Application | Comment | Organism |
---|---|---|
medicine | isoform CA IX is used as a marker of tumor hypoxia and as a prognostic factor for many human cancers | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells and in insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-acetamido-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
6.9 | - |
CO2 | Escherichia coli recombinant enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | transmembrane protein | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc-containing enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CO2 + H2O | - |
Homo sapiens | H2CO3 | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | two catalytic domains of CA IX associate to form a dimer, which is stabilized by the formation of an intermolecular disulfide bond | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CA IX | - |
Homo sapiens |
carbonic anhydrase IX | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
380000 | - |
CO2 | Escherichia coli recombinant enzyme | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.025 | - |
5-acetamido-1,3,4-thiadiazole-2-sulfonamide | Escherichia coli recombinant enzyme | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression of CA IX is strongly increased in many types of tumors, such as gliomas/ependymomas, mesotheliomas, and papillary/follicular carcinomas, as well as carcinomas of the bladder, uterine cervix, kidneys, esophagus, lungs, head and neck, breast, brain, vulva, and squamous/basal cell carcinomas | up |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform CA IX is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
55000 | - |
CO2 | Escherichia coli recombinant enzyme | Homo sapiens |