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Literature summary for 4.2.1.1 extracted from

  • Li, Y.; Wang, H.; Tu, C.; Shiverick, K.T.; Silverman, D.N.; Frost, S.C.
    Role of hypoxia and EGF on expression, activity, localization and phosphorylation of carbonic anhydrase IX in MDA-MB-231 breast cancer cells (2011), Biochim. Biophys. Acta, 1813, 159-167.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.1

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane CAIX is the only membrane-associated carbonic anhydrase inMDA-MB-231 cells. EGF induces CAIX translocation to lipid rafts Homo sapiens 5886
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Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a zinc metalloenzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 isozyme CAIX
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Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein CAIX exists predominantly as a dimeric, high-mannose N-linked glycoprotein Homo sapiens
phosphoprotein CAIX tyrosine phosphorylation in the cytoplasmic domain. EGF induces CAIX translocation to lipid rafts but not its phosphorylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell CAIX is localized in lipid rafts Homo sapiens
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additional information CAIX is overexpressed in many types of cancer, including breast cancer, but is most frequently absent in corresponding normal tissues Homo sapiens
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Subunits

Subunits Comment Organism
dimer 2 * 54000-58000, SDS-PAGE Homo sapiens
More the active form of CAIX in the MDA-MB-231 breast cancer cell line is dimeric but that neither lipid raft localization nor phosphorylation are likely required for its dimerization or activity Homo sapiens

Synonyms

Synonyms Comment Organism
CAIX
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 Homo sapiens
carbonic anhydrase IX
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens CAIX expression is 5-7fold induced by hypoxia and is significantly associated with tumor grade and poor survival, overview up

General Information

General Information Comment Organism
additional information EGF induces CAIX translocation to lipid rafts but not its phosphorylation Homo sapiens
physiological function CAIX is a zinc metalloenzyme that catalyzes the reversible hydration of CO2. CAIX expression is strongly induced by hypoxia and is significantly associated with tumor grade and poor survival Homo sapiens