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Literature summary for 4.2.1.1 extracted from

  • Guezel, O.; Innocenti, A.; Scozzafava, A.; Salman, A.; Supuran, C.T.
    Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors (2009), Bioorg. Med. Chem. Lett., 19, 3170-3173.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-(2-phenylacetamido)-3-bromobenzenesulfonamide
-
Homo sapiens
4-(2-phenylacetamido)-3-chlorobenzenesulfonamide
-
Homo sapiens
4-(2-phenylacetamido)-3-fluorobenzenesulfonamide
-
Homo sapiens
4-(2-phenylacetamido)benzenesulfonamide
-
Homo sapiens
4-(2-phenylacetamidoethyl)benzenesulfonamide
-
Homo sapiens
4-(2-phenylacetamidomethyl)benzenesulfonamide
-
Homo sapiens
4-(2-pyridin-2-ylacetamido)benzenesulfonamide
-
Homo sapiens
4-(2-pyridin-4-ylacetamido)benzenesulfonamide
-
Homo sapiens
4-(2-pyridin-4-ylacetamidoethyl)benzenesulfonamide
-
Homo sapiens
4-[2-(2-thienyl)acetamidoethyl]benzenesulfonamide
-
Homo sapiens
4-[2-(2-thienyl)acetamidomethyl]benzenesulfonamide
-
Homo sapiens
4-[2-(2-thienyl)acetamido]-3-bromobenzenesulfonamide
-
Homo sapiens
4-[2-(2-thienyl)acetamido]-3-chlorobenzenesulfonamide
-
Homo sapiens
4-[2-(2-thienyl)acetamido]-3-fluorobenzenesulfonamide
-
Homo sapiens
4-[2-(2-thienyl)acetamido]benzenesulfonamide
-
Homo sapiens
5-(2-phenylacetamido)-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
5-[2-(2-thienyl)acetamido]-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
acetazolamide
-
Homo sapiens
ethoxzolamide
-
Homo sapiens
topiramate
-
Homo sapiens
zonisamide
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CO2 + H2O Homo sapiens
-
H2CO3
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
Homo sapiens H2CO3
-
r

Synonyms

Synonyms Comment Organism
CA I isoform Homo sapiens
CA II isoform Homo sapiens
CA VII isoform Homo sapiens
carbonic anhydrase
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000008
-
ethoxzolamide isoform CA VII Homo sapiens
0.0000009
-
topiramate isoform CA VII Homo sapiens
0.0000025
-
acetazolamide isoform CA VII Homo sapiens
0.0000047
-
4-(2-phenylacetamido)benzenesulfonamide isoform CA VII Homo sapiens
0.0000053
-
4-(2-phenylacetamido)-3-bromobenzenesulfonamide isoform CA VII Homo sapiens
0.0000054
-
4-(2-phenylacetamido)-3-fluorobenzenesulfonamide isoform CA VII Homo sapiens
0.0000055
-
4-(2-phenylacetamidoethyl)benzenesulfonamide isoform CA VII Homo sapiens
0.0000061
-
5-(2-phenylacetamido)-1,3,4-thiadiazole-2-sulfonamide isoform CA VII Homo sapiens
0.0000062
-
4-[2-(2-thienyl)acetamido]benzenesulfonamide isoform CA VII Homo sapiens
0.0000068
-
4-(2-phenylacetamidomethyl)benzenesulfonamide isoform CA VII Homo sapiens
0.0000069
-
4-[2-(2-thienyl)acetamido]-3-chlorobenzenesulfonamide isoform CA VII Homo sapiens
0.0000069
-
5-[2-(2-thienyl)acetamido]-1,3,4-thiadiazole-2-sulfonamide isoform CA VII Homo sapiens
0.0000069
-
4-(2-phenylacetamido)-3-chlorobenzenesulfonamide isoform CA VII Homo sapiens
0.000007
-
4-[2-(2-thienyl)acetamido]-3-fluorobenzenesulfonamide isoform CA VII Homo sapiens
0.0000071
-
4-[2-(2-thienyl)acetamidomethyl]benzenesulfonamide isoform CA VII Homo sapiens
0.0000072
-
4-[2-(2-thienyl)acetamido]-3-bromobenzenesulfonamide isoform CA VII Homo sapiens
0.0000076
-
4-[2-(2-thienyl)acetamidoethyl]benzenesulfonamide isoform CA VII Homo sapiens
0.0000077
-
4-(2-pyridin-2-ylacetamido)benzenesulfonamide isoform CA VII Homo sapiens
0.0000079
-
4-(2-pyridin-4-ylacetamido)benzenesulfonamide isoform CA VII Homo sapiens
0.0000085
-
4-(2-pyridin-4-ylacetamidoethyl)benzenesulfonamide isoform CA VII Homo sapiens
0.000117
-
zonisamide isoform CA VII Homo sapiens