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Literature summary for 4.2.1.1 extracted from

  • Vullo, D.; Nishimori, I.; Scozzafava, A.; Koehler, S.; Winum, J.Y.; Supuran, C.T.
    Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides (2010), Bioorg. Med. Chem. Lett., 20, 2178-2182.
    View publication on PubMed
Search for more literature for 4.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
4-[(3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)amino]benzenesulfonamide
-
 Brucella suis
4-[[(2R,3R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide
-
 Brucella suis
4-[[(2R,5S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide
-
 Brucella suis
4-[[(3R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide
-
 Brucella suis
4-[[(3R,4R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide
-
 Brucella suis
4-[[(4R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide
-
 Brucella suis
4-[[(5R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide
-
 Brucella suis
4-[[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide
-
 Brucella suis
acetazolamide i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide Brucella suis
sulfanilamide quite weak CA 1 inhibitor Brucella suis

Organism

Organism UniProt Comment Textmining
Brucella suis A0A0H3GB68
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
 Brucella suis H2CO3
-
 r

Synonyms

Synonyms Comment Organism
beta-carbonic anhydrase
-
 Brucella suis
CA 1
-
 Brucella suis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
640000
-
 CO2 at 20°C, pH 8.3 in 20 mM Tris-HCl buffer and 20 mM NaCl Brucella suis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000089
-
 4-[[(4R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide at 20°C, pH 8.3 in 20 mM Tris-HCl buffer and 20 mM NaCl Brucella suis
0.0000092
-
 4-[[(5R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide at 20°C, pH 8.3 in 20 mM Tris-HCl buffer and 20 mM NaCl Brucella suis
0.000019
-
 4-[[(2R,3R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide at 20°C, pH 8.3 in 20 mM Tris-HCl buffer and 20 mM NaCl Brucella suis
0.000028
-
 4-[[(2R,5S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide at 20°C, pH 8.3 in 20 mM Tris-HCl buffer and 20 mM NaCl Brucella suis
0.000063
-
 acetazolamide at 20°C, pH 8.3 in 20 mM Tris-HCl buffer and 20 mM NaCl Brucella suis
0.000065
-
 4-[[(3R,4R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide at 20°C, pH 8.3 in 20 mM Tris-HCl buffer and 20 mM NaCl Brucella suis
0.000067
-
 4-[(3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)amino]benzenesulfonamide at 20°C, pH 8.3 in 20 mM Tris-HCl buffer and 20 mM NaCl Brucella suis
0.000103
-
 4-[[(3R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide at 20°C, pH 8.3 in 20 mM Tris-HCl buffer and 20 mM NaCl Brucella suis
0.00011
-
 4-[[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]amino]benzenesulfonamide at 20°C, pH 8.3 in 20 mM Tris-HCl buffer and 20 mM NaCl Brucella suis
0.0025
-
 sulfanilamide at 20°C, pH 8.3 in 20 mM Tris-HCl buffer and 20 mM NaCl Brucella suis

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
39000
-
 CO2
-
 Brucella suis