Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-4-methoxy-4-oxobut-2-enoic acid | - |
Homo sapiens | |
(2E)-but-2-enedioic acid | - |
Homo sapiens | |
(2R)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid | - |
Homo sapiens | |
(2S)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid | - |
Homo sapiens | |
(3-chloro-4-hydroxyphenyl)acetic acid | - |
Homo sapiens | |
(3-chlorophenyl)acetic acid | - |
Homo sapiens | |
(4-hydroxyphenyl)acetic acid | - |
Homo sapiens | |
(5Z)-2-amino-5-(3,4-dihydroxybenzylidene)-3,5-dihydro-4H-imidazol-4-one | - |
Homo sapiens | |
(5Z)-2-amino-5-(4-hydroxy-3-methoxybenzylidene)-3,5-dihydro-4H-imidazol-4-one | - |
Homo sapiens | |
2-(3-chloro-4-hydroxyphenyl)-N-(2-methoxyethyl)acetamide | - |
Homo sapiens | |
2-(3-chloro-4-hydroxyphenyl)-N-(2-phenylethyl)acetamide | - |
Homo sapiens | |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide | - |
Homo sapiens | |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3-methoxyphenyl)ethyl]acetamide | - |
Homo sapiens | |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide | - |
Homo sapiens | |
2-(3-chloro-4-hydroxyphenyl)acetamide | - |
Homo sapiens | |
2-(4-hydroxyphenyl)acetamide | - |
Homo sapiens | |
4,4'-[(1R,2R,3S,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol) | - |
Homo sapiens | |
4,4'-[(1R,2S,3R,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol) | - |
Homo sapiens | |
4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol) | - |
Homo sapiens | |
4-(2-hydroxyethyl)phenol | - |
Homo sapiens | |
7-hydroxy-1-methoxy-3-methyl-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid | - |
Homo sapiens | |
7-hydroxy-3-(hydroxymethyl)-1-methoxy-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid | - |
Homo sapiens | |
acetazolamide | - |
Homo sapiens | |
methyl (3-chloro-4-hydroxyphenyl)acetate | - |
Homo sapiens | |
N-benzyl-2-(3-chloro-4-hydroxyphenyl)acetamide | - |
Homo sapiens | |
N-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide | - |
Homo sapiens | |
N-tert-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide | - |
Homo sapiens | |
phenol | - |
Homo sapiens | |
sulfanilamide | - |
Homo sapiens | |
topiramate | - |
Homo sapiens | |
zonisamide | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isoforms CA I and CA II | Homo sapiens | 5829 | - |
mitochondrion | isoforms CA VA and CA VB | Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CO2 + H2O | Homo sapiens | - |
H2CO3 | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CO2 + H2O | - |
Homo sapiens | H2CO3 | - |
r |
Synonyms | Comment | Organism |
---|---|---|
CA I | cytosolic isoform | Homo sapiens |
CA II | cytosolic isoform | Homo sapiens |
CA VA | mitochondrial isoform | Homo sapiens |
CA VB | mitochondrial isoform | Homo sapiens |
carbonic anhydrase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000018 | - |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide | isoform CA II | Homo sapiens | |
0.000069 | - |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide | isoform CA VB | Homo sapiens | |
0.000069 | - |
4,4'-[(1R,2R,3S,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol) | isoform CA VB | Homo sapiens | |
0.00007 | - |
(5Z)-2-amino-5-(4-hydroxy-3-methoxybenzylidene)-3,5-dihydro-4H-imidazol-4-one | isoform CA VB | Homo sapiens | |
0.000071 | - |
4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol) | isoform CA VB | Homo sapiens | |
0.000076 | - |
(5Z)-2-amino-5-(3,4-dihydroxybenzylidene)-3,5-dihydro-4H-imidazol-4-one | isoform CA VB | Homo sapiens | |
0.000079 | - |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide | isoform CA VB | Homo sapiens | |
0.000079 | - |
4,4'-[(1R,2S,3R,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol) | isoform CA VB | Homo sapiens | |
0.000081 | - |
2-(4-hydroxyphenyl)acetamide | isoform CA VB | Homo sapiens | |
0.000081 | - |
N-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA VB | Homo sapiens | |
0.000084 | - |
2-(3-chloro-4-hydroxyphenyl)-N-(2-methoxyethyl)acetamide | isoform CA VB | Homo sapiens | |
0.000085 | - |
4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol) | isoform CA VA | Homo sapiens | |
0.000085 | - |
(3-chlorophenyl)acetic acid | isoform CA VB | Homo sapiens | |
0.000085 | - |
N-benzyl-2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA VB | Homo sapiens | |
0.000087 | - |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3-methoxyphenyl)ethyl]acetamide | isoform CA VB | Homo sapiens | |
0.000089 | - |
N-tert-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA VB | Homo sapiens | |
0.00009 | - |
(2E)-but-2-enedioic acid | isoform CA VB | Homo sapiens | |
0.000091 | - |
4,4'-[(1R,2R,3S,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol) | isoform CA VA | Homo sapiens | |
0.000091 | - |
2-(3-chloro-4-hydroxyphenyl)-N-(2-phenylethyl)acetamide | isoform CA VB | Homo sapiens | |
0.000092 | - |
2-(4-hydroxyphenyl)acetamide | isoform CA VA | Homo sapiens | |
0.000093 | - |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide | isoform CA VA | Homo sapiens | |
0.000093 | - |
7-hydroxy-1-methoxy-3-methyl-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid | isoform CA VA | Homo sapiens | |
0.000094 | - |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide | isoform CA VA | Homo sapiens | |
0.000094 | - |
7-hydroxy-3-(hydroxymethyl)-1-methoxy-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid | isoform CA VA | Homo sapiens | |
0.000095 | - |
(2R)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid | isoform CA VA | Homo sapiens | |
0.000096 | - |
(3-chlorophenyl)acetic acid | isoform CA VA | Homo sapiens | |
0.000096 | - |
N-benzyl-2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA VA | Homo sapiens | |
0.000097 | - |
(2E)-but-2-enedioic acid | isoform CA VA | Homo sapiens | |
0.000098 | - |
4,4'-[(1R,2S,3R,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol) | isoform CA VA | Homo sapiens | |
0.000098 | - |
(2E)-4-methoxy-4-oxobut-2-enoic acid | isoform CA VB | Homo sapiens | |
0.000099 | - |
(4-hydroxyphenyl)acetic acid | isoform CA VA | Homo sapiens | |
0.000099 | - |
(5Z)-2-amino-5-(4-hydroxy-3-methoxybenzylidene)-3,5-dihydro-4H-imidazol-4-one | isoform CA VA | Homo sapiens | |
0.0001 | - |
(3-chloro-4-hydroxyphenyl)acetic acid | isoform CA VA | Homo sapiens | |
0.000101 | - |
(5Z)-2-amino-5-(3,4-dihydroxybenzylidene)-3,5-dihydro-4H-imidazol-4-one | isoform CA VA | Homo sapiens | |
0.000101 | - |
2-(3-chloro-4-hydroxyphenyl)-N-(2-phenylethyl)acetamide | isoform CA VA | Homo sapiens | |
0.000101 | - |
4-(2-hydroxyethyl)phenol | isoform CA VA | Homo sapiens | |
0.000102 | - |
2-(3-chloro-4-hydroxyphenyl)-N-(2-methoxyethyl)acetamide | isoform CA VA | Homo sapiens | |
0.000102 | - |
7-hydroxy-3-(hydroxymethyl)-1-methoxy-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid | isoform CA VB | Homo sapiens | |
0.000102 | - |
(2S)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid | isoform CA VB | Homo sapiens | |
0.000103 | - |
(2E)-4-methoxy-4-oxobut-2-enoic acid | isoform CA VA | Homo sapiens | |
0.000103 | - |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3-methoxyphenyl)ethyl]acetamide | isoform CA VA | Homo sapiens | |
0.000103 | - |
7-hydroxy-1-methoxy-3-methyl-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid | isoform CA VB | Homo sapiens | |
0.000105 | - |
N-tert-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA VA | Homo sapiens | |
0.000105 | - |
4-(2-hydroxyethyl)phenol | isoform CA VB | Homo sapiens | |
0.000106 | - |
2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA VB | Homo sapiens | |
0.000107 | - |
(4-hydroxyphenyl)acetic acid | isoform CA VB | Homo sapiens | |
0.000108 | - |
N-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA VA | Homo sapiens | |
0.000108 | - |
(2S)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid | isoform CA VA | Homo sapiens | |
0.000109 | - |
methyl (3-chloro-4-hydroxyphenyl)acetate | isoform CA VA | Homo sapiens | |
0.00011 | - |
2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA VA | Homo sapiens | |
0.000114 | - |
(2R)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid | isoform CA VB | Homo sapiens | |
0.000118 | - |
(3-chloro-4-hydroxyphenyl)acetic acid | isoform CA VB | Homo sapiens | |
0.000125 | - |
methyl (3-chloro-4-hydroxyphenyl)acetate | isoform CA VB | Homo sapiens | |
0.0007 | - |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide | isoform CA I | Homo sapiens | |
0.0075 | - |
(2E)-4-methoxy-4-oxobut-2-enoic acid | isoform CA II | Homo sapiens | |
0.008 | - |
(2S)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid | isoform CA II | Homo sapiens | |
0.0083 | - |
(2R)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid | isoform CA II | Homo sapiens | |
0.0084 | - |
7-hydroxy-1-methoxy-3-methyl-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid | isoform CA II | Homo sapiens | |
0.0086 | - |
(3-chloro-4-hydroxyphenyl)acetic acid | isoform CA II | Homo sapiens | |
0.0087 | - |
4-(2-hydroxyethyl)phenol | isoform CA II | Homo sapiens | |
0.0092 | - |
7-hydroxy-3-(hydroxymethyl)-1-methoxy-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid | isoform CA II | Homo sapiens | |
0.0094 | - |
N-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA II | Homo sapiens | |
0.0096 | - |
2-(3-chloro-4-hydroxyphenyl)-N-(2-phenylethyl)acetamide | isoform CA I | Homo sapiens | |
0.0096 | - |
(5Z)-2-amino-5-(4-hydroxy-3-methoxybenzylidene)-3,5-dihydro-4H-imidazol-4-one | isoform CA II | Homo sapiens | |
0.0098 | - |
2-(3-chloro-4-hydroxyphenyl)-N-(2-phenylethyl)acetamide | isoform CA II | Homo sapiens | |
0.0101 | - |
(3-chlorophenyl)acetic acid | isoform CA II | Homo sapiens | |
0.0104 | - |
2-(3-chloro-4-hydroxyphenyl)-N-(2-methoxyethyl)acetamide | isoform CA II | Homo sapiens | |
0.0105 | - |
(5Z)-2-amino-5-(4-hydroxy-3-methoxybenzylidene)-3,5-dihydro-4H-imidazol-4-one | isoform CA I | Homo sapiens | |
0.0105 | - |
N-benzyl-2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA I | Homo sapiens | |
0.0105 | - |
(2E)-but-2-enedioic acid | isoform CA II | Homo sapiens | |
0.0107 | - |
N-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA I | Homo sapiens | |
0.0107 | - |
methyl (3-chloro-4-hydroxyphenyl)acetate | isoform CA II | Homo sapiens | |
0.0108 | - |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3-methoxyphenyl)ethyl]acetamide | isoform CA II | Homo sapiens | |
0.0108 | - |
N-tert-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA II | Homo sapiens | |
0.0112 | - |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3-methoxyphenyl)ethyl]acetamide | isoform CA I | Homo sapiens | |
0.0112 | - |
2-(4-hydroxyphenyl)acetamide | isoform CA II | Homo sapiens | |
0.0114 | - |
N-tert-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA I | Homo sapiens | |
0.0114 | - |
N-benzyl-2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA II | Homo sapiens | |
0.0115 | - |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide | isoform CA II | Homo sapiens | |
0.0117 | - |
4,4'-[(1R,2R,3S,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol) | isoform CA II | Homo sapiens | |
0.0119 | - |
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide | isoform CA I | Homo sapiens | |
0.0121 | - |
4,4'-[(1R,2S,3R,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol) | isoform CA II | Homo sapiens | |
0.0131 | - |
(5Z)-2-amino-5-(3,4-dihydroxybenzylidene)-3,5-dihydro-4H-imidazol-4-one | isoform CA II | Homo sapiens | |
0.103 | - |
(4-hydroxyphenyl)acetic acid | isoform CA II | Homo sapiens | |
0.131 | - |
2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA II | Homo sapiens | |
0.158 | - |
2-(3-chloro-4-hydroxyphenyl)-N-(2-methoxyethyl)acetamide | isoform CA I | Homo sapiens | |
0.201 | - |
7-hydroxy-1-methoxy-3-methyl-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid | isoform CA I | Homo sapiens | |
0.23 | - |
4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol) | isoform CA II | Homo sapiens | |
0.231 | - |
(2S)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid | isoform CA I | Homo sapiens | |
0.237 | - |
2-(3-chloro-4-hydroxyphenyl)acetamide | isoform CA I | Homo sapiens | |
0.239 | - |
(2R)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid | isoform CA I | Homo sapiens | |
0.244 | - |
(3-chlorophenyl)acetic acid | isoform CA I | Homo sapiens | |
0.265 | - |
(3-chloro-4-hydroxyphenyl)acetic acid | isoform CA I | Homo sapiens | |
0.284 | - |
(2E)-4-methoxy-4-oxobut-2-enoic acid | isoform CA I | Homo sapiens | |
0.307 | - |
4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol) | isoform CA I | Homo sapiens | |
0.309 | - |
(4-hydroxyphenyl)acetic acid | isoform CA I | Homo sapiens | |
0.309 | - |
2-(4-hydroxyphenyl)acetamide | isoform CA I | Homo sapiens | |
0.354 | - |
4,4'-[(1R,2S,3R,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol) | isoform CA I | Homo sapiens | |
0.355 | - |
(5Z)-2-amino-5-(3,4-dihydroxybenzylidene)-3,5-dihydro-4H-imidazol-4-one | isoform CA I | Homo sapiens | |
0.368 | - |
4,4'-[(1R,2R,3S,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol) | isoform CA I | Homo sapiens | |
0.369 | - |
methyl (3-chloro-4-hydroxyphenyl)acetate | isoform CA I | Homo sapiens | |
0.374 | - |
7-hydroxy-3-(hydroxymethyl)-1-methoxy-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid | isoform CA I | Homo sapiens | |
0.395 | - |
(2E)-but-2-enedioic acid | isoform CA I | Homo sapiens | |
0.43 | - |
4-(2-hydroxyethyl)phenol | isoform CA I | Homo sapiens |