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Literature summary for 4.2.1.1 extracted from

  • Tu, C.; Tripp, B.C.; Ferry, J.G.; Silverman, D.N.
    Bicarbonate as a proton donor in catalysis by Zn(II)- and Co(II)-containing carbonic anhydrases (2001), J. Am. Chem. Soc., 123, 5861-5866.
    View publication on PubMed
Search for more literature for 4.2.1.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens
expressed in Escherichia coli Methanosarcina thermophila

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
H64A site-specific mutant Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ Co2+ containing Homo sapiens
Zn2+ Zn2+ containing Homo sapiens
Zn2+ Zn2+ containing Methanosarcina thermophila

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Homo sapiens
-
 CO2 + H2O
-
 r
H2CO3 Methanosarcina thermophila
-
 CO2 + H2O
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Methanosarcina thermophila
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens
recombinant enzyme Methanosarcina thermophila

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2CO3
-
 Homo sapiens CO2 + H2O
-
 r
H2CO3
-
 Methanosarcina thermophila CO2 + H2O
-
 r

Synonyms

Synonyms Comment Organism
Cam
-
 Methanosarcina thermophila
carbonic anhydrase
-
 Methanosarcina thermophila
human carbonic anhydrase II
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
-
 Methanosarcina thermophila
7.8 8.5 mutant H64A Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7.2 9
-
 Methanosarcina thermophila