Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | murine sperm possesses extracellular isozyme CA IV that is transferred to the sperm surface as the sperm pass through the epididymis, the transfer takes place in the corpus epididymidis | Mus musculus | 9986 | - |
extracellular | murine sperm possesses extracellular isozyme CA IV that is transferred to the sperm surface as the sperm pass through the epididymis, the transfer takes place in the corpus epididymidis | Mus musculus | - |
- |
intracellular | - |
Homo sapiens | 5622 | - |
plasma membrane | apical and basal plasma membrane of proximal tubuli | Mus musculus | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Mus musculus C57/BL6J | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epididymis | corpus and cauda | Mus musculus | - |
kidney | apical and basal plasma membrane of proximal tubuli | Mus musculus | - |
spermatozoon | - |
Mus musculus | - |
spermatozoon | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
CA IV | - |
Mus musculus |
carbonic anhydrase IV | - |
Mus musculus |
carbonic anhydrase IV | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | CA IV-/- mice show a 32.13% reduction in total carbonic anhydrase activity and reduced beat frequency compared to the wild-type | Mus musculus |
physiological function | role of isozyme carbonic anhydrase IV in the bicarbonate-mediated activation of sperm, overview. Sperm respond to CO2 with an increase in beat frequency, an effect that can be inhibited by ethoxyzolamide. CA IV supplies sperm with HCO3-, which is necessary for stimulation of atypical sperm adenylyl cyclase and hence early activation of spermatozoa | Mus musculus |
physiological function | role of isozyme carbonic anhydrase IV in the bicarbonate-mediated activation of sperm, overview. Sperm respond to CO2 with an increase in beat frequency, an effect that can be inhibited by ethoxyzolamide. CA IV supplies sperm with HCO3-, which is necessary for stimulation of atypical sperm adenylyl cyclase and hence early activation of spermatozoa | Homo sapiens |