Information on EC 4.2.1.1 - carbonate dehydratase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
4.2.1.1
-
RECOMMENDED NAME
GeneOntology No.
carbonate dehydratase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
H2CO3 = CO2 + H2O
show the reaction diagram
-
-
-
-
H2CO3 = CO2 + H2O
show the reaction diagram
carbonic anhydrase III is limited in rate by a step occuring outside the actual interconversion of CO2 and HCO3- and involving a change in bonding to hydrogen exchangeable with solvent water
-
H2CO3 = CO2 + H2O
show the reaction diagram
zinc-hydroxide mechanism, rate-determining H+ transfer step in catalytic mechanism
-
H2CO3 = CO2 + H2O
show the reaction diagram
mechanism
-
H2CO3 = CO2 + H2O
show the reaction diagram
the rate limiting step in catalysis of bicarbonate dehydration by HCA II is an intramolecular proton transfer from His64 to the zinc-bound hydroxide
-
H2CO3 = CO2 + H2O
show the reaction diagram
reaction mechanism, overview
-, P45148
H2CO3 = CO2 + H2O
show the reaction diagram
reaction mechanism, model of the active site designed on the basis of the X-ray crystal structure, proposed for both metal ions similar reaction pathways consisting in the nucleophilic attack by the metal bound hydroxide to the carbon dioxide with bicarbonate formation, in a next internal rotation of this last fragment, and then in the formation of a species ready for the product removal, overview
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
addition
-
-
-
-
dehydration
-
-
dehydration
-
-
dehydration
-
-
dehydration
P16016
-
dehydration
-
-
dehydration
-
-
dehydration
-
-
dehydration
Q8W183
-
dehydration
-
-
dehydration
P61517
-
dehydration
Helicobacter pylori 26695 (HP1186), Rattus norvegicus Sprague-Dawley
-
-
-
elimination
-
-
-
-
hydration
-
of CO2
hydration
-
-
hydration
-
-
hydration
P16016
-
hydration
-
-
hydration
Q8W183
-
hydration
P61517
-
hydration
Helicobacter pylori 26695 (HP1186), Rattus norvegicus Sprague-Dawley
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
CO2 fixation into oxaloacetate (anapleurotic)
-
cyanate degradation
-
gluconeogenesis II (Methanobacterium thermoautotrophicum)
-
Nitrogen metabolism
-
SYSTEMATIC NAME
IUBMB Comments
carbonate hydro-lyase (carbon-dioxide-forming)
A zinc protein.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
(CA) XIV
-
-
AaCA1
-
-
alpha class carbonic anhydrase
-
-
alpha-CA
-
-
alpha-carbonic anhydrase
-
-
alpha-carbonic anhydrase
-
-
alpha-carbonic anhydrase
Helicobacter pylori 26695 (HP1186)
-
-
-
alpha-carbonic anhydrase
-
-
alpha-carbonic anhydrase
-
-
alpha-carbonic anhydrase
-
-
alpha-class carbonic anhydrase
-
-
alpha-type carbonic anhydrase
-
-
alpha-type carbonic anhydrase
P54212
-
alpha-type carbonic anhydrase
A7DX12, A7DX13
-
alpha-type carbonic anhydrase
Lotus japonicus Gifu B-129
A7DX12, A7DX13
-
-
alpha-type carbonic anhydrase
Q8KJM6
-
alpha-type carbonic anhydrase
Q8KJM6
-
-
anhydrase
-
-
-
-
bCA IV
-
-
BCAII
-
-
BCAIIGln253Cys
-
-
beta-CA
-
-
beta-CA
-
-
beta-carbonic anhydrase
-
-
beta-carbonic anhydrase
Q8FVP0
-
beta-carbonic anhydrase
Q8FVP0
-
-
beta-carbonic anhydrase
-
-
beta-carbonic anhydrase
-
-
beta-carbonic anhydrase
-
-
beta-carbonic anhydrase
Chlamydomonas reinhardtii D66
-
-
-
beta-carbonic anhydrase
-
-
beta-carbonic anhydrase
-
-
beta-carbonic anhydrase
-
-
beta-carbonic anhydrase
P61517
-
beta-carbonic anhydrase
P46510, Q84Y09, Q84Y10
-
beta-carbonic anhydrase
Flaveria bidentis Kuntze
P46510, Q84Y09, Q84Y10
-
-
beta-carbonic anhydrase
-
-
beta-carbonic anhydrase
P45148
-
beta-carbonic anhydrase
-
-
beta-carbonic anhydrase
-
-
beta-carbonic anhydrase
-
-
beta-carbonic anhydrase
-
-
beta-carbonic anhydrase
-
-
beta-carbonic anhydrase
-
-
beta-class carbonic anhydrase
-
-
beta-class carbonic anhydrase
Azospirillum brasilense Sp7
-
-
-
beta-class carbonic anhydrase
-
-
beta-class carbonic anhydrase
Q50565
-
beta-class carbonic anhydrase
P16016
-
bovine carbonic anhydrase II
-
-
bsCA I
Q8FVP0
-
bsCA I
Q8FVP0
-
-
bsCA II
Q8FVP0
-
bsCA II
Q8FVP0
-
-
CA
-
-
-
-
CA 1
Q8FVP0
-
CA I
-
cytosolic isoform
CA I
Q16790
isozyme
CA II
-
cytosolic isoform
CA II
P00918
isoform
CA II
Q16790
isozyme
CA III
-
-
CA III
-
isoform
CA III
-
isozyme
CA IV
-
isozyme
CA IV
-
-
CA IV
Mus musculus C57BL/6J
-
-
-
CA IX
Q16790
isozyme
CA VA
-
isozyme
CA VA
-
mitochondrial isoform
CA VA
P35218
isoform
CA VB
-
isozyme
CA VB
-
mitochondrial isoform
CA VB
Q9Y2D0
isoform
CA VI
-
-
CA VI
-
isozyme
CA VI
Rattus norvegicus Sprague-Dawley
-
-
-
CA VII
-
isozyme
CA VIII
P35219
-
CA XII
-
-
CA XII
-
isozyme
CA XII
O43570
-
CA XIII
-
isoform
CA XIII
-
isozyme
CA XIII
-
-
CA XIII
-
isoform
CA XIII
Q8N1Q1
-
CA XIV
-
isozyme
CA XIV
Q9ULX7
-
Ca XV
-
isozyme
CA-I
P83299
-
CA-I
-
isozyme
CA-II
-
-
CA-II
Gallus gallus Araucana-chicken
-
-
-
CA-II
-
-
CA-II
-
isozyme
CA-III
P07451
-
CA-IX
-
-
-
-
CA-VA
-
-
-
-
CA-VB
-
-
-
-
CA-VI
-
-
-
-
CA-VI
P23280
-
CA-VII
-
-
-
-
CA-XII
-
-
-
-
CA-XIV
-
-
-
-
CA1
-
-
-
-
CA1
P46510
-
CA1
Flaveria bidentis Kuntze
P46510
-
-
CA14x
-
-
CA2
-
-
-
-
CA2
Q84Y10
-
CA2
Flaveria bidentis Kuntze
Q84Y10
-
-
CA3
Q84Y09
-
CA3
Flaveria bidentis Kuntze
Q84Y09
-
-
CAA1
A7DX12
-
CAA1
Lotus japonicus Gifu B-129
A7DX12
-
-
CAA1
Q8KJM6
-
CAA1
Q8KJM6
-
-
CAA2
A7DX13
-
CAA2
Lotus japonicus Gifu B-129
A7DX13
-
-
cab-type beta-class carbonic anhydrase
-
-
cadmium carbonic anhydrase
-
-
CAH7
Chlamydomonas reinhardtii D66
-
isoform
-
CAH8
Chlamydomonas reinhardtii D66
-
isoform
-
CAII
-
-
CAII
P00918
-
CAIII
-
-
CAIII
-
-
CAIII
P14141
-
CAIV
-
-
CAIX
-
-
-
-
CAIX
-
isoform
CaNce103
-
-
carbonate anhydrase
-
-
-
-
Carbonate dehydratase
-
-
-
-
carbonate dehydratase I
P83299
-
carbonate dehydratase III
P07451
-
Carbonate dehydratase IX
-
-
-
-
Carbonate dehydratase VA
-
-
-
-
Carbonate dehydratase VB
-
-
-
-
Carbonate dehydratase VI
-
-
-
-
Carbonate dehydratase VI
P23280
-
Carbonate dehydratase VII
-
-
-
-
Carbonate dehydratase XII
-
-
-
-
Carbonate dehydratase XIV
-
-
-
-
carbonate hydro-lyase
-
-
carbonate hydro-lyase
Bacillus subtilis SA3
-
-
-
carbonate hydrolase
-
-
carbonate hydrolase
P61517
-
carbonate hydrolyase
-
-
carbonate hydrolyase
-
-
carbonic acid anhydrase
-
-
-
-
carbonic anhydrase
-
-
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
Bacillus subtilis SA3
-
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
Haematococcus pluvialis CG-11
-
-
-
carbonic anhydrase
P00918
-
carbonic anhydrase
P35218
-
carbonic anhydrase
Q16790
-
carbonic anhydrase
Q9Y2D0
-
carbonic anhydrase
-
-
carbonic anhydrase
P40881
-
carbonic anhydrase
-
-
carbonic anhydrase
Micrococcus luteus 2
-
;
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
Pyrococcus horikoshii OT-3
-
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
P53615
-
carbonic anhydrase
-
-
carbonic anhydrase
B5SU02
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase
-
-
carbonic anhydrase 1
P46510
-
carbonic anhydrase 1
Flaveria bidentis Kuntze
P46510
-
-
carbonic anhydrase 1
-
-
carbonic anhydrase 14
Q9ULX7
-
carbonic anhydrase 2
Q84Y10
-
carbonic anhydrase 2
Flaveria bidentis Kuntze
Q84Y10
-
-
carbonic anhydrase 2
Q7T2K6
-
carbonic anhydrase 3
Q84Y09
-
carbonic anhydrase 3
Flaveria bidentis Kuntze
Q84Y09
-
-
carbonic anhydrase 3
P07451
-
carbonic anhydrase cambialistic enzyme
-
-
carbonic anhydrase I
P83299
-
carbonic anhydrase I
-
isoform
carbonic anhydrase I
-
isozyme
carbonic anhydrase I (CA I) Michigan 1
-
-
carbonic anhydrase II
-
-
carbonic anhydrase II
-
-
carbonic anhydrase II
-
-
carbonic anhydrase II
Gallus gallus Araucana-chicken
-
-
-
carbonic anhydrase II
-
isoform
carbonic anhydrase II
-
isozyme
carbonic anhydrase II
P00918
-
carbonic anhydrase III
-
-
carbonic anhydrase III
-
-
carbonic anhydrase III
-
isozyme
carbonic anhydrase III
-
the enzyme possesses only low carbon dioxide hydratase activity
carbonic anhydrase III
P07451
-
carbonic anhydrase III
P14141
-
carbonic anhydrase isozyme I
-
-
carbonic anhydrase isozyme II
-
-
carbonic anhydrase isozyme III
-
-
carbonic anhydrase isozyme IV
-
-
carbonic anhydrase isozyme IX
-
-
carbonic anhydrase IV
-
-
carbonic anhydrase IV
-
-
carbonic anhydrase IV
-
isozyme
carbonic anhydrase IV
-
-
carbonic anhydrase IV
Mus musculus C57BL/6J
-
-
-
carbonic anhydrase IX
Q16790
-
carbonic anhydrase type III
-
-
carbonic anhydrase V
-
-
carbonic anhydrase V
-
-
carbonic anhydrase VI
-
-
carbonic anhydrase VI
P23280
-
carbonic anhydrase VI
-
-
carbonic anhydrase VI
Rattus norvegicus Sprague-Dawley
-
-
-
carbonic anhydrase VII
-
-
carbonic anhydrase XII
-
-
carbonic anhydrase XII
O43570
-
carbonic anhydrase XIII
-
-
carbonic anhydrase XIII
-
isoform
carbonic anhydrase XIII
Q8N1Q1
-
carbonic anhydrase XIV
Q9ULX7
-
carbonic anhydrase XIV
-
-
carbonic anhydrase XV
-
-
carbonic anhydrase XV
-
isoform
carbonic anhydrase-I
-
isozyme
carbonic anhydrase-I
P00915
-
carbonic anhydrase-II
-
isozyme
carbonic anhydrase-related protein
-
-
carbonic anhydrase-related protein VIII
P35219
-
carbonic dehydratase
-
-
-
-
carboxyanhydrase
-
-
-
-
CARP
-
-
CasCAc
A3FFY1
-
CasCAg
A3FFY2
-
CAXII
-
isoform
chloroplast carbonic anhydrase
-
-
CO2 hydratase
-
-
CynT2
P61517
-
cytoplasmic carbonic anhydrase
Q6R4A2
-
Dca
P54212
-
dehydratase, carbonate
-
-
-
-
diatom carbonic anhydrase
-
-
erythrocyte carbonic anhydrase
Q7T2K6
-
external carbonic anhydrase
-
-
gamma-carbonic anhydrase
-
-
gamma-carbonic anhydrase
-
-
gamma-class carbonic anhydrase
-
-
gamma-class carbonic anhydrase
P40881
-
H216N ATCA
-
-
H64A HCA II
-
-
HC II
-
-
hCA IV
-
-
hCA XII
-
-
hCA XII
O14939
-
hCA XII
O43570
-
hCA XIV
Q9ULX7
-
hCA XIV catalytic domain
Q9ULX7
-
HCA-I
-
-
hCAII
-
-
hCAII
P00918
-
hpalphaCA
Q9WVT6
-
hpbetaCA
Q1CVF1
-
human carbonic anhydrase
-
-
human carbonic anhydrase I
-
-
human carbonic anhydrase III
-
-
human carbonic anhydrase isoenzyme I
-
-
human carbonic anhydrase isoenzyme II
-
-
human carbonic anhydrase IX
-
-
human carbonic anhydrase XII
-
-
Ice-CA
P83299
-
isozyme CA II
-
-
isozyme CA IV
-
-
mCA V
-
-
mCA XIII
-
-
mCA XIII
Q8N1Q1
-
mCA XIII
Q9D6N1
-
OEC33 protein
-
-
P54/58N
-
-
-
-
plant-type (beta-class) carbonic anhydrase
-
-
pMW1
-
-
-
-
RCC-associated antigen G250
-
-
-
-
Renal cell carcinoma-associated antigen G250
-
-
-
-
RT erythrocyte CA
-
-
Salivary carbonic anhydrase
-
-
-
-
Salivary carbonic anhydrase
P23280
-
Secreted carbonic anhydrase
-
-
-
-
Secreted carbonic anhydrase
P23280
-
secretory carbonic anhydrase
-
-
TCAb
Q7T2K6
-
TCAc
Q6R4A2
-
tobacco salicylic acid-binding protein 3
-
-
Tumor antigen HOM-RCC-3.1.3
-
-
-
-
Membrane antigen MN
-
-
-
-
additional information
P45148
HICA is a type II member of the beta-carbonic anhydrase family
additional information
-
the enzyme from Methanosorcina thermophila belongs to the gamma class carbonic anhydrases
CAS REGISTRY NUMBER
COMMENTARY
9001-03-0
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
european moose
-
-
Manually annotated by BRENDA team
Caro, varity: Gaoyou
-
-
Manually annotated by BRENDA team
red-blooded teleost
-
-
Manually annotated by BRENDA team
ecotype Columbia-0
-
-
Manually annotated by BRENDA team
Azospirillum brasilense Sp7
strain Sp7
-
-
Manually annotated by BRENDA team
strain SA3
-
-
Manually annotated by BRENDA team
Bacillus subtilis SA3
strain SA3
-
-
Manually annotated by BRENDA team
carbonic anhydrase III
-
-
Manually annotated by BRENDA team
commentary
-
-
Manually annotated by BRENDA team
strain 1330; two beta class isozymes bsCA I and bsCA II, gene BR1829
UniProt
Manually annotated by BRENDA team
strain 1330; two beta class isozymes bsCA I and bsCA II, gene BR1829
UniProt
Manually annotated by BRENDA team
six genes, cah-1, cah-2, cah-3, cah-4, cah-5, and cah-6, possibly encoding alpha class carbonic anhydrases
-
-
Manually annotated by BRENDA team
Mongrel dog
-
-
Manually annotated by BRENDA team
Chaetoceros vixvisibilis
-
-
-
Manually annotated by BRENDA team
icefish, haemoglobinloss teleost
-
-
Manually annotated by BRENDA team
carbonic anhydrase 1 and 2
-
-
Manually annotated by BRENDA team
isozyme alphaCA1
-
-
Manually annotated by BRENDA team
Chlamydomonas reinhardtii D66
strain D66
-
-
Manually annotated by BRENDA team
Coccomyxa sp.
-
-
-
Manually annotated by BRENDA team
Elephas trogontherii
-
-
-
Manually annotated by BRENDA team
carbonic anhydrase III
-
-
Manually annotated by BRENDA team
strain Kuntze
SwissProt
Manually annotated by BRENDA team
Flaveria bidentis Kuntze
strain Kuntze
SwissProt
Manually annotated by BRENDA team
i.e. WL-chicken, male and female chicken, isozyme CA-II; male and female chicken, isozyme CA-II
-
-
Manually annotated by BRENDA team
Gallus gallus Araucana-chicken
i.e. WL-chicken, male and female chicken, isozyme CA-II; male and female chicken, isozyme CA-II
-
-
Manually annotated by BRENDA team
Haematococcus pluvialis CG-11
-
-
-
Manually annotated by BRENDA team
strain 26695 (HP1186) and ATCC type strain 628572
-
-
Manually annotated by BRENDA team
Helicobacter pylori 26695 (HP1186)
strain 26695 (HP1186) and ATCC type strain 628572
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
American Negroes
-
-
Manually annotated by BRENDA team
carbonic anhydrase 14 precursor; recombinant
SwissProt
Manually annotated by BRENDA team
carbonic anhydrase I, II and III; carbonic anhydrase IV
-
-
Manually annotated by BRENDA team
carbonic anhydrase II
-
-
Manually annotated by BRENDA team
carbonic anhydrase II; carbonic anhydrase IV
-
-
Manually annotated by BRENDA team
carbonic anhydrase III
-
-
Manually annotated by BRENDA team
carbonic anhydrase IV
-
-
Manually annotated by BRENDA team
human
-
-
Manually annotated by BRENDA team
isozyme CA IX
SwissProt
Manually annotated by BRENDA team
isozyme CAIX
-
-
Manually annotated by BRENDA team
isozymes carbonic anhydrase I and II
-
-
Manually annotated by BRENDA team
isozymes hCA I, hCA II, hCA IX, and hCA XII
-
-
Manually annotated by BRENDA team
isozymes hCA I, II, III, VII and XIII
-
-
Manually annotated by BRENDA team
isozymes I, II, IX and XII
-
-
Manually annotated by BRENDA team
isozymes, hCA I, hCA II, hCA IX, and hCA XII
-
-
Manually annotated by BRENDA team
no expression of carbonic anhydrase XV
SwissProt
Manually annotated by BRENDA team
recombinant
SwissProt
Manually annotated by BRENDA team
recombinant
SwissProt
Manually annotated by BRENDA team
recombinant
-
-
Manually annotated by BRENDA team
wild-type carbonic anhydrase I and active-site mutants V62N, H67N, H200T, double-mutant V62N,H67N, and triple-mutant V62H,H67N,H200T. Wild-type carbonic anhydrase II and active site mutant enzymes N62V, N67H and T200H
-
-
Manually annotated by BRENDA team
a high-MW enzyme form and a low-MW enzyme form
-
-
Manually annotated by BRENDA team
adult female Weddell seals
-
-
Manually annotated by BRENDA team
formerly Gonyaulax polyedra
-
-
Manually annotated by BRENDA team
isozyme LjCAA1; isozymes LjCAA1 and LjCAA2
UniProt
Manually annotated by BRENDA team
isozyme LjCAA2; isozymes LjCAA1 and LjCAA2
UniProt
Manually annotated by BRENDA team
Lotus japonicus Gifu B-129
isozyme LjCAA1; isozymes LjCAA1 and LjCAA2
UniProt
Manually annotated by BRENDA team
Lotus japonicus Gifu B-129
isozyme LjCAA2; isozymes LjCAA1 and LjCAA2
UniProt
Manually annotated by BRENDA team
Lupinus sp.
-
-
-
Manually annotated by BRENDA team
Macropus eugenii desmarest
tammar wallaby
-
-
Manually annotated by BRENDA team
two distinct kinds of isoenzymes: high activity carbonic anhydrase and low activity carbonic anhydrase
-
-
Manually annotated by BRENDA team
Melilotus sp.
-
-
-
Manually annotated by BRENDA team
strain R7A
UniProt
Manually annotated by BRENDA team
strain R7A
UniProt
Manually annotated by BRENDA team
carbonic anhydrase precursor
SwissProt
Manually annotated by BRENDA team
Micrococcus luteus 2
-
-
-
Manually annotated by BRENDA team
Balb/c lung carbonic anhydrase IV
-
-
Manually annotated by BRENDA team
carbonic anhydrase V
-
-
Manually annotated by BRENDA team
carbonic anhydrase VII
-
-
Manually annotated by BRENDA team
carbonic anhydrase XIV
Uniprot
Manually annotated by BRENDA team
Mus musculus C57BL/6J
-
-
-
Manually annotated by BRENDA team
strain 6021
-
-
Manually annotated by BRENDA team
Neisseria sicca 6021
strain 6021
-
-
Manually annotated by BRENDA team
no activity in Homo sapiens
carbonic anhydrase XV is not expressed in humans, non-processed pseudogene
-
-
Manually annotated by BRENDA team
rainbow trout
-
-
Manually annotated by BRENDA team
high-MW carbonic anhydrase
-
-
Manually annotated by BRENDA team
Merino sheep
-
-
Manually annotated by BRENDA team
ovis aries
-
-
Manually annotated by BRENDA team
no expression of carbonic anhydrase XV
-
-
Manually annotated by BRENDA team
black tiger shrimp
-
-
Manually annotated by BRENDA team
strain UTEX642
Uniprot
Manually annotated by BRENDA team
Phaeodactylum tricornutum UTEX642
strain UTEX642
Uniprot
Manually annotated by BRENDA team
cultivar Ran 1
-
-
Manually annotated by BRENDA team
tremuloides
-
-
Manually annotated by BRENDA team
strain OT3
-
-
Manually annotated by BRENDA team
Pyrococcus horikoshii OT-3
strain OT3
-
-
Manually annotated by BRENDA team
carbonic anhydrase III
-
-
Manually annotated by BRENDA team
carbonic anhydrase IV
-
-
Manually annotated by BRENDA team
Sprague Dawley
-
-
Manually annotated by BRENDA team
Sprague-Dawley
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
Sprague-Dawley
-
-
Manually annotated by BRENDA team
strain S288c
UniProt
Manually annotated by BRENDA team
spinach
SwissProt
Manually annotated by BRENDA team
isozymes STPCA and STPCA-2
-
-
Manually annotated by BRENDA team
red-blooded teleost
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
evolution
-, P45148
HICA is a type II member of the beta-carbonic anhydrase family
evolution
Q8FVP0
evolutionary tree of some bacterial beta-CAs among which the two Brucella suis isozymes bsCA I and bsCA II, phylogenetic analysis, overview
evolution
-
phylogenetic analysis of beta-class carbonic anhydrases in invertebrates, overview
evolution
-
carbonic anhydrase represents one of the most ancient proteins
evolution
-
evolutionary tree of some bacterial beta-CAs among which the two Brucella suis isozymes bsCA I and bsCA II, phylogenetic analysis, overview
-
malfunction
-
isozyme CAIX expression and activity is associated with metabolic dysfunction in MDA-MB-231 cells
malfunction
-
CA IV-/- mice show a 32.13% reduction in total carbonic anhydrase activity and reduced beat frequency compared to the wild-type
physiological function
-
isoform CA IX is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control
physiological function
-
beta carbonic anhydrase is required for scavenging CO2 from the ambient air
physiological function
-
CA IX is involved in solid tumor acidification
physiological function
-
the enzyme from chicken has an important role in eggshell formation
physiological function
-
CAIX is a zinc metalloenzyme that catalyzes the reversible hydration of CO2. CAIX expression is strongly induced by hypoxia and is significantly associated with tumor grade and poor survival
physiological function
A7DX12, A7DX13, -
isozyme LjCAA1 is involved in nitrogen ficxation/assimilation, but may also be involved in biochemical and physiological processes not directly linked to nitrogen fixation/assimilation; isozyme LjCAA2 is involved in nitrogen fixation/assimilation, but may also be involved in biochemical and physiological processes not directly linked to nitrogen fixation/assimilation
physiological function
-
isoyzme CAII is associated with the acute mountain sickness, a common disease at high altitude
physiological function
-
role of isozyme carbonic anhydrase IV in the bicarbonate-mediated activation of sperm, overview. Sperm respond to CO2 with an increase in beat frequency, an effect that can be inhibited by ethoxyzolamide. CA IV supplies sperm with HCO3-, which is necessary for stimulation of atypical sperm adenylyl cyclase and hence early activation of spermatozoa
physiological function
Azospirillum brasilense Sp7
-
beta carbonic anhydrase is required for scavenging CO2 from the ambient air
-
physiological function
Gallus gallus Araucana-chicken
-
the enzyme from chicken has an important role in eggshell formation
-
physiological function
Lotus japonicus Gifu B-129
-
isozyme LjCAA1 is involved in nitrogen ficxation/assimilation, but may also be involved in biochemical and physiological processes not directly linked to nitrogen fixation/assimilation; isozyme LjCAA2 is involved in nitrogen fixation/assimilation, but may also be involved in biochemical and physiological processes not directly linked to nitrogen fixation/assimilation
-
physiological function
Mus musculus C57BL/6J
-
role of isozyme carbonic anhydrase IV in the bicarbonate-mediated activation of sperm, overview. Sperm respond to CO2 with an increase in beat frequency, an effect that can be inhibited by ethoxyzolamide. CA IV supplies sperm with HCO3-, which is necessary for stimulation of atypical sperm adenylyl cyclase and hence early activation of spermatozoa
-
malfunction
Mus musculus C57BL/6J
-
CA IV-/- mice show a 32.13% reduction in total carbonic anhydrase activity and reduced beat frequency compared to the wild-type
-
additional information
-
EGF induces CAIX translocation to lipid rafts but not its phosphorylation
additional information
-
the wide use of dithiocarbamate pesticides may be one of the factors enhancing the vulnerability of this sturgeon species to pollutants, since they act as effective carbonate dehydratase inhibitors
additional information
-
evaluation of efficiency of enzymes from Pseudomonas fragi, Micrococcus lylae, and Micrococcus luteus 2 compared to commercial Bos taurus carbonic anhydrase as biocatalysts in biomimetic sequestration of CO2 into CaCO3, the compared parameters are stability, inhibition rates by toxic metals, and pH dependency, overview. Indigenous carbonic anhydrases and their consortia exhibit enhanced CO2 sequestration competence compared to commercial bovine carbonic anhydrase
additional information
-
Pseudomonas fragi, Micrococcus lylae and Micrococcus luteus 2 along with a comparative evaluation of their efficiency compared to commercial Bis taurus carbonic anhydrase as biocatalysts in biomimetic sequestration of CO2 into CaCO3, aparameters are stability, inhibition rates by toxic metals, and pH dependency, overview. Indigenous CAs and their consortia exhibit enhanced CO2 sequestration competence compared to commercial bovine CA
additional information
Micrococcus luteus 2
-
evaluation of efficiency of enzymes from Pseudomonas fragi, Micrococcus lylae, and Micrococcus luteus 2 compared to commercial Bos taurus carbonic anhydrase as biocatalysts in biomimetic sequestration of CO2 into CaCO3, the compared parameters are stability, inhibition rates by toxic metals, and pH dependency, overview. Indigenous carbonic anhydrases and their consortia exhibit enhanced CO2 sequestration competence compared to commercial bovine carbonic anhydrase
-
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
show the reaction diagram
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
show the reaction diagram
Helicobacter pylori, Helicobacter pylori 26695 (HP1186)
-
-
-
r
3-nitrophenyl acetate + H2O
3-nitrophenol + acetate
show the reaction diagram
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
P00915
-
-
r
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
r
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
r
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
r
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
r
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
r
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
r
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
-
-
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
r
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
r
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
r
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
r
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
P54212
-
-
r
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
Elephas trogontherii
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
Bacillus subtilis SA3
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
Helicobacter pylori 26695 (HP1186)
-
-
-
r
4-nitrophenyl acetate + H2O
4-nitrophenol + ?
show the reaction diagram
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + ?
show the reaction diagram
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
show the reaction diagram
-
-
-
?
4-nitrophenyl sulfate + H2O
4-nitrophenol + sulfate
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
Lupinus sp.
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
Q9WVT6
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
Q50940
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
Q7T2K6
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
Macropus eugenii desmarest
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
Melilotus sp.
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
Coccomyxa sp.
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
O14939
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
Q6R4A2
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
O43570, Q16790, Q9ULX7
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
Q16790
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
Q8N1Q1
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
B5SU02, -
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-, Q8FVP0
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
P53615, -
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-, Q8KJM6
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
P35219
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
among the seven known isozymes carbonic anhydrase III is the least efficient in catalytic hydration of CO2
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
periplasmic alpha-carbonic anhydrase activity of Helicobacter pylori is essential for acid acclimation
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
-
roles for residues 7, 62, and 67 in finetuning the properties of His64 for optimal proton transfer in catalysis
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
Azospirillum brasilense Sp7
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
Neisseria sicca 6021
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
Neisseria sicca 6021
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
Bacillus subtilis SA3
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
Q8KJM6
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
Pyrococcus horikoshii OT-3
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
Chlamydomonas reinhardtii D66
-
-
-
-
r
COS + H2O
CO2 + H2S
show the reaction diagram
-
-
-
-
?
CS2 + 2 H2O
CO2 + 2 H2S
show the reaction diagram
-
-
-
-
?
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
Q9D6N1
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
?
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
P00918
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
P00915
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
O43570
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-, Q8W183
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
P40881
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
?
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
P14141
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
P54212
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
P61517
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
P16016
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
Q8FVP0
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-, P45148
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
essential physiological function is to catalyze the hydration of carbon dioxide and the backreaction, the dehydration of bicarbonate
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-, Q8W183
plays a role in the hypersensitive defense response
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
plays a role in various physiological functions, including interconversion between CO2 and HCO3- in intermediary metabolism, facilitated diffusion of CO2, pH homeostasis and ion transport
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
CsoSCA converts HCO3- to CO2 for use in carbon fixation by ribulose-bisphosphate carboxylase/oxygenase
-
-
?
H2CO3
CO2 + H2O
show the reaction diagram
-, P45148
bicarbonate binding mode and binding structure, overview
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
the proton transfer from a zinc-bound water molecule to the proton shuttle His64, along a hydrogen-bonded water network, limits the reaction velocity of CO2 hydration. The side chain of His64 occupies two conformations in wild-type HCA II, pointing inward toward the zinc or outward toward bulk solvent. The enzyme shows a significant extension of the effective active site of HCA II from the zinc-bound water at the base of the conical cavity in the enzyme to Lys170 near the rim of the cavity
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
Rattus norvegicus Sprague-Dawley
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
Q8FVP0
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
Micrococcus luteus 2
-
-
-
-
r
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
show the reaction diagram
-
-
-
-
?
H2CO3
CO2 + H2O
show the reaction diagram
Helicobacter pylori 26695 (HP1186)
-
-
-
r
additional information
?
-
-
-
-
-
-
additional information
?
-
-
esterase activity with p-nitrophenyl acetate
-
-
-
additional information
?
-
-
esterase activity with p-nitrophenyl acetate
-
-
-
additional information
?
-
-
esterase activity with p-nitrophenyl acetate
-
-
-
additional information
?
-
-
esterase activity with p-nitrophenyl acetate
-
-
-
additional information
?
-
-
acetate esterase activity, p-nitrophenyl phosphatase
-
-
-
additional information
?
-
-
p-nitrophenyl phosphatase
-
-
-
additional information
?
-
-
no esterase activity
-
-
-
additional information
?
-
-
esterase activity with umbelliferone acetate
-
-
-
additional information
?
-
-
esterase activity with fluorescein diacetate, erythrocyte carbonic anhydrase II, no activity with cat caecum enzyme and erythrocyte carbonic anhydrase I
-
-
-
additional information
?
-
-
weak esterase activity with p-nitrophenyl acetate
-
-
-
additional information
?
-
-
weak esterase activity with p-nitrophenyl acetate
-
-
-
additional information
?
-
-
CO2/HCO3- exchange
-
-
-
additional information
?
-
-
no esterase activity detected with p-phenylacetate as the substrate
-
?
additional information
?
-
-
carbonic anhydrase I, II and III are constitutive enzymes
-
-
-
additional information
?
-
-
carbonic anhydrase 2 is induced by high CO2 concentration, carbonic anhydrase 1 is induced by low and high CO2 concentration
-
-
-
additional information
?
-
-
carbonic anhydrase IV is possibly responsible for HCO3- secretion, the cytoplasmic form of carbonic anhydrase II is believed to play a role in pH regulation near apical ionic channels of the near apical carbonic anhydrase IV
-
-
-
additional information
?
-
-
the enzyme is induced by low CO2 conditions, the enzyme probably has an important role in adaption of this algal cell to low CO2 conditions. A possible role for the mitochondrial enzyme might be to function as a pH stabilizer to prevent alkalinization of the mitochondrial matrix at the onset of photorespiration. The enzyme could also be involved in the diffusion and transport of inorganic carbon species within the mitochondrial matrix as well as their efflux
-
-
-
additional information
?
-
Q9WVT6
the enzyme is involved in various physiological processess such as acid-base balance and transport of CO2 and ions
-
-
-
additional information
?
-
-
inducible by low levels of CO2
-
-
-
additional information
?
-
-
carbonic anhydrase does not influence the fast contractile kinetics characteristic of the extraocular muscles
-
-
-
additional information
?
-
-
carbonic anhydrase IV mediates buffering in the extracellular space in central nervous system
-
-
-
additional information
?
-
-
carbonic anhydrase XIV may facilitate CO2 removal from neural retina and modulate photoreceptor function
-
-
-
additional information
?
-
-
carbonic anhydrase XIV mediates buffering in the extracellular space in central nervous system
-
-
-
additional information
?
-
-
external carbonic anhydrase enables algal cells to utilize HCO3- as inorganic carbon source in case that CO2 is limited externally to the plasma membrane
-
-
-
additional information
?
-
-
in mortality bioassays, carbonic anhydrase protects Tribolium castaneum from the toxicity of COS but has the opposite effect on COS toxicity. With CS2, carbonic anhydrase has a very minor role, neither facilitating, nor protecting against toxicity
-
-
-
additional information
?
-
-
the enzyme might play a key role in maintenance of midgut pH
-
-
-
additional information
?
-
-
the Na+/H+ antiporter NHE1 is the major exporter of protons by skeletal muscle in recovery from a period of anoxia. It is essential for functioning carbonic anhydrase to be attached to NHE1 to activate it
-
-
-
additional information
?
-
-, P46510, Q84Y09, Q84Y10
carbonic anhydrase 1 carries out nonphotosynthetic functions, including lipid biosynthesis and antioxidant activity
-
-
-
additional information
?
-
-, P46510, Q84Y09, Q84Y10
carbonic anhydrase 2 provides bicarbonate for anapleurotic reactions involving nonphotosynthetic forms of phosphoenol pyruvate carboxylase in the cytosol of cells in both photosynthetic and nongreen tissues
-
-
-
additional information
?
-
-, P46510, Q84Y09, Q84Y10
carbonic anhydrase 3 is responsible for catalyzing the first step in the C4 pathway in the mesophyll cell cytosol
-
-
-
additional information
?
-
-
carbonic anhydrase II increases the activity of the human electrogenic Na+/HCO3- cotransporter
-
-
-
additional information
?
-
-
extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation
-
-
-
additional information
?
-
-
other carbonic anhydrase isoforms than the well-characterized betaCA1 may contribute to the CO2 transfer in the cell to the catalytic site of ribulose 1,5-bisphosphate carboxylase/oxygenase, other carbonic anhydrase isoforms than the well-characterized betaCA1 may contribute to the CO2 transfer in the cell to the catalytic site of ribulose 1·5-bisphosphate carboxylase/oxygenase
-
-
-
additional information
?
-
-
rn the erythrocyte, carbonic anhydrase is necessary to facilitate the transport of carbon dioxide out of the body
-
-
-
additional information
?
-
-
that carbonic anhydrase domain in alcyonarian is involved in the calcification process
-
-
-
additional information
?
-
-
rCsoSCA exhibits no detectable esterase activity when assayed spectrophotometrically with 4-nitrophenylacetate as a substrate
-
-
-
additional information
?
-
-
BCA II when incubated under mildly denaturing condition of GdnHCl concentration of 1.5 M and a pH of 3.5 (slightly below its isoelectric point), forms ordered aggregates that are characteristically distinct from amorphous aggregates
-
-
-
additional information
?
-
P16015
the renal carbonic anhydrase type III plays a role in proximal tubule dysfunction
-
-
-
additional information
?
-
-
the enzyme shows esterase activity with 4-nitrophenyl acetate
-
-
-
additional information
?
-
-
the enzyme also shows esterase activity in 4-nitrophenylacetate hydrolysis
-
-
-
additional information
?
-
-
the enzyme also shows esterase activity with 4-nitrophenylacetate as substrate
-
-
-
additional information
?
-
-
the enzyme shows esterase assay with 4-nitrophenyl acetate as substrate
-
-
-
additional information
?
-
-, P45148
type II beta-carbonic anhydrases have a characteristic triad of non-catalytic residues, i.e. Trp39, Arg64, and Tyr181 in HICA, about 8 A away from the active site zinc ion that can bind bicarbonate ion. The studied anion binding site along the dimerization interface of HICA is an escort site that represents an intermediate along the ingress/egress route of bicarbonate ion to/from the allosteric binding site, overview. The mechanism of sulfate activation of HICA is the result of sulfate ion competing for bicarbonate at this escort site, preventing passage of bicarbonate from bulk solution to its allosteric site. The noncatalytic bicarbonate ion is a negative allosteric effector that stabilizes an inactive, T-state conformation of the enzyme, where Asp44 displaces the catalytically essential zinc-bound water. Type II beta-CAs can also adopt an active, R-state conformation in which Asp44 pairs with Arg46, allowing the coordination of the catalytically essential water molecule to the active site zinc ion. The noncatalytic bicarbonate ion stabilizes the inactive T state. The steric bulk of the Val47 side chain displaces bicarbonate from the allosteric binding site in the R state, and thus provides the necessary steric coupling mechanism between the bicarbonate binding and the adopted allosteric state
-
-
-
additional information
?
-
Neisseria sicca 6021
-
weak esterase activity with p-nitrophenyl acetate
-
-
-
additional information
?
-
Flaveria bidentis Kuntze
P46510, Q84Y09, Q84Y10
carbonic anhydrase 1 carries out nonphotosynthetic functions, including lipid biosynthesis and antioxidant activity
-
-
-
additional information
?
-
Flaveria bidentis Kuntze
P46510, Q84Y09, Q84Y10
carbonic anhydrase 3 is responsible for catalyzing the first step in the C4 pathway in the mesophyll cell cytosol
-
-
-
additional information
?
-
Flaveria bidentis Kuntze
P46510, Q84Y09, Q84Y10
carbonic anhydrase 2 provides bicarbonate for anapleurotic reactions involving nonphotosynthetic forms of phosphoenol pyruvate carboxylase in the cytosol of cells in both photosynthetic and nongreen tissues
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
P35219
-
-
-
r
CO2 + H2O
H2CO3
show the reaction diagram
-
periplasmic alpha-carbonic anhydrase activity of Helicobacter pylori is essential for acid acclimation
-
-
?
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
Q9D6N1
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
P00918
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
P00915
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
O43570
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
P40881
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
P14141
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
P54212
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
P61517
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
P16016
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
Q8FVP0
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-, P45148
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
essential physiological function is to catalyze the hydration of carbon dioxide and the backreaction, the dehydration of bicarbonate
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-, Q8W183
plays a role in the hypersensitive defense response
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
plays a role in various physiological functions, including interconversion between CO2 and HCO3- in intermediary metabolism, facilitated diffusion of CO2, pH homeostasis and ion transport
-
r
H2CO3
CO2 + H2O
show the reaction diagram
-
CsoSCA converts HCO3- to CO2 for use in carbon fixation by ribulose-bisphosphate carboxylase/oxygenase
-
-
?
H2CO3
CO2 + H2O
show the reaction diagram
Rattus norvegicus Sprague-Dawley
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
Q8FVP0
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
Micrococcus luteus 2
-
-
-
-
r
H2CO3
CO2 + H2O
show the reaction diagram
Helicobacter pylori 26695 (HP1186)
-
-
-
r
additional information
?
-
-
carbonic anhydrase I, II and III are constitutive enzymes
-
-
-
additional information
?
-
-
carbonic anhydrase 2 is induced by high CO2 concentration, carbonic anhydrase 1 is induced by low and high CO2 concentration
-
-
-
additional information
?
-
-
carbonic anhydrase IV is possibly responsible for HCO3- secretion, the cytoplasmic form of carbonic anhydrase II is believed to play a role in pH regulation near apical ionic channels of the near apical carbonic anhydrase IV
-
-
-
additional information
?
-
-
the enzyme is induced by low CO2 conditions, the enzyme probably has an important role in adaption of this algal cell to low CO2 conditions. A possible role for the mitochondrial enzyme might be to function as a pH stabilizer to prevent alkalinization of the mitochondrial matrix at the onset of photorespiration. The enzyme could also be involved in the diffusion and transport of inorganic carbon species within the mitochondrial matrix as well as their efflux
-
-
-
additional information
?
-
Q9WVT6
the enzyme is involved in various physiological processess such as acid-base balance and transport of CO2 and ions
-
-
-
additional information
?
-
-
inducible by low levels of CO2
-
-
-
additional information
?
-
-
carbonic anhydrase does not influence the fast contractile kinetics characteristic of the extraocular muscles
-
-
-
additional information
?
-
-
carbonic anhydrase IV mediates buffering in the extracellular space in central nervous system
-
-
-
additional information
?
-
-
carbonic anhydrase XIV may facilitate CO2 removal from neural retina and modulate photoreceptor function
-
-
-
additional information
?
-
-
carbonic anhydrase XIV mediates buffering in the extracellular space in central nervous system
-
-
-
additional information
?
-
-
external carbonic anhydrase enables algal cells to utilize HCO3- as inorganic carbon source in case that CO2 is limited externally to the plasma membrane
-
-
-
additional information
?
-
-
in mortality bioassays, carbonic anhydrase protects Tribolium castaneum from the toxicity of COS but has the opposite effect on COS toxicity. With CS2, carbonic anhydrase has a very minor role, neither facilitating, nor protecting against toxicity
-
-
-
additional information
?
-
-
the enzyme might play a key role in maintenance of midgut pH
-
-
-
additional information
?
-
-
the Na+/H+ antiporter NHE1 is the major exporter of protons by skeletal muscle in recovery from a period of anoxia. It is essential for functioning carbonic anhydrase to be attached to NHE1 to activate it
-
-
-
additional information
?
-
-, P46510, Q84Y09, Q84Y10
carbonic anhydrase 1 carries out nonphotosynthetic functions, including lipid biosynthesis and antioxidant activity
-
-
-
additional information
?
-
-, P46510, Q84Y09, Q84Y10
carbonic anhydrase 2 provides bicarbonate for anapleurotic reactions involving nonphotosynthetic forms of phosphoenol pyruvate carboxylase in the cytosol of cells in both photosynthetic and nongreen tissues
-
-
-
additional information
?
-
-, P46510, Q84Y09, Q84Y10
carbonic anhydrase 3 is responsible for catalyzing the first step in the C4 pathway in the mesophyll cell cytosol
-
-
-
additional information
?
-
-
carbonic anhydrase II increases the activity of the human electrogenic Na+/HCO3- cotransporter
-
-
-
additional information
?
-
-
extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation
-
-
-
additional information
?
-
-
other carbonic anhydrase isoforms than the well-characterized betaCA1 may contribute to the CO2 transfer in the cell to the catalytic site of ribulose 1,5-bisphosphate carboxylase/oxygenase, other carbonic anhydrase isoforms than the well-characterized betaCA1 may contribute to the CO2 transfer in the cell to the catalytic site of ribulose 1·5-bisphosphate carboxylase/oxygenase
-
-
-
additional information
?
-
-
rn the erythrocyte, carbonic anhydrase is necessary to facilitate the transport of carbon dioxide out of the body
-
-
-
additional information
?
-
-
that carbonic anhydrase domain in alcyonarian is involved in the calcification process
-
-
-
additional information
?
-
-
BCA II when incubated under mildly denaturing condition of GdnHCl concentration of 1.5 M and a pH of 3.5 (slightly below its isoelectric point), forms ordered aggregates that are characteristically distinct from amorphous aggregates
-
-
-
additional information
?
-
P16015
the renal carbonic anhydrase type III plays a role in proximal tubule dysfunction
-
-
-
additional information
?
-
Flaveria bidentis Kuntze
P46510, Q84Y09, Q84Y10
carbonic anhydrase 1 carries out nonphotosynthetic functions, including lipid biosynthesis and antioxidant activity
-
-
-
additional information
?
-
Flaveria bidentis Kuntze
P46510, Q84Y09, Q84Y10
carbonic anhydrase 3 is responsible for catalyzing the first step in the C4 pathway in the mesophyll cell cytosol
-
-
-
additional information
?
-
Flaveria bidentis Kuntze
P46510, Q84Y09, Q84Y10
carbonic anhydrase 2 provides bicarbonate for anapleurotic reactions involving nonphotosynthetic forms of phosphoenol pyruvate carboxylase in the cytosol of cells in both photosynthetic and nongreen tissues
-
-
-
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Ca2+
-
the native enzyme contains four Ca2+ ions
Cd2+
-
the enzyme uses cadmium as a catalytic metal atom
Cd2+
-
106.6% relative activity at 1 mM
Cd2+
-
replacement of zinc ion with cadmium does not entail significant differences in the catalytic performance of the enzyme
Co2+
Macropus eugenii desmarest
-
when added back to the apoenzyme in a 1:1 molar ratio or greater, the activity immediately returns to control level
Co2+
-
the Co2+-enzyme shows a definite propensity for five-coordination
Co2+
-
isomorphously replaces zinc
Co2+
-
can substitute for Zn2+
Co2+
-
cobalt is bound with a 1:1 stoichiometry
Co2+
-
can substitute for Zn2+
Co2+
-
Co2+ containing
Co2+
-
strongly activating effect, Co2+ induces an increase in the kcat/Km value
Co2+
-
305% activity at 1 mM
Co2+
-
removal of Zn2+ and preparation of Co(II)-substituted carbonic anhydrase II, Co(II)-HCA II. Change in metal coordination from tetrahedral at pH 11.0 to a coordination consistent with a mixed population of both tetrahedral and penta-coordinate at pH 8.5 to an octahedral geometry characteristic of the oxidized enzyme Co(III)-HCA II at pH 6.0
Co2+
-
preparation of a Co(II)-substituted HICA, Co-HICA. Co(II)-substituted HICA, Co-HICA, has comparable, 20% enhanced kcat and 2.3fold increased Km/kcat compared to that of the wild-type enzyme
Cu2+
-
binds copper about 50fold more tightly than zinc
Cu2+
-
CAII binds 2 copper ions
Cu2+
-
165% activity at 1 mM
Fe2+
-
contains one iron ion per monomer when synthesized in Methanosarcina acetivorans
Fe2+
-
102.6% relative activity at 1 mM
Fe3+
-
281% activity at 1 mM
KCl
-
enzyme retains activity at salt concentrations ranging from low salt to at least 1.5 M NaCl or KCl for CO2 hydration, 2.0 M NaCl for esterase activity and 0.5 M for bicarbonate dehydration
Mg2+
-
strongly activating effect, Mg2+ induces an increase in the kcat/Km value
Mg2+
-
107% activity at 1 mM
Mn2+
-
required
NaCl
-
enzyme retains activity at salt concentrations ranging from low salt to at least 1.5 M NaCl or KCl for CO2 hydration, 2.0 M NaCl for esterase activity and 0.5 M for bicarbonate dehydration
Ni2+
Macropus eugenii desmarest
-
slight activation of the apoenzyme
Ni2+
-
-
SO42-
-
126% activity at 1 mM
sulfate
-, P45148
the sulfate ion competes with the bicarbonate ion for the binding site near the active site affecting the allosteric regulation of the enzyme, binding structure in wild-type an dmutant enzymes, overview
Zinc
-
0.8 gatom of zinc per protein subunit
Zinc
-
required for activity and stability
Zinc
Macropus eugenii desmarest
-
Zn2+, when added back to the apoenzyme in a 1:1 molar ratio or greater, the activity immediately returns to control level
Zinc
-
enzyme contains 1 gatom of zinc per 27000 MW monomer
Zinc
-
essential for activity
Zinc
-
contains 1 gatom of zinc per subunit
Zinc
-
-
Zinc
-
contains 0.81 gatom of zinc per mol of enzyme, carbonic anhydrase A
Zinc
-
contains 5-6 gatom of zinc per mol of hexamer
Zinc
-
the major enzyme form contains 1 gatom of zinc per 30000 Da enzyme, the minor enzyme form contains 1.09 gatom of zinc per 30000 Da enzyme
Zinc
-
contains 1 gatom of tightly bound zinc per molecule
Zinc
-
contains 0.92 zinc ions per protein molecule with 28600 Da
Zinc
-
contains 6 mol of zinc per mol of enzyme
Zinc
-
the Zn2+ enzyme remains essentially fourcoordinate in all its forms, although alterations in the K-edge shape imply differences in coordination geometry
Zinc
-
contains 1 Zn per subunit
Zinc
-
total coordination number 4-6
Zinc
-, P83299
zinc metalloenzymes
Zn
-
Zn metalloenzyme
Zn2+
-
zinc-metalloenzyme
Zn2+
-
zinc-containing enzyme
Zn2+
-
zinc-containing enzyme
Zn2+
-
zinc bound water molecule of the enzyme
Zn2+
-
zinc-containing enzyme
Zn2+
-
zinc is bound with a 1:1 stoichiometry
Zn2+
-
thermodynamics of metal-binding
Zn2+
-
zinc-activated variant
Zn2+
-
zinc enzyme
Zn2+
-
zinc-containing metalloenzyme
Zn2+
-
zinc-containing metalloenzyme
Zn2+
-
active site zinc ion
Zn2+
-
zinc metalloenzyme
Zn2+
Q50565
zinc hydroxide mechanism
Zn2+
P16016
zinc hydroxide mechanism
Zn2+
-
zinc-hydroxide mechanism of catalysis
Zn2+
-
zinc-containing enzyme
Zn2+
-
zinc-containing enzyme
Zn2+
-
zinc-metalloenzyme
Zn2+
-
zinc enzyme
Zn2+
Q8W183
-
Zn2+
-
active-site zinc
Zn2+
-
monomer contains a single Zn2+
Zn2+
-
addition of 1 mM ZnCl2 to the metal-depleted enzyme restores the ctivity to nearly the level observed for nondialyzed samples, while neither CoCl2 nor MgCl2 is able to reverse the inactivation of the enzyme. Zn2+ contents of 0.9 mol of Zn2+ per mol of monomer
Zn2+
-
addition of zinc improves the CO2 hydration activity of the rice CA produced by Escherichia coli
Zn2+
-
zinc-containing metalloenzyme, the asymmetric unit contains a catalytic Zn2+ ion
Zn2+
-
zinc metalloenzyme
Zn2+
-
contains one zinc ion per monomer when overproduced in Escherichia coli
Zn2+
-
strongly activating effect, the recombinant extracellular domain of CA IX, which includes both the proteoglycan and catalytic domains, shows 2166% increase of activity in the presence of 0.05 mM Zn2+
Zn2+
-
the holoenzyme contains Zn2+
Zn2+
-
contains one Zn2+ per monomer
Zn2+
-
Cd2+ can be substituted by Zn2+, yielding an even more efficient enzyme
Zn2+
-
contains zinc
Zn2+
-
zinc metalloenzyme
Zn2+
-
contains Zn2+
Zn2+
-
zinc-metalloenzyme
Zn2+
-
zinc-containing enzyme
Zn2+
-
473% activity at 1 mM
Zn2+
-
zinc-containing enzyme
Zn2+
P53615, -
a zinc ion is coordinated by the three highly conserved residues Cys57, His112 and Cys115
Zn2+
-, Q8KJM6
zinc-containing metalloenzyme
Zn2+
-
109.25% relative activity at 1 mM
Zn2+
-
two Zn atoms in the alphaCA1 crystal asymmetric unit
Zn2+
-
required. The side chain of Tyr7 in HCA II extends into the active-site cavity about 7 A from the catalytic zinc atom
Zn2+
-
required, can be substituted by Co2+
Zn2+
-, P45148
a zinc-metalloenzyme
Zn2+
-
required for catalysis, the side chain of His64 occupies two conformations in wild-type HCA II, pointing inward toward the zinc or outward toward bulk solvent
Zn2+
-
a zinc metalloenzyme
Zn2+
A7DX12, A7DX13, -
required, binding structure modelling, overview; required, binding structure modelling, overview
Zn2+
-
required
Zn2+
Q8FVP0
beta class CAs contain four protein zinc ligands, one His, two Cys, and one Asp coordinated to Zn(II). At pH 8.0, no water is coordinated to the metal ion
Zn2+
-
catalytically crucial
Zn2+
-
required, isozymes CAH-3, CAH-4 and CAH-5 contain the three zinc-binding histidines that are important for enzyme activity, His94, His96, and His119, and also two ligands that provide a hydrogen bond to stabilize the zinc ion during catalysis, Gln-92 and Glu-117
Zn2+
-
active site bound and essential for catalysis, metalloenzyme
Zn2+
-
required for activity. Replacement of zinc ion with cadmium does not entail significant differences in the catalytic performance of the enzyme
Zn2+
-
required, increases the growth rate of the cells and the enzyme activity
Mn2+
-
strongly activating effect, Mn2+ induces an increase in the kcat/Km value
additional information
-
not influenced by Cu2+, K+, Na+, Ca2+, and Mg2+
additional information
-
the enzyme shows an optimum ionic strength at 10mM
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
(2,4,6-triisopropylphenyl)sulfonylsulfamic acid
-
-
(2,4,6-tripropylphenyl)sulfonylsulfamic acid
-
-
(2,5-dichlorophenyl)sulfonylsulfamic acid
-
-
(2-nitrophenyl)sulfonylsulfamic acid
-
-
(2E)-4-methoxy-4-oxobut-2-enoic acid
-
-
(2E)-but-2-enedioic acid
-
-
(2R)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid
-
-
(2S)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid
-
-
(3,5-dichloro-2-hydroxyphenyl)sulfonylsulfamic acid
-
-
(3-chloro-4-hydroxyphenyl)acetic acid
-
-
(3-chloro-4-nitrophenyl)sulfonylsulfamic acid
-
-
(3-chlorophenyl)(2-thioxo-1H-benzo[d]imidazol-1-yl)methanone
-
-
(3-chlorophenyl)acetic acid
-
-
(3-nitrophenyl)sulfonylsulfamic acid
-
-
(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate (non-preferred name)
-
-
-
(4-acetylphenyl)sulfonylsulfamic acid
-
-
(4-bromophenyl)sulfonylsulfamic acid
-
-
(4-chlorophenyl)sulfonylsulfamic acid
-
-
(4-fluorophenyl)sulfonylsulfamic acid
-
-
(4-hydroxyphenyl)acetic acid
-
-
(4-iodophenyl)sulfonylsulfamic acid
-
-
(4-methoxyphenyl)sulfonylsulfamic acid
-
-
(4-methylphenyl)sulfonylsulfamic acid
-
-
(4-nitrophenyl)sulfonylsulfamic acid
-
-
(5Z)-2-amino-5-(3,4-dihydroxybenzylidene)-3,5-dihydro-4H-imidazol-4-one
-
-
(5Z)-2-amino-5-(4-hydroxy-3-methoxybenzylidene)-3,5-dihydro-4H-imidazol-4-one
-
-
(6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
-
(E)-3-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)prop-2-en-1-one
-
36% inhibition
(heptadecafluorooctyl)sulfonylsulfamic acid
-
-
(nonafluorobutyl)sulfonylsulfamic acid
-
-
(pentafluorophenyl)sulfonylsulfamic acid
-
-
(trichloromethyl)sulfonylsulfamic acid
-
-
(trifluoromethyl)sulfonylsulfamic acid
-
-
1,1,1-trifluoromethanesulfonamide
Q16790
-
1,1,2,2,3,3,4,4 octafluoro-n-butane-1-4-bissulfonamide
-
-
1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-n-hexane-1-sulfonamide
-
-
1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-n-heptane-1-sulfonamide
-
-
1,1,2,2,3,3,4,4-octafluoro-n-butane-1-4-bissulfonamide
-
-
1,1-dimethyl-4-(7-sulfamoyl-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazol-3-yl)piperazin-1-ium iodide
Q16790
-
1,2,4-trimethoxybenzene
-
-
1,2-benzothiazol-3(2H)-one 1,1-dioxide
-
-
1,2-bis[(2,4-dichloro-5-sulfonamidobenzamide)ethoxy]ethane
-
-
1,2-bis[(2,4-dichloro-5-sulfonamidobenzoate)-ethoxy]ethane
-
-
1,2-bis[(4-sulfonamidobenzamide)ethoxy]ethane
-
-
1,2-bis[(4-sulfonamidobenzoate)ethoxy]ethane
-
-
1,2-dimethoxybenzene
-
-
1,2:3,4-di-O-isopropylidene-alpha-D-galactopyranose 6-sulfamate
-
-
1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose 3-sulfamate
-
-
1,3-benzoxazole-2(3H)-thione
-
-
1,3-diacetyl-1H-benzo[d]imidazol-2(3H)-one
-
10% inhibition
1,3-diacetylbenzimidazole-2-thione
-
-
1,3-dihydro-2H-benzimidazole-2-thione
-
-
1,3-dioxolan-2-yl-N-(2-propenyl)-2-thiophene-sulfonamide
-
-
1,4-dimethoxybenzene
-
-
1-(1,2-benzoxazol-3-yl)methanesulfonamide
-
-
1-(2-thioxo-1H-benzo[d]imidazol-1-yl)-3-phenylpropan-1-one
-
-
1-(2-thioxo-1H-benzo[d]imidazol-1-yl)ethanone
-
-
1-(2-thioxo-1H-benzo[d]imidazol-1-yl)hexan-1-one
-
-
1-(2-thioxo-1H-benzo[d]imidazol-1-yl)propan-1one
-
-
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)decan-1-one
-
-
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone
-
-
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)hexadecan-1-one
-
-
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)hexan-1-one
-
-
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one
-
-
1-(2-Tthioxo-1H-benzo[d]imidazol-1-yl)butan-1-one
-
-
1-(3-acetyl-1,2-dihydro-2-thioxobenzo[d]imidazol-1-yl)hexan-1-one
-
-
1-(3-ethyl-1,2-dihydro-2-thioxobenzo[d]imidazole-1-yl)ethanone
-
-
1-cyclohexyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
;
1-cyclopentyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
;
1-cyclopropyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
;
1-ethyl-1H-benzo[d]imidazole-2(3H)-thione
-
28% inhibition
1-n-butyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
;
1-naphthylsulfonylsulfamic acid
-
-
1-[(2-oxo-2H-chromen-6-yl)methyl]-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane
-
-
1-[(aminooxy)sulfinyl]-4-methylbenzene
-
-
1-[4-[(aminooxy)sulfinyl]phenyl]methanamine
-
-
1H,1H,2H,2H-perfluorodecyl sulfamate
-
-
1H,1H,2H,2H-perfluorooctyl sulfamate
-
-
1H,1H-perfluoroethyl sulfamate
-
-
1H-perfluoroisopropyl sulfamate
-
-
2,3,4,5,6-pentafluoro-N-(2-sulfamoylphenyl)benzenesulfonamide
-
-
2,3,4,5,6-pentafluoro-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)benzamide
-
-
2,3,4,5,6-pentafluoro-N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]benzamide
-
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine
-
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine
-
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine
-
-
2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine
-
-
2,4,6-trichlorophenyl sulfamate
-
-
2,4-bis[(aminooxy)sulfinyl]-5-(trifluoromethyl)aniline
-
-
2,4-bis[(aminooxy)sulfinyl]-5-chloroaniline
-
-
2,4-Dichlorophenol
-
-
2,5-difluorophenol
-
-
2,6-dimethoxybenzoic acid
-
-
2-(1-methylethyl)-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(1-methylethyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide
-
noncompetitive inhibition
2-(2-hydroxyethyl)-N-(1,1-dimethylethyl)-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
2-(2-methoxyethyl)-3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(2-methoxyethyl)-3-[[bis(2-methoxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3,4-dimethoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-chloro-4-hydroxyphenyl)-N-(2-methoxyethyl)acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)-N-(2-phenylethyl)acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3-methoxyphenyl)ethyl]acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)acetamide
-
-
2-(3-chloropropionylamino)-1,3,4-thiadiazole-5-sulfonamide
-
noncompetitive inhibition
2-(3-hydroxyphenyl)-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(3-hydroxyphenyl)-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-hydroxypropyl)-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(3-methoxyphenyl)-3-[(2-hydroxyethylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-methoxypropyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(3-methoxypropyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
Q1CVF1, Q9WVT6
isoenzyme hpalphaCA; isoenzyme hpbetaCA
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
-
isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA XII; isoenzyme hCA XIV
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
-
isoenzyme gammaCA
2-(3-phenylpropionylamino)-1,3,4-thiadiazole-5-sulfonamide
-
noncompetitive inhibition
2-(4-hydroxyphenyl)acetamide
-
-
2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(2-sulfamoylphenyl)acetamide
-
-
2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(3-sulfamoylphenyl)acetamide
-
-
2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(4-sulfamoylphenyl)acetamide
-
-
2-(benzenesulfonamido-N-benzyl)-5-[N,Ndibenzylsulfonamido]-l,3,4-thiadiazole
-
-
2-(benzenesulfonamido-N-benzyl)-l,3,4-thiadiazole-5-sulfonamide
-
-
2-(benzenesulfonamido-N-ethyl)-l,3,4-thiadiazole-5-sulfonamide
-
-
2-(benzenesulfonamido-N-methyl)-l,3,4-thiadiazole-5-sulfonamide
-
-
2-(benzenesulfonamido-N-phenethyl)-l,3,4-thiadiazole-5-sulfonamide
-
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide
O14939
isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV catalytic domain
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide
-
isoenzyme mCA XIII
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide
-
; efficient inhibitor of only isozymes CA I and II
2-(p-toluenesulfonamido)-l,3,4-thiadiazole-5-sulfonamide
-
-
-
2-(phenylethynyl)benzenesulfonamide
-
-
2-acetylamido-1,3,4-thiadiazole-5-sulfonamide
-
acetazolamide
2-adamantylethyl 7-methoxy-2-oxo-2H-chromene-8-carboxylate
-
-
2-amino-pyrimidin-4-yl-sulfanilamide
-
best inhibitor
2-aminobenzenesulfonamide
-
-
2-aminobenzenesulfonamide
-
-
2-aminobenzenesulfonamide
-
-
2-aminobenzenesulfonamide
-
-
2-aminobenzenesulfonamide
-
-
2-benzene-sulfonamido-l,3,4-thiadiazole-5-sulfonamide
-
-
-
2-cyclohexyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-cyclopropylmethyl-3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-ethyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-ethyl-3-[[bis(2-hydroxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-ethyl-3-[[bis(2-methoxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-hydrazinobenzenesulfonamide
-
-
2-hydrazinobenzenesulfonamide
-
-
2-hydrazinylbenzenesulfonamide
-
-
2-hydrazinylbenzenesulfonamide
-
-
2-hydroxycinnamic acid
-
-
2-mercaptoethanol
-
-
2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-methanol 1,1-dioxide
-
-
2-methyl-2H-thieno[3,2-e]-1,2-thiazine-3-methanol 1,1-dioxide
-
-
2-methyl-3-(4-morpholinylmethyl)-2H-thieno[2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
2-methyl-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-methyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-methyl-3-[[N-(2-methoxyethyl)-N-(2-propenyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-methyl-3-[[N-(2-methoxyethyl)-N-(3-methoxypropyl)-amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide
-
isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV
2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide
-
isoenzyme mCA XIII
2-N-(4-sulfamoylphenyl)-thioformyl-L-Ala
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Asn
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Gln
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Ile
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Leu
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Met
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Phe
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Pro
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Trp
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Val
-
-
2-naphthyl sulfamate
-
-
2-naphthylsulfamate
-
-
2-naphthylsulfonylsulfamic acid
-
-
2-nitrobenzenesulfonamide
-
-
2-Nitrophenol
-
product inhibition
2-oxo-2H-chromene-3-carboxylic acid
-
-
2-oxo-2H-thiochromene-3-carboxylic acid
-
-
2-oxo-N-(2-sulfamoylphenyl)-2H-chromene-3-carboxamide
-
-
2-oxo-N-(3-sulfamoylphenyl)-2H-chromene-3-carboxamide
-
-
2-oxo-N-(4-sulfamoylbenzyl)-2H-chromene-3-carboxamide
-
-
2-oxo-N-(4-sulfamoylphenyl)-2H-chromene-3-carboxamide
-
-
2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3-carboxamide
-
-
2-phenoxy-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone
-
-
2-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone
-
-
2-phenylethyl sulfamate
-
-
2-propyl-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-sulfonamido-1,3,4-thiadiazole-5-benzene sulfonamide
-
-
2-[(4-methoxyphenyl)methyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-[(4-methoxyphenyl)methyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-[(4-morpholinyl)phenyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-[(aminooxy)sulfinyl]-5-(2-chlorophenyl)-1,3,4-thiadiazole
-
-
2-[(aminooxy)sulfinyl]aniline
-
-
2-[(diphenylcarbamoyl)amino]benzenesulfonamide
-
-
2-[(p-toluenesulfonamido)-N-(2-methoxylphenylpropyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-(3,4,5-trimethoxylbenzyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-(4-bromobenzyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-(4-bromophenethyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-(4-chlorobenzyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-(4-fluorobenzyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-(4-methoxylbenzyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-(4-methylbenzyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-(i-butyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-(i-propyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-(n-butyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-(n-lauryl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-(n-pentyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-(n-propyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-benzyl]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-ethyl]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-methyl]-5-[N,N-dimethylsulfonamide]-l,3,4-thiadiazole
-
-
2-[(p-toluenesulfonamido)-N-methyl]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[(p-toluenesulfonamido)-N-phenethyl]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[2-(4-morpholinyl)ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
-
2-[2-(acetoxy)ethyl]-N-(1,1-dimethylethyl)-4-hydroxy-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
2-[2-(propylamino)ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
-
2-[2-[4-acetyl-(1-piperazinyl)]ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
2-[2-[bis(2-methoxyethyl)amino]ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
-
2-[4-(4-morpholinyl)-2-butenyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
-
2-[4-[(aminooxy)sulfinyl]phenyl]ethanamine
-
-
2-[4-[(aminooxy)sulfinyl]phenyl]ethanol
-
-
2-[benzenesulfonamido-N-(2,4-dichlorobenzyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[benzenesulfonamido-N-(3,4,5-trimethoxylbenzyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[benzenesulfonamido-N-(4-bromophenethyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[benzenesulfonamido-N-(4-chlorobenzyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[benzenesulfonamido-N-(4-methoxylbenzyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[benzenesulfonamido-N-(i-butyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[benzenesulfonamido-N-(i-propyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[benzenesulfonamido-N-(n-butyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[benzenesulfonamido-N-(n-lauryl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[benzenesulfonamido-N-(n-pentyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2-[benzenesulfonamido-N-(n-propyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2H-chromen-2-one
-
-
3,3,4,4,5,5,6,6,6-nonafluoro-n-hexanesulfonamide
-
-
3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-n-octanesulfonamide
-
-
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-n-decanesulfonamide
-
-
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine
-
-
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine
-
-
3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
;
3,4-dihydroxybenzoic acid
-
-
3,4-dimethoxybenzoic acid
-
-
3,5-dibromo-2-(1,3-dioxalan-2-yl)-thiophene
-
-
3,5-difluorophenol
-
-
3,5-Dihydroxybenzoic acid
-
-
3-(1,3-dioxolan-2-yl)-N-(2-methoxyethyl)-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-(3,4-dimethoxyethyl)-2-thiophenesulfonamide
-
-
-
3-(1,3-dioxolan-2-yl)-N-(3,4-dimethoxyphenyl)-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-(3-methoxyethyl)-2-thiophenesulfonamide
-
-
-
3-(1,3-dioxolan-2-yl)-N-(3-methoxyphenyl)-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-(4-(4-morpholinyl)phenyl)-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-cyclohexyl-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-[4-(4-morpholinyl)phenyl]-2-thiophenesulfonamide
-
-
3-(4-methylpiperazin-1-yl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
Q16790
-
3-(4-sulfamoylphenyl)propanoic acid
-
-
3-(4-sulfamoylphenyl)propanoic acid
-
-
3-(methylsulfanyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
Q16790
-
3-(methylsulfonyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
Q16790
-
3-(phenylethynyl)benzenesulfonamide
-
-
3-(phenylsulfanyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
Q16790
-
3-3-(1,3-dioxolan-2-yl)-N-(1-methylethyl)-2-thiophene-sulfonamide
-
-
3-acetylbenzo[d]oxazol-2(3H)-one
-
-
3-bromo-4-amino-benzenesulfonamide
-
-
3-bromosulfanilamide
-
-
3-chloro-4-amino-benzenesulfonamide
-
-
3-chloro-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
Q16790
-
3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
3-chloropropyl sulfamate
-
-
3-cyclohexyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one
-
-
3-ethylbenzo[d]oxazole-2(3H)-thione
-
17% inhibition
3-fluoro-4-amino-benzenesulfonamide
-
-
3-hexanoylbenzo[d]oxazol-2(3H)-one
-
-
3-Hydroxybenzoic acid
-
-
3-hydroxymethyl 2-methyl-2H-thieno[2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
3-hydroxymethyl-2-methyl-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
3-iodo-4-amino-benzenesulfonamide
-
-
3-methylphenylsulfamate
-
-
3-methylsalicylic acid
-
noncompetitive inhibition of isozyme carbonic anhydrase I and uncompetitive inhibition of isozyme carbonic anhydrase II
3-morpholin-4-yl-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
Q16790
-
3-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one
-
-
3-phenylprop-2-ene-1-sulfonamide
-
-
3-phenylpropanenitrile
-
-
3-tributylgermylpropanamine
-
-
3-triethylgermylpropanamine
-
-
3-triethylsilylpropanamine
-
-
3-triphenylgermylpropanamine
-
-
3-[(1-imidazolyl)methyl]-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
3-[(3-fluorophenyl)ethynyl]benzenesulfonamide
-
-
3-[(3-methoxyphenyl)ethynyl]benzenesulfonamide
-
-
3-[(4-methylphenyl)ethynyl]benzenesulfonamide
-
-
3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
3-[(4-morpholinyl)methyl]-2-propyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[(anilinocarbonyl)amino]benzenesulfonamide
Q16790, Q9ULX7
-
3-[(anilinocarbonyl)amino]benzenesulfonamide
-
-
3-[(cyclopropylamino)methyl]-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[(sulfoamino)sulfonyl]benzoic acid
-
-
3-[4-[(aminooxy)sulfinyl]phenyl]propanoic acid
-
-
3-[9-borabicyclo[1.3.3.]nonane]-1-bromopropane
-
-
3-[9-borabicyclo[1.3.3.]nonane]-1-propylsulfonic acid sodium salt
-
-
3-[[(aminosulfonyl)amino]sulfonyl]benzoic acid
-
-
3-[[bis(2-methoxyethyl)amino]methyl]-2-propyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[[N-(2-methoxyethyl)-N-(2-propenyl)amino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[[N-(2-methoxyethyl)-N-(3-methoxypropyl)amino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[[N-(2-methoxyethyl)-N-methylamino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
3alpha,12alpha-diacetoxy-5beta-cholan-24-oic acid
-
-
3alpha,7alpha,12alpha-triacetoxy-5beta-cholan-24-oic acid
-
-
3alpha-acetoxy-5beta-cholan-24-oic acid
-
-
4,4'-thiodipyridine-3-sulfonamide
-
-
4,4'-[(1R,2R,3S,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol)
-
-
4,4'-[(1R,2S,3R,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol)
-
-
4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol)
-
-
4,5-dichloro-benzene-1,3-disulfonamide
Q1CVF1, Q9WVT6
isoenzyme hpalphaCA, i.e. daranide; isoenzyme hpbetaCA, i.e. daranide
4,5-dichloro-benzene-1,3-disulfonamide
-
isoenzyme hCA I, i.e. daranide; isoenzyme hCA II, i.e. daranide; isoenzyme hCA III, i.e. daranide; isoenzyme hCA IV, i.e. daranide; isoenzyme hCA IX, i.e. daranide; isoenzyme hCA VA, i.e. daranide; isoenzyme hCA VB, i.e. daranide; isoenzyme hCA VI, i.e. daranide; isoenzyme hCA VII, i.e. daranide; isoenzyme hCA XII, i.e. daranide; isoenzyme hCA XIV, i.e. daranide
4,5-dichloro-benzene-1,3-disulfonamide
-
isoenzyme gammaCA, i.e. daranide
4,5-dichloro-benzene-1,3-disulfonamide
-
isoenzyme mCA XIII, i.e. daranide
4,5-dichloro-benzene-1,3-disulfonamide
-
shows effective carbonic anhydrase inhibitory activity
4,5-dichloro-benzene-1,3-disulfonamide
-
-
4,5-dichloro-benzene-1,3-disulfonamide
-
-
4,5-dichlorobenzene-1,3-disulfonamide
-
-
4,5-dichlorobenzene-1,3-disulfonamide
-
-
4,6-dinitrosalicylic acid
-
noncompetitive inhibition of isozymes carbonic anhydrase I and II
4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide
-
-
4-(1,3,4-thiadiazol-2-ylthio)pyridine-3-sulfonamide
-
-
4-(1-methyl-5-tetrazolylthio)pyridine-3-sulfonamide
-
-
4-(2-amino-pyrimidin-4-yl)-benzenesulfonamide
-
best inhibitor
4-(2-amino-pyrimidin-4-yl)-benzenesulfonamide
-
-
4-(2-amino-pyrimidin-4-yl)-benzenesulfonamide
-
-
4-(2-aminoethyl)benzenesulfonamide
-
-
4-(2-aminoethyl)benzenesulfonamide
-
-
4-(2-aminoethyl)benzenesulfonamide
-
-
4-(2-aminoethyl)benzenesulfonamide
-
-
4-(2-aminoethyl)benzenesulfonamide
-
-
4-(2-hydroxyethyl)benzenesulfonamide
-
-
4-(2-hydroxyethyl)benzenesulfonamide
-
-
4-(2-hydroxyethyl)benzenesulfonamide
-
-
4-(2-hydroxyethyl)benzenesulfonamide
-
-
4-(2-hydroxyethyl)benzenesulfonamide
-
-
4-(2-hydroxyethyl)phenol
-
-
4-(2-methyl-8-quinolinoxy)-3-pyridinesulfonamide
-
-
4-(2-phenylacetamido)-3-bromobenzenesulfonamide
-
-
4-(2-phenylacetamido)-3-chlorobenzenesulfonamide
-
-
4-(2-phenylacetamido)-3-fluorobenzenesulfonamide
-
-
4-(2-phenylacetamido)benzenesulfonamide
-
-
4-(2-phenylacetamidoethyl)benzenesulfonamide
-
-
4-(2-phenylacetamidomethyl)benzenesulfonamide
-
-
4-(2-propynylthio)pyridine-3-sulfonamide
-
-
4-(2-pyridin-2-ylacetamido)benzenesulfonamide
-
-
4-(2-pyridin-4-ylacetamido)benzenesulfonamide
-
-
4-(2-pyridin-4-ylacetamidoethyl)benzenesulfonamide
-
-
4-(3,4-dichlorophenylureido)thioureido-benzenesulfonamide
-
effective in vitro carbonic anhydrase inhibitor
4-(3-[[(1E)-(1-methyl-1H-imidazol-2-yl)methylidene]amino]propyl)benzenesulfonamide
-
-
4-(4'-dimethylaminophenyl)diazenylbenzenesulfonamide
-
-
4-(4'-hydroxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide
-
-
4-(4'-hydroxyphenyl)diazenylbenzene-N-methylsulfonamide
-
-
4-(4'-hydroxyphenyl)diazenylbenzenesulfonamide
-
-
4-(4'-methoxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide
-
-
4-(4-cyanophenoxy)-3-pyridinesulfonamide
-
-
4-(4-fluorophenoxy)-3-pyridinesulfonamide
-
-
4-(4-sulfanilyl-aminoethyl)-benzenesulfonamide
-
-
4-(4-sulfanilyl-aminomethyl)-benzenesulfonamide
-
-
4-(5-methyl-2-pyrazolino)-3-pyridinesulfonamide
-
-
4-(6-nitrobenzothiazol-2-ylthio)pyridine-3-sulfonamide
-
-
4-(allylamino)-3-pyridinesulfonamide
-
-
4-(aminomethyl)benzenesulfonamide
-
-
4-(aminomethyl)benzenesulfonamide
-
-
4-(aminomethyl)benzenesulfonamide
-
-
4-(aminomethyl)benzenesulfonamide
-
-
4-(aminomethyl)benzenesulfonamide
-
-
4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide
Q16790, Q9ULX7
-
4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide
-
-
4-(aminosulfonyl)-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzamide
-
-
4-(aminosulfonyl)benzoic acid
-
-
4-(carbamothioylamino)benzenesulfonamide
-
-
4-(carbamoylmethylthio)pyridine-3-sulfonamide
-
-
4-(carboxyethyl)-benzenesulfonamide
-
-
4-(cyanomethylthio)pyridine-3-sulfonamide
-
-
4-(ethylamino)-6-(3-methoxypropyl)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
-
4-(hydroxymethyl)benzenesulfonamide
-
-
4-(hydroxymethyl)benzenesulfonamide
-
-
4-(hydroxymethyl)benzenesulfonamide
-
-
4-(hydroxymethyl)benzenesulfonamide
-
-
4-(hydroxymethyl)benzenesulfonamide
-
-
4-(methylhydrazino)-3-pyridinesulfonamide
-
-
4-(N-oxide-2-pyridylthio)pyridine-3-sulfonamide
-
-
4-(phenylethynyl)benzenesulfonamide
-
-
4-(quinolinoxy)-3-pyridinesulfonamide
-
-
4-([(1E)-[4-(dimethylamino)phenyl]methylidene]amino)benzenesulfonamide
-
-
4-([[(1Z)-(2-chlorophenyl)methylidene]amino]methyl)benzenesulfonamide
-
-
4-([[(diethyl-l5-azanylidyne)methyl]disulfanyl]amino)benzenesulfonamide
-
-
4-acetyl-N-(aminosulfonyl)benzenesulfonamide
-
-
4-acetylamidophenyl sulfamate
-
-
4-amino-3,5-dibromobenzenesulfonamide
-
-
4-amino-3,5-dibromobenzenesulfonamide
-
-
4-amino-3,5-dibromobenzenesulfonamide
-
-
4-amino-3,5-diiodobenzenesulfonamide
-
-
4-amino-3,5-diiodobenzenesulfonamide
-
-
4-amino-3-bromobenzenesulfonamide
-
-
4-amino-3-bromobenzenesulfonamide
-
-
4-amino-3-bromobenzenesulfonamide
-
-
4-amino-3-bromobenzenesulfonamide
-
-
4-amino-3-chlorobenzenesulfonamide
-
-
4-amino-3-chlorobenzenesulfonamide
-
-
4-amino-3-chlorobenzenesulfonamide
-
-
4-amino-3-chlorobenzenesulfonamide
-
-
4-amino-3-chlorobenzenesulfonamide
-
-
4-amino-3-fluoro-5-iodobenzenesulfonamide
-
-
4-amino-3-fluorobenzenesulfonamide
-
-
4-amino-3-fluorobenzenesulfonamide
-
-
4-amino-3-fluorobenzenesulfonamide
-
-
4-amino-3-fluorobenzenesulfonamide
-
-
4-amino-3-fluorobenzenesulfonamide
-
-
4-amino-3-iodobenzenesulfonamide
-
-
4-amino-3-iodobenzenesulfonamide
-
-
4-amino-3-iodobenzenesulfonamide
-
-
4-amino-3-iodobenzenesulfonamide
-
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
-
4-amino-6-chloro-benzene-1,3-disulfonamide
-
-
4-amino-6-chlorobenzene-1,3-disulfonamide
-
-
4-amino-6-chlorobenzene-1,3-disulfonamide
-
-
4-amino-6-chlorobenzene-1,3-disulfonamide
-
-
4-amino-6-chlorobenzene-1,3-disulfonamide
-
-
4-amino-6-chlorobenzene-1,3-disulfonamide
-
-
4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide
-
-
4-amino-benzenesulfonamide
-
-
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
-
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
-
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
-
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
-
4-amino-N-[4-(aminosulfonyl)benzyl]benzenesulfonamide
-
-
4-amino-N-[4-[(aminooxy)sulfinyl]benzyl]benzenesulfonamide
-
-
4-amino-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzenesulfonamide
-
-
4-Aminobenzenesulfonamide
-
-
4-Aminobenzenesulfonamide
-
-
4-Aminobenzenesulfonamide
-
-
4-Aminobenzenesulfonamide
-
-
4-Aminobenzenesulfonamide
-
-
4-Aminobenzenesulfonamide
-
-
4-aminoethyl-benzenesulfonamide
-
carbonic anhydrase XIII
4-aminoethyl-benzenesulfonamide
-
-
4-aminoethylbenzenesulfonamide
Q16790, Q9ULX7
-
4-aminomethyl-benzenesulfonamide
-
-
4-Aminophenol
-
-
4-aminosalicylic acid
-
noncompetitive inhibition of isozymes carbonic anhydrase I and II
4-benzythiopyridine-3-sulfonamide
-
-
4-bromo-5-(1,3-dioxalan-2-yl)-N-(1,1-dimethylethyl)-thiophene-2-sulfonamide
-
-
4-bromobenzenesulfonamide
-
-
4-bromophenyl sulfamate
-
-
4-carboxy-benzenesulfonamide
-
-
4-chlorobenzenesulfonamide
-
-
4-chlorophenyl sulfamate
-
best CA IX inhibitor
4-chlorophenyl sulfamate
Q8FVP0
-
4-cyanophenyl sulfamate
-
-
4-ethoxy-3-pyridinesulfonamide
-
-
4-ethynylbenzenesulfonamide
-
-
4-fluorobenzenesulfonamide
-
-
4-hydrazino-3-pyridinesulfonamide
-
-
4-hydrazinobenzenesulfonamide
-
-
4-hydrazinobenzenesulfonamide
-
-
4-hydrazinylbenzenesulfonamide
-
-
4-hydrazinylbenzenesulfonamide
-
-
4-hydroxybenzenesulfonamide
-
-
4-hydroxybenzoic acid
-
-
4-Hydroxybenzonitrile
-
-
4-hydroxyethyl-benzenesulfonamide
-
-
4-hydroxymethyl-benzenesulfonamide
-
-
4-iodobenzenesulfonamide
-
-
4-iodobenzenesulfonamide
-
-
4-iodophenyl sulfamate
-
-
4-methoxy-3-pyridinesulfonamide
-
-
4-methoxyphenyl sulfamate
-
-
4-methyl-5-imino-1,3,4-thiadiazoline-2-sulfonamide
-
-
4-methyl-benzenesulfonamide
-
-
4-methylbenzenesulfonamide
-
-
4-methylbenzenesulfonamide
-
-
4-methylbenzenesulfonamide
-
-
4-methylbenzenesulfonamide
-
-
4-methylbenzenesulfonamide
-
-
4-methylphenyl sulfamate
-
-
4-methylthiopyridine-3-sulfonamide
-
-
4-nitrobenzenesulfonamide
-
-
4-nitrophenyl sulfamate
-
-
4-phenoxyphenyl sulfamate
-
-
4-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)butan-1-one
-
-
4-phenylphenyl sulfamate
-
-
4-S-isobutylamino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
binds 800 times more strongly to carbonic anhydrase II than to carbonic anhydrase I
4-sulfamoyl-N-(4-sulfamoylphenyl)benzamide
-
-
4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
-
-
4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
-
-
4-sulfamoylbenzoic acid
-
-
4-sulfamoylbenzoic acid
-
-
4-sulfamoylbenzoic acid
-
-
4-sulfamoylbenzoic acid
-
-
4-sulfosalicylic acid
-
uncompetitive inhibition of isozyme carbonic anhydrase I and competitive inhibition of isozyme carbonic anhydrase II
4-t-butylphenyl sulfamate
-
-
4-toluenesulfonamide
-
-
4-trichloromethylphenyl sulfamate
-
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
-
4-[(3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)amino]benzenesulfonamide
-
-
4-[(3-fluorophenyl)ethynyl]benzenesulfonamide
-
-
4-[(3-hydroxyphenyl)ethynyl]benzenesulfonamide
-
-
4-[(3-methoxyphenyl)ethynyl]benzenesulfonamide
-
-
4-[(4-methylphenyl)ethynyl]benzenesulfonamide
-
-
4-[(acetyloxy)amino]-N-[4-(aminosulfonyl)phenyl]benzenesulfonamide
Q16790, Q9ULX7
-
4-[(acetyloxy)amino]-N-[4-(aminosulfonyl)phenyl]benzenesulfonamide
-
-
4-[(aminooxy)sulfinyl]-2-bromoaniline
-
-
4-[(aminooxy)sulfinyl]-2-chloroaniline
-
-
4-[(aminooxy)sulfinyl]-2-fluoroaniline
-
-
4-[(aminooxy)sulfinyl]-2-iodoaniline
-
-
4-[(aminooxy)sulfinyl]aniline
-
-
4-[(aminooxy)sulfinyl]benzoic acid
-
-
4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide
Q16790, Q9ULX7
-
4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide
-
-
4-[(methylsulfonyl)amino]benzenesulfonamide
Q16790, Q9ULX7
-
4-[(methylsulfonyl)amino]benzenesulfonamide
-
-
4-[(phenylsulfonyl)amino]benzenesulfonamide
Q16790, Q9ULX7
-
4-[(phenylsulfonyl)amino]benzenesulfonamide
-
-
4-[(sulfoamino)sulfonyl]benzoic acid
-
-
4-[([(1Z)-[4-(dimethylamino)phenyl]methylidene]amino)methyl]benzenesulfonamide
-
-
4-[([[(diethyl-l5-azanylidyne)methyl]disulfanyl]amino)methyl]benzenesulfonamide
-
-
4-[2-(2-thienyl)acetamidoethyl]benzenesulfonamide
-
-
4-[2-(2-thienyl)acetamidomethyl]benzenesulfonamide
-
-
4-[2-(2-thienyl)acetamido]-3-bromobenzenesulfonamide
-
-
4-[2-(2-thienyl)acetamido]-3-chlorobenzenesulfonamide
-
-
4-[2-(2-thienyl)acetamido]-3-fluorobenzenesulfonamide
-
-
4-[2-(2-thienyl)acetamido]benzenesulfonamide
-
-
4-[2-(4-sulfamoylphenyl)ethylamino]-3-pyridinosulfonamide
-
-
4-[2-[(2-oxo-2H-chromen-3-yl)carbonyl]hydrazino]benzenesulfonamide
-
-
4-[2-[(7-methoxy-2-oxo-2H-chromen-4-yl)acetyl]hydrazino]benzenesulfonamide
-
-
4-[2-[(anilinocarbonothioyl)amino]ethyl]benzenesulfonamide
Q16790, Q9ULX7
-
4-[2-[(anilinocarbonothioyl)amino]ethyl]benzenesulfonamide
-
-
4-[2-[(anilinocarbonyl)amino]ethyl]benzenesulfonamide
Q16790, Q9ULX7
-
4-[2-[(anilinocarbonyl)amino]ethyl]benzenesulfonamide
-
-
4-[2-[([[4-(aminosulfonyl)phenyl]amino]carbonothioyl)amino]ethyl]benzenesulfonamide
Q16790, Q9ULX7
-
4-[2-[([[4-(aminosulfonyl)phenyl]amino]carbonothioyl)amino]ethyl]benzenesulfonamide
-
-
4-[3-([(1E)-[4-(dimethylamino)phenyl]methylidene]amino)propyl]benzenesulfonamide
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-alpha-D-mannopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-galactopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-alpha-D-arabinopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',5'-tri-O-benzoyl-beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy'-3',4',6'-tri-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy-beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-arabinopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-mannopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-galactopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-maltopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(hepta-O-acetyl-beta-D-maltopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(methylsulfonyl)phenyl]-3-phenyldihydrofuran-2(3H)-one
-
-
4-[cis-5-norbornene-endo-2,3-dicarboximidoethyl]-benzenesulfonamide
-
-
4-[cis-5-norbornene-endo-2,3-dicarboximidomethyl]-benzenesulfonamide
-
-
4-[cis-5-norbornene-endo-2,3-dicarboximido]-benzenesulfonamide
-
-
4-[cis-5-norbornene-endo-3-carboxy-2-carboxamidoethyl]-benzenesulfonamide
-
-
4-[cis-5-norbornene-endo-3-carboxy-2-carboxamidomethyl]-benzenesulfonamide
-
-
4-[cis-5-norbornene-endo-3-carboxy-2-carboxamido]-benzenesulfonamide
-
-
4-[N'-(1,1-dioxopyrido[4,3-e]-1,4,2-dithiazin-3-yl)hydrazino]-3-pyridinesulfonamide
-
-
4-[N'-(6-chloro-7-cyano-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazino]-3-pyridinesulfonamide
-
-
4-[N'-(6-chloro-7-methyl-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazino]-3-pyridinesulfonamide
-
-
4-[[(1Z)-(1-bromonaphthalen-2-yl)methylidene]amino]benzenesulfonamide
-
-
4-[[(2R,3R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide
-
-
4-[[(2R,5S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide
-
-
4-[[(3,4-dichlorophenyl)carbamoyl]amino]benzenesulfonamide
-
-
4-[[(3R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide
-
-
4-[[(3R,4R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide
-
-
4-[[(4R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide
-
-
4-[[(5R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide
-
-
4-[[(aminosulfonyl)amino]sulfonyl]benzoic acid
-
-
4-[[(anilinocarbonothioyl)amino]methyl]benzenesulfonamide
Q16790, Q9ULX7
-
4-[[(anilinocarbonothioyl)amino]methyl]benzenesulfonamide
-
-
4-[[(diphenylcarbamoyl)amino]methyl]benzenesulfonamide
-
-
4-[[(phenylsulfonyl)amino]methyl]benzenesulfonamide
Q16790, Q9ULX7
-
4-[[(phenylsulfonyl)amino]methyl]benzenesulfonamide
-
-
4-[[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide
-
-
4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
Q16790
-
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(2-phenylacetamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3,7,12-trioxo-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha,12alpha-dihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha,12alpha-dihydroxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha,7alpha,12alpha-triacetoxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha,7alpha,12alpha-trihydroxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha-acetoxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha-hydroxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-acetamido-1,3,4-thiadiazole-2-sulfonamide
-
-
5-acetamido-1,3,4-thiadiazole-2-sulfonamide
-
-
5-acetamido-1,3,4-thiadiazole-2-sulfonamide
-
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
-
5-chlorosalicylic acid
-
uncompetitive inhibition of isozymes carbonic anhydrase I and II
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
-
5-pentylresorcinylsulfamate
-
-
5-sulfosalicylic acid
-
competitive inhibition of isozyme carbonic anhydrase I and noncompetitive inhibition of isozyme carbonic anhydrase II
5-[(aminooxy)sulfinyl]-1,3,4-thiadiazol-2-amine
-
-
5-[(aminooxy)sulfinyl]-3-methyl-1,3,4-thiadiazol-2(3H)-imine
-
-
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[2-(2-thienyl)acetamido]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[cis-5-norbornene-endo-2,3-dicarboximido]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[cis-5-norbornene-endo-3-carboxy-2-carboxamido]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino]-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino]-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
Q8FVP0
-
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-bromophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
Q16790, Q9ULX7
-
5-[[(4-bromophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-nitrophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
Q16790, Q9ULX7
-
5-[[(4-nitrophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(pentafluorophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(phenylcarbamoyl)carbamothioyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-aminophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
6,7-dimethoxy-1-ethyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
;
6,7-dimethoxy-1-isopropyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
;
6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
;
6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
;
6,7-dimethoxy-1-propyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
;
6-((1S)-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one
-
-
6-(1-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one
-
-
6-(aminomethyl)-2H-chromen-2-one
-
-
6-(hydroxymethyl)-2-oxo-2H-chromene-3-carboxylic acid
-
-
6-(hydroxymethyl)-2H-chromen-2-one
-
-
6-acetyl-7-(benzyloxy)-2H-chromen-2-one
-
-
6-acetyl-7-adamantylethoxy-2H-chromen-2-one
-
-
6-acetyl-7-butoxy-2H-chromen-2-one
-
-
6-acetyl-7-ethoxy-2H-chromen-2-one
-
-
6-acetyl-7-hydroxy-2H-chromen-2-one
-
-
6-acetyl-7-methoxy-2H-chromen-2-one
-
-
6-acetyl-7-propoxy-2H-chromen-2-one
-
-
6-chloro-4-amino-benzene-1,3-disulfonamide
Q1CVF1, Q9WVT6
isoenzyme hpalphaCA; isoenzyme hpbetaCA
6-chloro-4-amino-benzene-1,3-disulfonamide
-
isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV
6-chloro-4-amino-benzene-1,3-disulfonamide
-
isoenzyme gammaCA
6-chloro-4-amino-benzene-1,3-disulfonamide
-
isoenzyme mCA XIII
6-deoxy-N-(4-sulfamoylphenyl)-alpha-L-mannopyranosylamine
Q8FVP0
-
6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine
-
-
6-ethoxy-1,3-benzothiazole-2-sulfonamide
-
-
6-ethoxy-2-benzo-thiazolesulfonamide
-
-
6-ethoxyzolamide
-
-
6-hydroxy-1,3-benzothiazole-2-sulfonamide
-
-
6-hydroxy-1,3-benzothiazole-2-sulfonamide
-
-
6-hydroxy-1,3-benzothiazole-2-sulfonamide
-
-
6-hydroxy-1,3-benzothiazole-2-sulfonamide
-
-
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid
-
-
6-methyl-2-oxo-2H-chromene-3-carboxylic acid
-
-
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
Q1CVF1, Q9WVT6
isoenzyme hpalphaCA; isoenzyme hpbetaCA
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
isoenzyme hCA III; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA XII; isoenzyme hCA XIV
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
isoenzyme gammaCA
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
isoenzyme mCA XIII
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide
Q1CVF1, Q9WVT6
isoenzyme hpalphaCA; isoenzyme hpbetaCA
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide
-
isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide
-
isoenzyme gammaCA
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide
-
isoenzyme mCA XIII
7-(2-phenylethoxy)-2H-chromen-2-one
-
-
7-(benzyloxy)-2H-chromen-2-one
-
-
7-alpha-hydroxydehydroepiandrosterone sulfamate
-
-
7-butoxy-2H-chromen-2-one
-
-
7-ethoxy-2H-chromen-2-one
-
-
7-ethoxy-8-propanoyl-2H-chromen-2-one
-
-
7-hydroxy-1-methoxy-3-methyl-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid
-
-
7-hydroxy-3-(hydroxymethyl)-1-methoxy-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid
-
-
7-hydroxy-6-propanoyl-2H-chromen-2-one
-
-
7-hydroxy-8-propanoyl-2H-chromen-2-one
-
-
7-methoxy-2-oxo-2H-chromene-4-carboxylic acid
-
-
7-methoxy-2H-chromen-2-one
-
-
7-methoxy-8-propanoyl-2H-chromen-2-one
-
-
7-oxodehydroepiandrosterone sulfamate
-
-
7-propoxy-2H-chromen-2-one
-
-
7alpha-hydroxyepiandrosterone sulfamate
-
-
8-acetyl-7-(benzyloxy)-2H-chromen-2-one
-
-
8-acetyl-7-butoxy-2H-chromen-2-one
-
-
8-acetyl-7-ethoxy-2H-chromen-2-one
-
-
8-acetyl-7-hydroxy-2H-chromen-2-one
-
-
8-acetyl-7-methoxy-2H-chromen-2-one
-
-
8-acetyl-7-propoxy-2H-chromen-2-one
-
-
8-methoxy-2-oxo-2H-chromene-3-carboxylic acid
-
-
8-propanoyl-7-propoxy-2H-chromen-2-one
-
-
acetaldehyde
-
modification of carbonic anhydrase II with acetaldehyde leads to decreased enzyme activity, acetaldehyde (100 mM) in the presence of NaBH3(CN) causes 23.7% reduction in CA II activity, in the absence of NaBH3(CN) the activity is only slightly reduced
acetazolamide
-
weak
acetazolamide
-
-
acetazolamide
-
carbonic anhydrase A is 100times less sensitive than carbonic anhydrase C; carbonic anhydrase A is completely inhibited at 1 mM, carbonic anhydrase C is completely inhibited at 0.01 mM
acetazolamide
-
-
acetazolamide
-
complete inhibition above 0.01 mM
acetazolamide
-
isoenzyme I
acetazolamide
-
inhibits CO2 hydration and esterase activity
acetazolamide
-
-
acetazolamide
Coccomyxa sp.
-
0.001 mM , 50% inhibition
acetazolamide
-
-
acetazolamide
Q50940
-
acetazolamide
-
100 mM, the firmly-membrane-associated activity is less sensitive to inhibition than the loosely-membrane associated enzyme
acetazolamide
-
-
acetazolamide
-
-
acetazolamide
-
-
acetazolamide
-
-
acetazolamide
-
noncompetitive reversible inhibitor
acetazolamide
-
-
acetazolamide
Q6R4A2
;
acetazolamide
P40881
IC50: 0.4 mM
acetazolamide
-
IC50: 97 nM
acetazolamide
-
increases carbonic anhydrase activity of photosystem 2 membranes at concentrations lower than 0.001 mM and suppresses this activity only at higher concentrations. Carbonic anhydrase activity of photosystem 1 membranes is suppressed
acetazolamide
Q1CVF1, Q9WVT6
isoenzyme hpalphaCA; isoenzyme hpbetaCA
acetazolamide
-
isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV
acetazolamide
-
isoenzyme gammaCA
acetazolamide
-
isoenzyme mCA XIII
acetazolamide
-
carbonic anhydrase XIII
acetazolamide
Elephas trogontherii
-
cytosolic isoenzyme; inner peripheral isoenzyme; integral isoenzyme; outer peripheral isoenzyme
acetazolamide
-
-
acetazolamide
-
i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide
acetazolamide
-
-
acetazolamide
-
i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide
acetazolamide
-
i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide
acetazolamide
-
shows effective carbonic anhydrase inhibitory activity
acetazolamide
B5SU02, -
highly inhibited by acetazolamide, i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide
acetazolamide
-
systemic carbonic anhydrase inhibitor
acetazolamide
-
promiscuous inhibitor of all isozymes except CA III
acetazolamide
-
a non-membrane-permeable carbonic anhydrase inhibitor
acetazolamide
-
uncompetitive inhibitor
acetazolamide
-
i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide
acetazolamide
-
62% residual activity at 1 mM
acetazolamide
-
effective, submicromolar inhibition
acetazolamide
-
;
acetazolamide
-
-
acetazolamide
-
-
acetazolamide
-
strong inhibition
acetic acid
-
-
acetozolamide
-
-
-
acetozolamide
-
specific inhibitor
-
acetozolamide
-
-
-
Acetylsalicylic acid
-
noncompetitive inhibition of isozymes carbonic anhydrase I and II
Ag+
-
silver inhibits competitively
Ag+
-
uncompetitive inhibition
Ag+
-
competitive, strong inhibition of carbonic anhydrase esterase activity
Ag+
-
weak inhibition
Al3+
-
competitive, very strong inhibition of carbonic anhydrase esterase activity
allylamine hydrochloride
-
-
allylsulfonamide
-
-
allylsulfonamide hydrochloride
-
-
allylsulfonyl chloride
-
-
aminobenzolamide
-
-
ArSO2-NHPO3H2
-
-
As3+
-
37.1% residual activity at 1 mM
azide
P40881
IC50: 3.4 mM
azide
-
carbonic anhydrase XIII
azide
-
weak inhibition
azide
-
best inhibitor
azide
-
shows low micromolar inhibition against CA XV
benzene-1,2-diol
-
-
benzene-1,3-diol
-
-
benzene-1,4-diol
-
-
benzenesulfonamide
-
-
benzolamide
-
-
benzolamide
-
shows effective carbonic anhydrase inhibitory activity
benzolamide
-
apical CAIV is inhibited by about 20% by 0.01 mM benzolamide
benzolamide
-
-
benzyl 2-thioxobenzo[d]oxazol-3(2H)-carboxylate
-
-
benzyl sulfamate
-
-
benzylsulfonylsulfamic acid
-
-
bicarbonate
-
shows low micromolar inhibition against CA XV
bicarbonate
-
is hypothesized to be an allosteric inhibitor of HICA
bicarbonate
-
high inhibition
bisulfate
-
weak, carbonic anhydrase XIII
bisulfite
-
-