
-
Manually annotated by BRENDA team
gypsy moth
-
-
Manually annotated by BRENDA team
strain MTCC 7526
-
-
Manually annotated by BRENDA team
strain MTCC 7526
-
-
Manually annotated by BRENDA team
New Zealand hoki
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
turkey
-
-
Manually annotated by BRENDA team
ATGL gene
UniProt
Manually annotated by BRENDA team
strain MTCC 7530
-
-
Manually annotated by BRENDA team
strain MTCC 7530
-
-
Manually annotated by BRENDA team
strain INIA 528
-
-
Manually annotated by BRENDA team
Micrococcus sp. INIA 528
strain INIA 528
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain H37Rv, diverse genes encoding lipases with lipY encoding the enzyme with the highest activity, overview
Uniprot
Manually annotated by BRENDA team
strain H37Rv, diverse genes encoding lipases with lipY encoding the enzyme with the highest activity, overview
Uniprot
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
no activity in Malassezia globosa
-
-
-
Manually annotated by BRENDA team
no activity in Marinovum algicola
-
-
-
Manually annotated by BRENDA team
no activity in Marinovum algicola ATCC 51442
-
-
-
Manually annotated by BRENDA team
no activity in Phaeobacter gallaeciensis BS107
-
-
-
Manually annotated by BRENDA team
cultivar Ogliarola
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Chinook salmon
-
-
Manually annotated by BRENDA team
Pachnoda sinuata flaviventris
adult male fruit beetles collected at Cape Town
-
-
Manually annotated by BRENDA team
Penicillium candidum
-
-
-
Manually annotated by BRENDA team
M1
-
-
Manually annotated by BRENDA team
precursor; strain PED-03 isolated from the waste of a rap oil manufactory in China
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
strain IAM7268
-
-
Manually annotated by BRENDA team
Penicillium wortmanii
-
-
-
Manually annotated by BRENDA team
adult male cockroaches
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
highly alkaline enzyme
-
-
Manually annotated by BRENDA team
strain TAC125
UniProt
Manually annotated by BRENDA team
strain TAC125
UniProt
Manually annotated by BRENDA team
strain wp27
-
-
Manually annotated by BRENDA team
strain wp27
-
-
Manually annotated by BRENDA team
strain 10145, ATCC
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain EF2
-
-
Manually annotated by BRENDA team
strain MTCC 5113 isolated from the soil
-
-
Manually annotated by BRENDA team
strain MTCC-2297
-
-
Manually annotated by BRENDA team
strain PAC 1R
-
-
Manually annotated by BRENDA team
strain PAC1R
-
-
Manually annotated by BRENDA team
strain PAO 2302, gene lip
-
-
Manually annotated by BRENDA team
strain Ps-x, two extracellular isozymes
-
-
Manually annotated by BRENDA team
strain PseA
-
-
Manually annotated by BRENDA team
strain YS-7
-
-
Manually annotated by BRENDA team
strain B52, gene lip
-
-
Manually annotated by BRENDA team
strain B68 isolated from soil samples of China, gene lipB68
SwissProt
Manually annotated by BRENDA team
strain HU380
-
-
Manually annotated by BRENDA team
strain SIK W1
-
-
Manually annotated by BRENDA team
22-39 B
-
-
Manually annotated by BRENDA team
strain IFO 3458, gene lips
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain PK-12CS, alkaline lipase
-
-
Manually annotated by BRENDA team
strain F-111, strain KKA-5
-
-
Manually annotated by BRENDA team
strain B11-1
-
-
Manually annotated by BRENDA team
strain KB700A
-
-
Manually annotated by BRENDA team
strain KM1-56
-
-
Manually annotated by BRENDA team
strain SW-3, lipase LipA or PLS, gene lipA
SwissProt
Manually annotated by BRENDA team
strain 7195
-
-
Manually annotated by BRENDA team
strain wp37
-
-
Manually annotated by BRENDA team
strain M1, gene lipA
-
-
Manually annotated by BRENDA team
strain M1, gene lipA
-
-
Manually annotated by BRENDA team
NR 400
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
fragment; strain WPG, noninduced lipase ROLw
SwissProt
Manually annotated by BRENDA team
CBS 5804, lipase I and II
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Serratia marcescens Sr41 8000
Sr41 8000
-
-
Manually annotated by BRENDA team
cv. Momotarou
-
-
Manually annotated by BRENDA team
strain FN 37
-
-
Manually annotated by BRENDA team
strain FN 37
-
-
Manually annotated by BRENDA team
strain RP 62A, strain 9
-
-
Manually annotated by BRENDA team
fragment of Ssp; strains 7108 and 9325, gene ssp
SwissProt
Manually annotated by BRENDA team
strain 863, SWL2, lipase 2
-
-
Manually annotated by BRENDA team
strain 863, SWL2, lipase 2
-
-
Manually annotated by BRENDA team
strain A3(2)
UniProt
Manually annotated by BRENDA team
strain A3(2)
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
ostrich
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Thermomyces lanuginosus No. 3
No. 3
-
-
Manually annotated by BRENDA team
strain DSM 11003, an anaerobic, thermophilic, alkali-tolerant bacterium
-
-
Manually annotated by BRENDA team
strain HB27
-
-
Manually annotated by BRENDA team
gene LIP
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain MTCC 6841, isolated from from lake Naukuchiatal, Uttaranchal state, India
-
-
Manually annotated by BRENDA team
strain MTCC 6841, isolated from from lake Naukuchiatal, Uttaranchal state, India
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
additional information
-
HDL particles in plasma are central to regulation of hepatic lipase displacement and the hydrolytic activity of hepatic lipase, overview
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+-)-2-hydroxy-4-phenylbutyric acid ethyl ester + H2O
?
show the reaction diagram
-
enantioselectivity of the immobilized enzyme in this reaction is increased 40fold by presence of 0.1% CTAB
-
-
?
(+/-)-trans-3-(4'-methoxy-phenyl)-glycidyl methyl ester + H2O
(2R,3S)-3-(4-hydroxyphenyl)oxirane-2-carboxylic acid + methyl (2S,3R)-3-(4-hydroxyphenyl)oxirane-2-carboxylate + methanol
show the reaction diagram
-
50% conversion yield after 4 h in 100 mM potassium phosphate buffer, pH 7.5, at 30 °C
-
-
?
(3aR,6aS)-2-oxo-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-3-yl acetate + H2O
(3S,3aR,6aS)-2-oxo-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-3-yl acetate + (3R,3aS,6aS)-3-hydroxy-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-2-one + acetate
show the reaction diagram
-
-
-
-
-
(4S)-4-tert-butyl-2-phenyl-1,3-oxazol-5(4H)-one + butanol
butyl (2S)-2-(benzoylamino)3,3-dimethylbutanoate
show the reaction diagram
-
-
-
-
-
(5R,6R)-6-hydroxy-5,6-dihydro-1,10-phenanthrolin-5-yl acetate + vinyl acetate
(5S,6S)-6-hydroxy-5,6-dihydro-1,10-phenanthrolin-5-yl acetate + (5R,6R)-5,6-dihydro-1,10-phenanthroline-5,6-diyl diacetate + ethenol
show the reaction diagram
-
-
-
-
?
(R)-2-ethylhexanoic acid ethyl ester + H2O
(R)-2-ethylhexanoate + ethanol
show the reaction diagram
-
-
-
-
?
(R)-3,5,5-trimethylhexanoic acid ethyl ester + H2O
(R)-3,5,5-trimethylhexanoate + ethanol
show the reaction diagram
-
-
-
-
?
(R,S)-1-phenylethylamine + ethyl methoxyacetate
(S)-1-phenylethylamine + 2-methoxy-N-[(1R)-1-phenylethyl]acetamide + ethanol
show the reaction diagram
-
-
-
-
-
(R,S)-2-O-butyryl-2-phenylacetate + H2O
(R)-2-O-butyryl-2-phenylacetate + (2S)-hydroxy(phenyl)ethanoic acid + butyrate
show the reaction diagram
-
Enantioselectivity of the reaction can be obtained with various methods of enzyme immoblisation and reaction conditions
-
-
?
(R,S)-flurbiprofen ethyl ester + H2O
(S)-flurbiprofen + ethanol
show the reaction diagram
(R,S)-flurbiprofen ethyl ester + H2O
(S)-flurbiprofen ethyl ester + (R)-flurbiprofen + ethanol
show the reaction diagram
(R,S)-ibuprofen + 1-propanol
(S)-ibuprofen n-propyl ester + (R)-ibuprofen
show the reaction diagram
(R,S)-mandelonitrile + vinyl acetate
(S)-cyano(phenyl)methyl acetate + (R)-mandelonitrite
show the reaction diagram
-
transesterification
-
-
?
(R,S)-naproxen 2,2,2-trifluoroethyl thioester
(S)-naproxen + 2,2,2-trifluorothioethanol + (R)-naproxen 2,2,2-trifluoroethyl thioester
show the reaction diagram
-
(R,S)-profen 2,2,2-trifluoroethyl thioester
-
-
?
(R,S)-[4-[4a,6b(E)]]-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-hydroxy-2H-pyran-2-one + isopropenyl acetate
(R)-(+)-[4-[4a,6b(E)]]-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-hydroxy-2H-pyran-2-one + (S)-(-)-[4-[4a,6b(E)]]-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-acetyloxy-2H-pyran-2-one + prop-1-en-2-ol
show the reaction diagram
-
-
-
-
-
(R/S)-ibuprofen methoxyethyl ester + H2O
(R)-ibuprofen methoxyethyl ester + (S)-ibuprofen + 2-methoxyethanol
show the reaction diagram
Candida cyclindraceae
-
-
-
-
-
(RS)-1-phenylethanol + vinyl acetate
(R)-1-phenylethyl acetate + acetaldehyde + (S)-1-phenylethanol
show the reaction diagram
(RS)-1-phenylethanol + vinyl acetate
(S)-1-phenylethyl acetate + acetaldehyde + (R)-1-phenylethanol
show the reaction diagram
-
-
-
-
?
(RS)-1-phenylethyl acetate + H2O
(R)-1-phenylethanol + acetate + (R)-1-phenylethyl acetate
show the reaction diagram
-
enzyme hydrolyzes mainly the R-enantiomer, temperature-dependent, the enantioselectivity decreases with increasing temperature
-
?
(S)-2-ethyl hexanoic acid ethyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
(S)-3,5,5-trimethylhexanoic acid ethyl ester + H2O
(S)-3,5,5-trimethylhexanoate + ethanol
show the reaction diagram
-
-
-
-
?
(S)-glycidol + vinyl n-butyrate
(2R)-oxiran-2-yl-methyl butanoate + ethenol
show the reaction diagram
-
transesterification
-
-
?
(S,R)-acetic acid 2-methyl-4-oxo-3-prop-2-ynyl-cyclopent-2-enyl ester + H2O
(R)-4-hydroxy-3-methyl-2-prop-2-ynyl-cyclopent-2-enone + (S)-acetic acid 2-methyl-4-oxo-3-prop-2-ynyl-cyclopent-2-enyl ester + acetate
show the reaction diagram
-
-
-
-
-
1,2 di-O-lauryl-rac-glycero-3-(glutaric acid 6-methyl) resorufin ester + H2O
?
show the reaction diagram
-
-
-
-
?
1,2,3-trihexaicosanoylglycerol + H2O
1,2-dihexaicosanoylglycerol + hexaicosanoate
show the reaction diagram
-
-
-
-
?
1,2,3-trioleoyl-glycerol + H2O
?
show the reaction diagram
-
-
-
?
1,2-di-O-lauryl-rac-glycero-3-glutaric acid 6'-methylresorufin ester + H2O
?
show the reaction diagram
chromogenic substrate
-
-
?
1,2-didecanoyl-1-thioglycerol + H2O
?
show the reaction diagram
-
-
-
?
1,2-didecanoyl-rac-glycerol + H2O
?
show the reaction diagram
1,2-dilauryl-rac-glycero-3-glutaric acid resorufinester + H2O
?
show the reaction diagram
1,2-dilinoleoyl-3-oleoyl-rac-glycerol + H2O
?
show the reaction diagram
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
1,2-dioctanoyl-sn-glycero-3-phosphoglycol + H2O
?
show the reaction diagram
-
-
-
?
1,2-dioleoylglycerol + H2O
oleic acid + ?
show the reaction diagram
1,2-dipalmitin + H2O
?
show the reaction diagram
-
-
-
-
?
1,2-O-dilauryl-rac-glycero-3-glutaric acid resorufin ester + H2O
?
show the reaction diagram
-
-
-
?
1,2-O-dilauryl-rac-glycero-3-glutaric resorufin ester + H2O
?
show the reaction diagram
-
commercial chromogenic lipase substrate
-
-
?
1,2-sn-dicaprin + H2O
?
show the reaction diagram
-
regio- and stereoselective reaction
-
-
?
1,3-diolein + H2O
1-oleoyl-sn-glycerol + oleate
show the reaction diagram
low activity
-
-
?
1,3-dioleoyl-2-palmitoyl-glycerol + H2O
?
show the reaction diagram
-
not BTID-A
-
?
1,3-dipalmitoyl-2-oleoyl-glycerol + H2O
?
show the reaction diagram
-
-
-
?
1-caprin + H2O
glycerol + caprate
show the reaction diagram
-
-
-
-
?
1-monopalmitin + H2O
palmitic acid + glycerol
show the reaction diagram
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
show the reaction diagram
1-naphthyl butyrate + H2O
1-naphthol + butyrate
show the reaction diagram
-
18.8% activity compared to rice bran oil
-
-
?
1-naphthyl octanoate + H2O
1-naphthol + octanoate
show the reaction diagram
-
-
-
-
?
1-olein + H2O
glycerol + oleate
show the reaction diagram
-
-
-
-
?
1-phenylethanol + vinyl butanoate
?
show the reaction diagram
-
-
-
-
?
1-phenylethanol + vinyl caproate
?
show the reaction diagram
-
-
-
-
?
1-phenylethanol + vinyl octanoate
?
show the reaction diagram
-
-
-
-
?
1-stearoyl-2-arachidonoyl-sn-glycerol + H2O
?
show the reaction diagram
-
-
-
?
2 triolein + H2O
3 oleic acid + 2-monoolein + 1,3-diolein
show the reaction diagram
-
1,3-specificity for triolein
-
-
?
2,3-dibutyrylthio-1-propyl oleate + H2O
2,3-dibutyrylthiopropyl alcohol + oleate
show the reaction diagram
-
chromogenic detection using 5,5'-dithio-bis-(2-nitrobenzoic acid) as chromogen or the 6-methylresorufin ester of 1-O,2-dilauryl-rac-glycero-3-glutaric acid, substrate synthesis, assay development, optimization, and method comparison, overview
-
-
?
2,3-dimercapto-1-propanol tributyrate + H2O
?
show the reaction diagram