Literature summary for 4.2.1.1 extracted from

Tu, C.; Qian, M.; An, H.; Wadhwa, N.R.; Duda, D.; Yoshioka, C.; Pathak, Y.; McKenna, R.; Laipis, P.J.; Silverman, D.N.
Kinetic analysis of multiple proton shulttles in the active site of human carbonic anhydrase (2002), J. Biol. Chem., 277, 38870-38876.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
site-specific mutant Y7H, crystals produced by the hanging drop method, space group P2(1) with unit cell dimensions a : 42.9 A, b: 41.6 A, c : 73.0 A	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
F198L	site-specific mutagenesis, HCA III	Homo sapiens
H64A	site-specific mutagenesis, HCA II	Homo sapiens
K64H	site-specific mutagenesis, HCA III	Homo sapiens
K64H/F198L	site-specific mutagenesis, HCA III	Homo sapiens
K64H/R67H	site-specific mutagenesis, HCA III	Homo sapiens
R67H	site-specific mutagenesis, HCA III	Homo sapiens
Y7H	site-specific mutagenesis, HCA II	Homo sapiens
Y7H	site-specific mutagenesis, HCA III	Homo sapiens
Y7H/F198L	site-specific mutagenesis, HCA III	Homo sapiens
Y7H/H64A	site-specific mutagenesisHCA II	Homo sapiens
Y7H/K64H	site-specific mutagenesis, HCA III	Homo sapiens
Y7H/K64H/F198L	site-specific mutagenesis, HCA III	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
H2CO3	Homo sapiens	-	CO2 + H2O	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00918	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
H2CO3	-	Homo sapiens	CO2 + H2O	-	r

Synonyms

Synonyms	Comment	Organism
carbonic anhydrase	-	Homo sapiens
HCA II	-	Homo sapiens
human carbonic anhydrase II	-	Homo sapiens
human carbonic anhydrase III	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	-	-	Homo sapiens

pH Range

pH Minimum	pH Maximum	Comment	Organism
5	9	-	Homo sapiens

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Release 2023.1 (January 2023)