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Literature summary for 4.2.1.1 extracted from

  • Ohradanova, A.; Vullo, D.; Pastorekova, S.; Pastorek, J.; Jackson, D.J.; Woerheide, G.; Supuran, C.T.
    Cloning, characterization and sulfonamide inhibition studies of an alpha-carbonic anhydrase from the living fossil sponge Astrosclera willeyana (2012), Bioorg. Med. Chem., 20, 1403-1410.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed as a GST-fucion protein Astrosclera willeyana

Inhibitors

Inhibitors Comment Organism Structure
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
-
Astrosclera willeyana
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
Astrosclera willeyana
1,2-benzothiazol-3(2H)-one 1,1-dioxide
-
Astrosclera willeyana
1-(1,2-benzoxazol-3-yl)methanesulfonamide
-
Astrosclera willeyana
2-aminobenzenesulfonamide
-
Astrosclera willeyana
2-hydrazinylbenzenesulfonamide
-
Astrosclera willeyana
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide
-
Astrosclera willeyana
4,5-dichlorobenzene-1,3-disulfonamide
-
Astrosclera willeyana
4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide
-
Astrosclera willeyana
4-(2-aminoethyl)benzenesulfonamide
-
Astrosclera willeyana
4-(2-hydroxyethyl)benzenesulfonamide
-
Astrosclera willeyana
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
-
Astrosclera willeyana
4-(aminomethyl)benzenesulfonamide
-
Astrosclera willeyana
4-(hydroxymethyl)benzenesulfonamide
-
Astrosclera willeyana
4-amino-3,5-dibromobenzenesulfonamide
-
Astrosclera willeyana
4-amino-3,5-diiodobenzenesulfonamide
-
Astrosclera willeyana
4-amino-3-chlorobenzenesulfonamide
-
Astrosclera willeyana
4-amino-3-fluorobenzenesulfonamide
-
Astrosclera willeyana
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
Astrosclera willeyana
4-amino-6-chlorobenzene-1,3-disulfonamide
-
Astrosclera willeyana
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
Astrosclera willeyana
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
Astrosclera willeyana
4-Aminobenzenesulfonamide
-
Astrosclera willeyana
4-hydrazinylbenzenesulfonamide
-
Astrosclera willeyana
4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
-
Astrosclera willeyana
4-sulfamoylbenzoic acid
-
Astrosclera willeyana
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
Astrosclera willeyana
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
-
Astrosclera willeyana
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
Astrosclera willeyana
5-([(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino)-1,3,4-thiadiazole-2-sulfonamide
-
Astrosclera willeyana
5-([(4-aminophenyl)sulfonyl]amino)-1,3,4-thiadiazole-2-sulfonamide
-
Astrosclera willeyana
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
Astrosclera willeyana
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
Astrosclera willeyana
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
Astrosclera willeyana
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
-
Astrosclera willeyana
6-ethoxy-1,3-benzothiazole-2-sulfonamide
-
Astrosclera willeyana
6-hydroxy-1,3-benzothiazole-2-sulfonamide
-
Astrosclera willeyana
benzenesulfonamide
-
Astrosclera willeyana
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
-
Astrosclera willeyana
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
-
Astrosclera willeyana
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
-
Astrosclera willeyana
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
-
Astrosclera willeyana

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4
-
CO2 pH 7.5, 20°C Astrosclera willeyana

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33200
-
calculated from cDNA Astrosclera willeyana

Organism

Organism UniProt Comment Textmining
Astrosclera willeyana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
Astrosclera willeyana H2CO3
-
?

Synonyms

Synonyms Comment Organism
alpha-carbonic anhydrase
-
Astrosclera willeyana

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
900000
-
CO2 pH 7.5, 20°C Astrosclera willeyana

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000016
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000032
-
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000034
-
4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamide pH 7.5, 20°C Astrosclera willeyana
0.000038
-
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate pH 7.5, 20°C Astrosclera willeyana
0.000048
-
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000051
-
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide pH 7.5, 20°C Astrosclera willeyana
0.000054
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000062
-
4,5-dichlorobenzene-1,3-disulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000165
-
1-(1,2-benzoxazol-3-yl)methanesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000276
-
4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000278
-
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide pH 7.5, 20°C Astrosclera willeyana
0.00028
-
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide pH 7.5, 20°C Astrosclera willeyana
0.000326
-
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide pH 7.5, 20°C Astrosclera willeyana
0.00037
-
5-amino-1,3,4-thiadiazole-2-sulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000378
-
2-methoxy-N-[(1-methylpyrrolidin-2-yl)methyl]-5-sulfamoylbenzamide pH 7.5, 20°C Astrosclera willeyana
0.000387
-
6-ethoxy-1,3-benzothiazole-2-sulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000393
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000394
-
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide pH 7.5, 20°C Astrosclera willeyana
0.000423
-
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000517
-
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000552
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000675
-
benzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000715
-
4-(2-aminoethyl)benzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000732
-
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000751
-
1,2-benzothiazol-3(2H)-one 1,1-dioxide pH 7.5, 20°C Astrosclera willeyana
0.000792
-
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide pH 7.5, 20°C Astrosclera willeyana
0.00082
-
4-amino-6-chlorobenzene-1,3-disulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000866
-
6-hydroxy-1,3-benzothiazole-2-sulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000879
-
4-amino-3,5-diiodobenzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000884
-
4-amino-3-chlorobenzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.00089
-
4-amino-3-fluorobenzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000965
-
4-amino-3,5-dibromobenzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.000973
-
4-(aminomethyl)benzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.001215
-
4-sulfamoylbenzoic acid pH 7.5, 20°C Astrosclera willeyana
0.00138
-
4-(2-hydroxyethyl)benzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.004 26 4-(hydroxymethyl)benzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.006081
-
4-hydrazinylbenzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.0077
-
4-Aminobenzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.00775
-
2-aminobenzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.00885
-
2-hydrazinylbenzenesulfonamide pH 7.5, 20°C Astrosclera willeyana
0.04185
-
5-([(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino)-1,3,4-thiadiazole-2-sulfonamide pH 7.5, 20°C Astrosclera willeyana
0.04188
-
5-([(4-aminophenyl)sulfonyl]amino)-1,3,4-thiadiazole-2-sulfonamide pH 7.5, 20°C Astrosclera willeyana

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
110000
-
CO2 pH 7.5, 20°C Astrosclera willeyana