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Literature summary for 4.2.1.1 extracted from
- Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity (2013), Bioorg. Med. Chem., 21, 1522-1525.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-bromo-benzenesulfonamide | - |
Ovis aries |  |
| 4-(2-aminoethyl) benzenesulfonamide | - |
Ovis aries | |
| 4-amino-6-chlorobenzene-1,3-disulfonamide | - |
Ovis aries | |
| 4-methylbenzenesulfonamide | - |
Ovis aries | |
| benzenesulfonamide | - |
Ovis aries | |
| mafenide | - |
Ovis aries | |
| naphthalene-2-sulfonamide | - |
Ovis aries | |
| saccharin | - |
Ovis aries | |
| sulfanilamide | - |
Ovis aries | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01787 | - |
4-nitrophenyl acetate | Vmax: 0.168 micromol/min, pH 8.5, 35°C | Ovis aries | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 29000 | - |
SDS-PAGE | Ovis aries |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| affinity chromatography | Ovis aries |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Storage Stability
| Storage Stability | Organism |
|---|---|
| 20 mM Tris-HCl (pH 8.5) buffer, 14 days, 97 activity maintained | Ovis aries |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl acetate + H2O | - |
Ovis aries | 4-nitrophenol + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hCAII | - |
Ovis aries |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 35 | - |
- |
Ovis aries |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Ovis aries |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001348 | - |
4-methylbenzenesulfonamide | pH 8.5, 35°C | Ovis aries | |
| 0.002586 | - |
naphthalene-2-sulfonamide | pH 8.5, 35°C | Ovis aries | |
| 0.0038 | - |
mafenide | pH 8.5, 35°C | Ovis aries | |
| 0.0045 | - |
4-amino-6-chlorobenzene-1,3-disulfonamide | pH 8.5, 35°C | Ovis aries | |
| 0.005874 | - |
2-bromo-benzenesulfonamide | pH 8.5, 35°C | Ovis aries | |
| 0.008664 | - |
benzenesulfonamide | pH 8.5, 35°C | Ovis aries | |
| 0.0096 | - |
4-(2-aminoethyl) benzenesulfonamide | pH 8.5, 35°C | Ovis aries | |
| 0.0315 | - |
saccharin | pH 8.5, 35°C | Ovis aries | |
| 0.06931 | - |
sulfanilamide | pH 8.5, 35°C | Ovis aries | |
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