Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-adrenaline | - |
Saccharomyces cerevisiae | |
additional information | L-adrenaline and some piperazines incorporating aminoethyl moieties were the most effective scCA activators | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(2-amino-pyrimidin-4-yl)-benzenesulfonamide | - |
Saccharomyces cerevisiae | |
bromide | - |
Saccharomyces cerevisiae | |
Iodide | - |
Saccharomyces cerevisiae | |
additional information | bromide, iodide and sulfamide, are the best anion inhibitors, with Ki values of 0.0087-0.0108 mM. Benzenesulfonamides substituted in 2-, 4- and 3,4-positions with amino, alkyl, halogeno and hydroxyalkyl moieties have Ki values in the range of 0.000976-0.01845 mM. Better inhibition with Ki values in the range of 154-654 nM is observed for benzenesulfonamides incorporating aminoalkyl/carboxyalkyl moieties or halogenosulfanilamides, benzene-1,3-disulfonamides, simple heterocyclic sulfonamides and sulfanilyl-sulfonamides. The clinically used sulfonamides/sulfamates, e.g. acetazolamide, ethoxzolamide, methazolamide, dorzolamide, topiramate, celecoxib, generally show effective scCA inhibitory activity, with Ki values in the range of 82.6-133 nM, overview | Saccharomyces cerevisiae | |
sulfamide | - |
Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | Saccharomyces cerevisiae | - |
CO2 + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
gene Nce103 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | - |
Saccharomyces cerevisiae | CO2 + H2O | - |
r |
Synonyms | Comment | Organism |
---|---|---|
beta-carbonic anhydrase | - |
Saccharomyces cerevisiae |
scCA | - |
Saccharomyces cerevisiae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
940000 | - |
CO2 | pH not specified in the publication, temperature not specified in the publication | Saccharomyces cerevisiae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000151 | - |
4-(2-amino-pyrimidin-4-yl)-benzenesulfonamide | pH not specified in the publication, temperature not specified in the publication | Saccharomyces cerevisiae |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
98000 | - |
CO2 | pH not specified in the publication, temperature not specified in the publication | Saccharomyces cerevisiae |