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Literature summary for 3.1.1.3 extracted from
- Triacylglycerol hydrolase: role in intracellular lipid metabolism (2004), Cell. Mol. Life Sci., 61, 1633-1651.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | phosphorylation at Ser506 activates the enzyme by 100-140% | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DNA and amino acid sequence determination and analysis, the genes encoding the enzyme are located on chromosome 8 within a cluster of carboxylesterase genes, genetic organization, expression analysis | Mus musculus |
| the genes encoding the enzyme are located on chromosome 16 within a cluster of carboxylesterase genes, genetic organization, expression analysis | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | a perilipin-regulation mutant shows increased enzyme activity in adipose tissue and increased lipolysis leading to lean mice | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Mus musculus | 5783 | - |
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
| endoplasmic reticulum | - |
Sus scrofa | 5783 | - |
| endoplasmic reticulum | - |
Bos taurus | 5783 | - |
| lipid droplet | - |
Mus musculus | 5811 | - |
| lipid droplet | - |
Homo sapiens | 5811 | - |
| lipid droplet | - |
Rattus norvegicus | 5811 | - |
| lipid droplet | - |
Sus scrofa | 5811 | - |
| lipid droplet | - |
Bos taurus | 5811 | - |
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Sus scrofa | - |
- |
| microsome | - |
Bos taurus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? |  |
| additional information | Rattus norvegicus | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? | |
| additional information | Sus scrofa | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? | |
| additional information | Bos taurus | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? | |
| additional information | Mus musculus | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, the hormone-sensitive lipase is negatively regulated by perilipin in adipose tissue, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | posttranslational regulation by N-glycosylation at Asn79 | Homo sapiens |
| glycoprotein | posttranslational regulation by N-glycosylation at Asn79 and Asn489 | Mus musculus |
| phosphoprotein | a phosphorylation site is Ser506, phosphorylation activates the enzyme | Rattus norvegicus |
| phosphoprotein | phosphorylation sites are Tyr218 and at seven Ser/Thr consensus sequences | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| from liver microsomes | Mus musculus |
| from liver microsomes | Homo sapiens |
| from liver microsomes | Sus scrofa |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| triacylglycerol + H2O = diacylglycerol + a carboxylate | activation mechanism | Rattus norvegicus | |
| triacylglycerol + H2O = diacylglycerol + a carboxylate | active site structure, reaction mechanism | Mus musculus | |
| triacylglycerol + H2O = diacylglycerol + a carboxylate | active site structure, reaction mechanism | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipocyte | hormone-sensitive lipase is negatively regulated by perilipin, lipolysis of storage triacylglycerides | Mus musculus | - |
| adipocyte | hormone-sensitive lipase, lipolysis of storage triacylglycerides | Homo sapiens | - |
| adipocyte | hormone-sensitive lipase, lipolysis of storage triacylglycerides | Rattus norvegicus | - |
| adipocyte | hormone-sensitive lipase, lipolysis of storage triacylglycerides | Sus scrofa | - |
| adipocyte | hormone-sensitive lipase, lipolysis of storage triacylglycerides | Bos taurus | - |
| heart | - |
Mus musculus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Sus scrofa | - |
| liver | - |
Bos taurus | - |
| liver | regulation of enzyme expression, transcription factor binding, overview | Mus musculus | - |
| macrophage | - |
Homo sapiens | - |
| additional information | no expression in brain, skeletal muscle, or spleen, tissue-specific functions, expression is developmentally regulated, detailed overview | Mus musculus | - |
| additional information | tissue-specific functions, expression is developmentally regulated, detailed overview | Homo sapiens | - |
| additional information | tissue-specific functions, expression is developmentally regulated, detailed overview | Rattus norvegicus | - |
| additional information | tissue-specific functions, expression is developmentally regulated, detailed overview | Sus scrofa | - |
| additional information | tissue-specific functions, expression is developmentally regulated, detailed overview | Bos taurus | - |
| small intestine | - |
Mus musculus | - |
| small intestine | - |
Homo sapiens | - |
| small intestine | - |
Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Rattus norvegicus | ? | - |
? | |
| additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Sus scrofa | ? | - |
? | |
| additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Bos taurus | ? | - |
? | |
| additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, the hormone-sensitive lipase is negatively regulated by perilipin in adipose tissue, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | secondary and three-dimensional structure analysis, overview | Mus musculus |
| More | secondary and three-dimensional structure analysis, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hormone-sensitive lipase | - |
Mus musculus |
| hormone-sensitive lipase | - |
Homo sapiens |
| hormone-sensitive lipase | - |
Rattus norvegicus |
| hormone-sensitive lipase | - |
Sus scrofa |
| hormone-sensitive lipase | - |
Bos taurus |
| HSL | - |
Mus musculus |
| HSL | - |
Homo sapiens |
| HSL | - |
Rattus norvegicus |
| HSL | - |
Sus scrofa |
| HSL | - |
Bos taurus |
| TGH | - |
Mus musculus |
| TGH | - |
Homo sapiens |
| TGH | - |
Rattus norvegicus |
| TGH | - |
Sus scrofa |
| TGH | - |
Bos taurus |
| triacylglycerol hydrolase | - |
Mus musculus |
| triacylglycerol hydrolase | - |
Homo sapiens |
| triacylglycerol hydrolase | - |
Rattus norvegicus |
| triacylglycerol hydrolase | - |
Sus scrofa |
| triacylglycerol hydrolase | - |
Bos taurus |
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Release 2023.1 (January 2023)
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