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Literature summary for 4.2.1.1 extracted from

  • Syrjaenen, L.; Tolvanen, M.; Hilvo, M.; Olatubosun, A.; Innocenti, A.; Scozzafava, A.; Leppiniemi, J.; Niederhauser, B.; Hytoenen, V.P.; Gorr, T.A.; Parkkila, S.; Supuran, C.T.
    Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates (2010), BMC Biochem., 11, 28.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development Drosophila beta-CA represents a highly active mitochondrial enzyme that is a potential model enzyme for anti-parasitic drug development Drosophila melanogaster

Cloned(Commentary)

Cloned (Comment) Organism
gene DmBCA, phylogenetic analysis, expression in Spodoptera frugiperda Sf9 cells using the baculovirus transfection system Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
5-acetamido-1,3,4-thiadiazole-2-sulfonamide
-
Drosophila melanogaster
Br-
-
Drosophila melanogaster
Cl-
-
Drosophila melanogaster
ClO4- poor inhibition Drosophila melanogaster
CN-
-
Drosophila melanogaster
CNO-
-
Drosophila melanogaster
F-
-
Drosophila melanogaster
H2NSO2NH2
-
Drosophila melanogaster
H2NSO3H
-
Drosophila melanogaster
HCO3-
-
Drosophila melanogaster
HS-
-
Drosophila melanogaster
HSO3-
-
Drosophila melanogaster
I-
-
Drosophila melanogaster
N3-
-
Drosophila melanogaster
NO2-
-
Drosophila melanogaster
NO3-
-
Drosophila melanogaster
Ph-AsO3H2
-
Drosophila melanogaster
Ph-B(OH)2
-
Drosophila melanogaster
SCN-
-
Drosophila melanogaster
SO42-
-
Drosophila melanogaster
sulfamide
-
Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Drosophila melanogaster 5739
-
additional information subcellular localization study, overview Drosophila melanogaster
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Drosophila melanogaster
-
CO2 + H2O
-
r

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
gene DmBCA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2CO3
-
Drosophila melanogaster CO2 + H2O
-
r

Subunits

Subunits Comment Organism
dimer dynamic light scattering analysis and gel filtration Drosophila melanogaster

Synonyms

Synonyms Comment Organism
beta-CA
-
Drosophila melanogaster
beta-carbonic anhydrase
-
Drosophila melanogaster
CO2 hydratase
-
Drosophila melanogaster

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
20
-
assay at Drosophila melanogaster

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
950000
-
CO2 pH 8.3, 20°C Drosophila melanogaster

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
assay at Drosophila melanogaster

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000049
-
5-acetamido-1,3,4-thiadiazole-2-sulfonamide pH 8.3, 20°C Drosophila melanogaster
0.15
-
sulfamide pH 8.3, 20°C Drosophila melanogaster
0.15
-
H2NSO2NH2 pH 8.3, 20°C Drosophila melanogaster
0.67
-
CN- pH 8.3, 20°C Drosophila melanogaster
0.73
-
CNO- pH 8.3, 20°C Drosophila melanogaster
0.8
-
F- pH 8.3, 20°C Drosophila melanogaster
0.97
-
Cl- pH 8.3, 20°C Drosophila melanogaster
1.01
-
HS- pH 8.3, 20°C Drosophila melanogaster
1.04
-
Br- pH 8.3, 20°C Drosophila melanogaster
1.12
-
N3- pH 8.3, 20°C Drosophila melanogaster
1.18
-
I- pH 8.3, 20°C Drosophila melanogaster
1.28
-
SCN- pH 8.3, 20°C Drosophila melanogaster
1.29
-
HSO3- pH 8.3, 20°C Drosophila melanogaster
1.36
-
SO42- pH 8.3, 20°C Drosophila melanogaster
2.45
-
H2NSO3H pH 8.3, 20°C Drosophila melanogaster
22.4
-
Ph-B(OH)2 pH 8.3, 20°C Drosophila melanogaster
26.9
-
HCO3- pH 8.3, 20°C Drosophila melanogaster
28.6
-
NO2- pH 8.3, 20°C Drosophila melanogaster
32.6
-
Ph-AsO3H2 pH 8.3, 20°C Drosophila melanogaster
43.7
-
NO3- pH 8.3, 20°C Drosophila melanogaster
200
-
ClO4- above, pH 8.3, 20°C Drosophila melanogaster

General Information

General Information Comment Organism
evolution phylogenetic analysis of beta-class carbonic anhydrases in invertebrates, overview Drosophila melanogaster

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
110000
-
CO2 pH 8.3, 20°C Drosophila melanogaster