Application | Comment | Organism |
---|---|---|
medicine | design of novel antitumor properties, mainly for hypoxic tumors that overexpress CA IX | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
CA I and CA II cDNA expressed in Escherichia coli BL21 (DE3), cDNA hCA IX PCR amplified | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2:3,4-di-O-isopropylidene-alpha-D-galactopyranose 6-sulfamate | - |
Homo sapiens | |
1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose 3-sulfamate | - |
Homo sapiens | |
2,4,6-trichlorophenyl sulfamate | - |
Homo sapiens | |
2-naphthyl sulfamate | - |
Homo sapiens | |
2-naphthylsulfamate | - |
Homo sapiens | |
3-methylphenylsulfamate | - |
Homo sapiens | |
4-acetylamidophenyl sulfamate | - |
Homo sapiens | |
4-bromophenyl sulfamate | - |
Homo sapiens | |
4-chlorophenyl sulfamate | best CA IX inhibitor | Homo sapiens | |
4-cyanophenyl sulfamate | - |
Homo sapiens | |
4-iodophenyl sulfamate | - |
Homo sapiens | |
4-methoxyphenyl sulfamate | - |
Homo sapiens | |
4-methylphenyl sulfamate | - |
Homo sapiens | |
4-nitrophenyl sulfamate | - |
Homo sapiens | |
4-phenoxyphenyl sulfamate | - |
Homo sapiens | |
4-phenylphenyl sulfamate | - |
Homo sapiens | |
4-t-butylphenyl sulfamate | - |
Homo sapiens | |
4-trichloromethylphenyl sulfamate | - |
Homo sapiens | |
5-pentylresorcinylsulfamate | - |
Homo sapiens | |
acetazolamide | - |
Homo sapiens | |
dehydroepiandrosterone sulfamate | - |
Homo sapiens | |
EMATE | - |
Homo sapiens | |
estradiol 17 beta-sulfamate | - |
Homo sapiens | |
estradiol 3,17 beta-disulfamate | CA II inhibitor | Homo sapiens | |
estrone sulfamate | - |
Homo sapiens | |
ethoxzolamide | - |
Homo sapiens | |
methazolamide | - |
Homo sapiens | |
n-octyl sulfamate | - |
Homo sapiens | |
pentachlorophenyl sulfamate | - |
Homo sapiens | |
pentafluorophenyl sulfamate | - |
Homo sapiens | |
phenylsulfamate | best CA I inhibitor | Homo sapiens | |
sulfamate | - |
Homo sapiens | |
sulfamic acid | - |
Homo sapiens | |
topiramate | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
membrane | transmembrane isozyme IX | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | Homo sapiens | - |
CO2 + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
H2CO3 | - |
Homo sapiens | CO2 + H2O | - |
r |
Synonyms | Comment | Organism |
---|---|---|
CA | - |
Homo sapiens |
CA I | - |
Homo sapiens |
CA II | - |
Homo sapiens |
CA IX | - |
Homo sapiens |
carbonic anhydrase | - |
Homo sapiens |
carbonic anhydrase isozyme I | - |
Homo sapiens |
carbonic anhydrase isozyme II | - |
Homo sapiens |
carbonic anhydrase isozyme IX | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000013 | - |
phenylsulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.0000019 | - |
3-methylphenyl sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.0000021 | - |
phenylsulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.0000027 | - |
n-octyl sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.0000029 | - |
4-t-butylphenyl sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.0000035 | - |
n-octylsulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.0000038 | - |
3-methylphenylsulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.0000038 | - |
4-iodophenyl sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.0000046 | - |
4-chlorophenyl sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000005 | - |
topiramate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000005 | - |
estradiol 3,17beta-disulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000006 | - |
estradiol 3,17beta-disulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.0000073 | - |
4-bromophenyl sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000008 | - |
ethoxzolamide | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.0000095 | - |
4-iodophenyl sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.00001 | - |
estrone sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000012 | - |
acetazolamide | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000013 | - |
estradiol 17beta-sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000014 | - |
methazolamide | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000015 | - |
estradiol 17beta-sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000015 | - |
1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose 3-sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000018 | - |
4-acetylamidophenyl sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000018 | - |
4-chlorophenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000019 | - |
4-bromophenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000023 | - |
sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000023 | - |
4-iodophenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000025 | - |
ethoxzolamide | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000025 | - |
acetazolamide | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000025 | - |
n-octylsulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000026 | - |
sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000027 | - |
dehydroepiandrosterone sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000027 | - |
methazolamide | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000028 | - |
sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000029 | - |
1,2:3,4-di-O-isopropylidene-alpha-D-galactopyranose 6-sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.00003 | - |
estrone sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000031 | - |
dehydroepiandrosterone sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000032 | - |
1,2:3,4-di-O-isopropylidene-alpha-D-galactopyranose 6-sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000032 | - |
estradiol 17beta-sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000033 | - |
4-methoxyphenyl sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000033 | - |
4-t-butylphenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000034 | - |
ethoxzolamide | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000034 | - |
4-methoxyphenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000036 | - |
4-nitrophenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000037 | - |
4-acetylamidophenyl sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000037 | - |
estrone sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000037 | - |
2,4,6-trichlorophenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000039 | - |
1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose 3-sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000039 | - |
pentachlorophenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.00004 | - |
4-nitrophenylsulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.00004 | - |
2-naphthyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000041 | - |
4-cyanophenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000043 | - |
4-t-butylphenyl sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000043 | - |
5-pentylresorcinylsulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000045 | - |
4-acetylamidophenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000047 | - |
pentafluorophenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.00005 | - |
4-biphenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000051 | - |
4-phenoxyphenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000054 | - |
dehydroepiandrosterone sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000054 | - |
4-trifluoromethylphenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000058 | - |
estradiol 3,17beta-disulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000059 | - |
4-methylphenyl sulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000063 | - |
2-naphthyl sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000063 | - |
phenylsulfamate | pH 7.4, 25°C, hCA IX | Homo sapiens | |
0.000076 | - |
5-pentylresorcinylsulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000095 | - |
4-biphenyl sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000098 | - |
p-phenoxyphenylsulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000103 | - |
2-naphthylsulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000105 | - |
5-pentylresorcinyl sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000113 | - |
4-biphenyl sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000113 | - |
pentafluorophenyl sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000115 | - |
4-phenoxyphenyl sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000125 | - |
pentachlorophenylsulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000138 | - |
2,4,6-trichlorophenyl sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000138 | - |
4-trifluoromethylphenyl sulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.000149 | - |
4-cyanophenylsulfamate | pH 7.4, 25°C, hCA II | Homo sapiens | |
0.00025 | - |
topiramate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000278 | - |
1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose 3-sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000315 | - |
1,2:3,4-di-O-isopropylidene-alpha-D-galactopyranose 6-sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000369 | - |
p-trifluoromethylphenylsulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000415 | - |
pentafluorophenyl sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000432 | - |
pentachlorophenyl sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.000454 | - |
2,4,6-trichlorophenyl sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.00048 | - |
4-cyanophenyl sulfamate | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.00078 | - |
methazolamide | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.0009 | - |
acetazolamide | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.021 | - |
sulfamic acid | pH 7.4, 25°C, hCA I | Homo sapiens | |
0.097 | - |
sulfamic acid | pH 7.4, 25°C, hCA II | Homo sapiens |