Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3)pLysS cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
crystals of carbonic anhydrase II and carbonic anhydrase IX mimic are grown at room temperature using the hanging drop vapour diffusion method | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A65S | the mutation can cause variations in binding affinity of small molecule inhibitors | Homo sapiens |
N67Q | the mutation can cause variations in binding affinity of small molecule inhibitors | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetazolamide | - |
Homo sapiens | |
benzolamide | - |
Homo sapiens | |
chlorzolamide | potent inhibitor | Homo sapiens | |
ethoxzolamide | - |
Homo sapiens | |
methazolamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00918 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CO2 + H2O | - |
Homo sapiens | H2CO3 | - |
r |
Synonyms | Comment | Organism |
---|---|---|
CA II | - |
Homo sapiens |
CA IX | - |
Homo sapiens |
carbonic anhydrase II | - |
Homo sapiens |
carbonic anhydrase IX | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000001 | - |
ethoxzolamide | Ki less than 0.000001 mM wild type carbonic anhydrase II | Homo sapiens | |
0.000001 | - |
chlorzolamide | wild type carbonic anhydrase IX | Homo sapiens | |
0.000002 | - |
chlorzolamide | wild type carbonic anhydrase II | Homo sapiens | |
0.000003 | - |
acetazolamide | wild type carbonic anhydrase IX | Homo sapiens | |
0.000007 | - |
benzolamide | wild type carbonic anhydrase II | Homo sapiens | |
0.000009 | - |
methazolamide | wild type carbonic anhydrase IX | Homo sapiens | |
0.000009 | - |
benzolamide | wild type carbonic anhydrase IX | Homo sapiens | |
0.0000101 | - |
acetazolamide | wild type carbonic anhydrase II | Homo sapiens | |
0.0000118 | - |
methazolamide | wild type carbonic anhydrase II | Homo sapiens |