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Literature summary for 4.2.1.1 extracted from

  • Nishita, T.; Tomita, Y.; Imanari, T.; Ichihara, N.; Orito, K.; Arishima, K.
    Biochemical and developmental characterization of carbonic anhydrase II from chicken erythrocytes (2011), Acta Vet. Scand., 53, 16.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
(3-chlorophenyl)(2-thioxo-1H-benzo[d]imidazol-1-yl)methanone
-
 Gallus gallus
(E)-3-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)prop-2-en-1-one 36% inhibition Gallus gallus
1,3-benzoxazole-2(3H)-thione
-
 Gallus gallus
1,3-diacetyl-1H-benzo[d]imidazol-2(3H)-one 10% inhibition Gallus gallus
1,3-diacetylbenzimidazole-2-thione
-
 Gallus gallus
1,3-dihydro-2H-benzimidazole-2-thione
-
 Gallus gallus
1-(2-thioxo-1H-benzo[d]imidazol-1-yl)-3-phenylpropan-1-one
-
 Gallus gallus
1-(2-thioxo-1H-benzo[d]imidazol-1-yl)ethanone
-
 Gallus gallus
1-(2-thioxo-1H-benzo[d]imidazol-1-yl)hexan-1-one
-
 Gallus gallus
1-(2-thioxo-1H-benzo[d]imidazol-1-yl)propan-1one
-
 Gallus gallus
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)decan-1-one
-
 Gallus gallus
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone
-
 Gallus gallus
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)hexadecan-1-one
-
 Gallus gallus
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)hexan-1-one
-
 Gallus gallus
1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one
-
 Gallus gallus
1-(2-Tthioxo-1H-benzo[d]imidazol-1-yl)butan-1-one
-
 Gallus gallus
1-(3-acetyl-1,2-dihydro-2-thioxobenzo[d]imidazol-1-yl)hexan-1-one
-
 Gallus gallus
1-(3-ethyl-1,2-dihydro-2-thioxobenzo[d]imidazole-1-yl)ethanone
-
 Gallus gallus
1-ethyl-1H-benzo[d]imidazole-2(3H)-thione 28% inhibition Gallus gallus
2-phenoxy-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone
-
 Gallus gallus
2-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone
-
 Gallus gallus
3-acetylbenzo[d]oxazol-2(3H)-one
-
 Gallus gallus
3-cyclohexyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one
-
 Gallus gallus
3-ethylbenzo[d]oxazole-2(3H)-thione 17% inhibition Gallus gallus
3-hexanoylbenzo[d]oxazol-2(3H)-one
-
 Gallus gallus
3-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one
-
 Gallus gallus
4-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)butan-1-one
-
 Gallus gallus
benzyl 2-thioxobenzo[d]oxazol-3(2H)-carboxylate
-
 Gallus gallus
methyl 2-sulfanylbenzo[d]oxazole-5-carboxylate 27% inhibition Gallus gallus
methyl-3-(3-phenylpropanoyl)-2,3-dihydro-2-thioxobenzo[d]oxazole-5-carboxylate
-
 Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
 i.e. WL-chicken, male and female chicken, isozyme CA-II
-
Gallus gallus
-
 male and female chicken, isozyme CA-II
-
Gallus gallus Araucana-chicken
-
 i.e. WL-chicken, male and female chicken, isozyme CA-II
-
Gallus gallus Araucana-chicken
-
 male and female chicken, isozyme CA-II
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from erythrocytes by gel filtration and electrofocusing Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte developmental expression profile of CA-II in erythrocytes of male and female chicken, age-related changes of CA-II levels in erythrocytes, overview Gallus gallus
-
additional information the concentration of CA-II in the erythrocytes of WL-chicken is much higher than that in erythrocytes from Araucana-chicken Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 isozyme CA-II from erythrocytes is 7.8fold more active than CA-I Gallus gallus

Synonyms

Synonyms Comment Organism
CA-II
-
 Gallus gallus
carbonic anhydrase II
-
 Gallus gallus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
 pH 7.4, 37°C Gallus gallus 1,3-diacetyl-1H-benzo[d]imidazol-2(3H)-one
0.005
-
 pH 7.4, 37°C Gallus gallus 1,3-diacetylbenzimidazole-2-thione
0.012
-
 pH 7.4, 37°C Gallus gallus 1-(3-acetyl-1,2-dihydro-2-thioxobenzo[d]imidazol-1-yl)hexan-1-one
0.016
-
 pH 7.4, 37°C Gallus gallus 1-(2-thioxo-1H-benzo[d]imidazol-1-yl)hexan-1-one
0.017
-
 pH 7.4, 37°C Gallus gallus 1-(2-thioxo-1H-benzo[d]imidazol-1-yl)ethanone
0.017
-
 pH 7.4, 37°C Gallus gallus 1-(2-thioxobenzo[d]oxazol-3(2H)-yl)hexadecan-1-one
0.019
-
 pH 7.4, 37°C Gallus gallus 1-(3-ethyl-1,2-dihydro-2-thioxobenzo[d]imidazole-1-yl)ethanone
0.019
-
 pH 7.4, 37°C Gallus gallus 4-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)butan-1-one
0.02
-
 pH 7.4, 37°C Gallus gallus 3-cyclohexyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one
0.02
-
 pH 7.4, 37°C Gallus gallus 1-(2-Tthioxo-1H-benzo[d]imidazol-1-yl)butan-1-one
0.021
-
 pH 7.4, 37°C Gallus gallus methyl-3-(3-phenylpropanoyl)-2,3-dihydro-2-thioxobenzo[d]oxazole-5-carboxylate
0.024
-
 pH 7.4, 37°C Gallus gallus 3-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one
0.025
-
 pH 7.4, 37°C Gallus gallus 1-(2-thioxobenzo[d]oxazol-3(2H)-yl)decan-1-one
0.026
-
 pH 7.4, 37°C Gallus gallus 1-(2-thioxo-1H-benzo[d]imidazol-1-yl)propan-1one
0.029
-
 pH 7.4, 37°C Gallus gallus 1-(2-thioxo-1H-benzo[d]imidazol-1-yl)-3-phenylpropan-1-one
0.029
-
 pH 7.4, 37°C Gallus gallus 1-(2-thioxobenzo[d]oxazol-3(2H)-yl)hexan-1-one
0.042
-
 pH 7.4, 37°C Gallus gallus 1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone
0.048
-
 pH 7.4, 37°C Gallus gallus 1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one
0.062
-
 pH 7.4, 37°C Gallus gallus 2-phenoxy-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone
0.069
-
 pH 7.4, 37°C Gallus gallus 2-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone
0.07
-
 pH 7.4, 37°C Gallus gallus (3-chlorophenyl)(2-thioxo-1H-benzo[d]imidazol-1-yl)methanone
0.556
-
 pH 7.4, 37°C Gallus gallus benzyl 2-thioxobenzo[d]oxazol-3(2H)-carboxylate

General Information

General Information Comment Organism
physiological function the enzyme from chicken has an important role in eggshell formation Gallus gallus