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Literature summary for 3.1.1.3 extracted from

  • MacKeith R.A.; McCague R.; Olivo H.F.; Roberts S.M.; Taylor S.J.; Xiong H.
    Enzyme-catalysed kinetic resolution of 4-endo-hydroxy-2-oxabicyclo[3.3.0]oct-7-en-3-one and employment of the pure enantiomers for the synthesis of anti-viral and hypocholesteremic agents (1994), Bioorg. Med. Chem., 2, 387-394.
    View publication on PubMed

Application

Application Comment Organism
synthesis production of (-)-4-endo-hydroxy-2-oxabicyclo[3.3.0]oct-7-en-3-one, which is an intermediate for the anti-HIV agent carbovir Pseudomonas fluorescens

Organism

Organism UniProt Comment Textmining
Pseudomonas fluorescens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3aR,6aS)-2-oxo-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-3-yl acetate + H2O
-
Pseudomonas fluorescens (3S,3aR,6aS)-2-oxo-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-3-yl acetate + (3R,3aS,6aS)-3-hydroxy-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-2-one + acetate
-
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Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
-
Pseudomonas fluorescens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Pseudomonas fluorescens