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Literature summary for 4.2.1.1 extracted from

  • Xiao, Z.; Duan, R.; Cui, W.; Zhang, Y.; Zhang, S.; Chen, F.; Zhang, Y.; Liu, J.; Zhang, D.; Meng, Y.; Wang, L.; Wang, H.
    Synthesis and evaluation of new carbonic anhydrase inhibitors (2011), Bioorg. Med. Chem., 19, 3221-3228.
    View publication on PubMed
Search for more literature for 4.2.1.1

Cloned(Commentary)

Cloned (Comment) Organism
isozyme hCAII, expression in Escherichia coli strain BL21(DE3) from the plasmids pET-28b/hCA II Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-(benzenesulfonamido-N-benzyl)-5-[N,Ndibenzylsulfonamido]-l,3,4-thiadiazole
-
 Homo sapiens
2-(p-toluenesulfonamido)-l,3,4-thiadiazole-5-sulfonamide
-
 Homo sapiens
2-benzene-sulfonamido-l,3,4-thiadiazole-5-sulfonamide
-
 Homo sapiens
2-[(p-toluenesulfonamido)-N-methyl]-5-[N,N-dimethylsulfonamide]-l,3,4-thiadiazole
-
 Homo sapiens
2-[benzenesulfonamido-N-(n-propyl)]-l,3,4-thiadiazole-5-sulfonamide
-
 Homo sapiens
5-[(2-phenylethyl)(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-[(benzylsulfonyl)(2,4-dichlorobenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-[(benzylsulfonyl)(2-methylpropyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-[(benzylsulfonyl)(3,4,5-trimethoxybenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-[(benzylsulfonyl)(4-chlorobenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-[(benzylsulfonyl)(4-methoxybenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-[(benzylsulfonyl)(butyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-[(benzylsulfonyl)(dodecyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-[(benzylsulfonyl)(pentyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-[(benzylsulfonyl)(propan-2-yl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-[benzyl(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-[ethyl(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-[methyl(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{(2,4-dichlorobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{(4-bromobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{(4-chlorobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{(4-fluorobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{(4-methoxybenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{(4-methylbenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{(benzylsulfonyl)[2-(4-bromophenyl)ethyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{benzyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{butyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{dodecyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{ethyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{methyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{[(4-methylphenyl)sulfonyl](2-methylpropyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{[(4-methylphenyl)sulfonyl](2-phenylethyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{[(4-methylphenyl)sulfonyl](3,4,5-trimethoxybenzyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{[(4-methylphenyl)sulfonyl](pentyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{[(4-methylphenyl)sulfonyl](propan-2-yl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{[(4-methylphenyl)sulfonyl](propyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{[2-(4-bromophenyl)ethyl][(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{[3-(2-methoxyphenyl)propyl][(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
acetazolamide
-
 Homo sapiens
additional information synthesis of 2-[(p-toluenesulfonamido)-N-yl]-l,3,4-thiadiazole-5-sulfonamide inhibitors, inhibitory potencies versus isozymes CAII, docking study, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
carbonic anhydrase
-
 Homo sapiens
carbonic anhydrase II
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function isoyzme CAII is associated with the acute mountain sickness, a common disease at high altitude Homo sapiens