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Literature summary for 3.1.1.3 extracted from

  • Kratky, D.; Obrowsky, S.; Kolb, D.; Radovic, B.
    Pleiotropic regulation of mitochondrial function by adipose triglyceride lipase-mediated lipolysis (2014), Biochimie, 96, 106-112.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.3

Activating Compound

Activating Compound Comment Organism Structure
CGI-58 for maximal lipolytic activity the enzyme requires CGI-58 as a co-activator Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
triacylglycerol + H2O Mus musculus
-
 diacylglycerol + a carboxylate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Mus musculus
-
brain
-
 Mus musculus
-
brown adipose tissue
-
 Mus musculus
-
cardiac muscle
-
 Mus musculus
-
INS-1 823/13 cell
-
 Mus musculus
-
liver
-
 Mus musculus
-
macrophage
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-
small intestine
-
 Mus musculus
-
white adipose tissue
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme lacks the ability to hydrolyze diacylglycerols, monoacylglycerols, cholesteryl esters, or retinyl esters Mus musculus ?
-
 ?
triacylglycerol + H2O
-
 Mus musculus diacylglycerol + a carboxylate
-
 ?

Synonyms

Synonyms Comment Organism
adipose triglyceride lipase
-
 Mus musculus
ATGL
-
 Mus musculus

General Information

General Information Comment Organism
malfunction the absence of adipose triglyceride lipase has pleiotropic roles in mitochondrial function Mus musculus