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Literature summary for 4.2.1.1 extracted from

  • Innocenti, A.; Hilvo, M.; Scozzafava, A.; Parkkila, S.; Supuran, C.T.
    Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols (2008), Bioorg. Med. Chem. Lett., 18, 3593-3596.
    View publication on PubMed
Search for more literature for 4.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
2,5-difluorophenol
-
 Mus musculus
3,5-difluorophenol
-
 Mus musculus
4-Aminophenol
-
 Mus musculus
4-hydroxybenzoic acid
-
 Mus musculus
4-Hydroxybenzonitrile
-
 Mus musculus
acetazolamide
-
 Mus musculus
benzene-1,2-diol
-
 Mus musculus
benzene-1,3-diol
-
 Mus musculus
benzene-1,4-diol
-
 Mus musculus
clioquinol
-
 Mus musculus
paracetamol
-
 Mus musculus
phenol
-
 Mus musculus
salicylic acid
-
 Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
14.2
-
 CO2 at pH 7.5 and 20°C Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
 Mus musculus H2CO3
-
 r

Synonyms

Synonyms Comment Organism
Ca XV
-
 Mus musculus
carbonic anhydrase XV isoform Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
470000
-
 CO2 at pH 7.5 and 20°C Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000072
-
 acetazolamide at pH 7.5 and 20°C Mus musculus
0.00233
-
 clioquinol at pH 7.5 and 20°C Mus musculus
0.0072
-
 salicylic acid at pH 7.5 and 20°C Mus musculus
0.00923
-
 paracetamol at pH 7.5 and 20°C Mus musculus
0.00932
-
 4-hydroxybenzoic acid at pH 7.5 and 20°C Mus musculus
0.0102
-
 benzene-1,2-diol at pH 7.5 and 20°C Mus musculus
0.0105
-
 phenol at pH 7.5 and 20°C Mus musculus
0.0106
-
 benzene-1,4-diol at pH 7.5 and 20°C Mus musculus
0.0113
-
 3,5-difluorophenol at pH 7.5 and 20°C Mus musculus
0.212
-
 2,5-difluorophenol at pH 7.5 and 20°C Mus musculus
0.335
-
 4-Aminophenol at pH 7.5 and 20°C Mus musculus
0.385
-
 benzene-1,3-diol at pH 7.5 and 20°C Mus musculus
0.434
-
 4-Hydroxybenzonitrile at pH 7.5 and 20°C Mus musculus