Literature summary for 4.2.1.1 extracted from

Isik, S.; Guler, O.O.; Kockar, F.; Aydin, M.; Arslan, O.; Supuran, C.T.
Saccharomyces cerevisiae beta-carbonic anhydrase: inhibition and activation studies (2010), Curr. Pharm. Des., 16, 3327-3336.

Search for more literature for 4.2.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
L-adrenaline	-	Saccharomyces cerevisiae
additional information	L-adrenaline and some piperazines incorporating aminoethyl moieties were the most effective scCA activators	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
4-(2-amino-pyrimidin-4-yl)-benzenesulfonamide	-	Saccharomyces cerevisiae
bromide	-	Saccharomyces cerevisiae
Iodide	-	Saccharomyces cerevisiae
additional information	bromide, iodide and sulfamide, are the best anion inhibitors, with Ki values of 0.0087-0.0108 mM. Benzenesulfonamides substituted in 2-, 4- and 3,4-positions with amino, alkyl, halogeno and hydroxyalkyl moieties have Ki values in the range of 0.000976-0.01845 mM. Better inhibition with Ki values in the range of 154-654 nM is observed for benzenesulfonamides incorporating aminoalkyl/carboxyalkyl moieties or halogenosulfanilamides, benzene-1,3-disulfonamides, simple heterocyclic sulfonamides and sulfanilyl-sulfonamides. The clinically used sulfonamides/sulfamates, e.g. acetazolamide, ethoxzolamide, methazolamide, dorzolamide, topiramate, celecoxib, generally show effective scCA inhibitory activity, with Ki values in the range of 82.6-133 nM, overview	Saccharomyces cerevisiae
sulfamide	-	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
H2CO3	Saccharomyces cerevisiae	-	CO2 + H2O	-	r

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	gene Nce103	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
H2CO3	-	Saccharomyces cerevisiae	CO2 + H2O	-	r

Synonyms

Synonyms	Comment	Organism
beta-carbonic anhydrase	-	Saccharomyces cerevisiae
scCA	-	Saccharomyces cerevisiae

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
940000	-	CO2	pH not specified in the publication, temperature not specified in the publication	Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000151	-	4-(2-amino-pyrimidin-4-yl)-benzenesulfonamide	pH not specified in the publication, temperature not specified in the publication	Saccharomyces cerevisiae

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
98000	-	CO2	pH not specified in the publication, temperature not specified in the publication	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)