Information on EC 3.4.14.5 - dipeptidyl-peptidase IV

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
3.4.14.5
-
RECOMMENDED NAME
GeneOntology No.
dipeptidyl-peptidase IV
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
-
-
-
-
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
active site structure and accessibility
P22346, Q9CE11
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
serine protease, catalytic triad Ser630, Asp708, His740, active site architecture
-
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
exopeptidase that cleaves dipeptides from the N-terminus of oligo- and polypeptides with the penultimate residue being proline or alanine
-
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
active site structure modeling and reaction mechanism
-
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
enzyme prefers Ala in P1 position, reduced activity is observed with Ser, Gly, or Val at the P1 position, modeling of reaction mechanism and substrate binding at the catalytic site
-
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
proline specific serine protease
-
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
serine protease
-
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
cleaves dipeptides containing proline or alanine or one of several other amino acids at the penultimate position from the amino termini of substrates, contains a Ser-His-Asp catalytic triad, active site structure, the Glu-Glu motif is necessary for amino dipeptide selection
-
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
reaction mechanism
-
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
conserved residues Ser624, Asp702, and His734 form a catalytic triad and are involved in the catalytic reaction, Ser593 is likely to be the catalytic serine of the serine protease
O66223
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
specific for hydrolysis of peptide bond on the carboxylic side of proline residues which are penultimate from the amino terminus
-
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
enzyme is an ectopeptidase
-
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
enzyme is a serine protease, catalytic and substrate binding mechanism, active site structure, catalytic triad Ser630, Asp708, His740
P27487
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
serine protease
-
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
catalytic domain structure, active site and substrate recognition study
-
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
prefers Pro or Ala at position P1, substrate recognition involves the negatively charged active site residues E205 and E206, reaction mechanism, active site structure and substrate binding
-
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
active site structure, containing the catalytic triad Ser630, Asp708, and His740, is located in a large cavity at the interface of the 2 domains, substrate binding and catalytic mechanism, serine exopeptidase
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of peptide bond
-
-
exopeptidase, N-terminus, dipeptide
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
(GLP1)-degrading enzyme
-
-
ACT3
-
-
-
-
ADA binding protein
P27487
-
ADA-binding protein
-
-
ADABP
-
-
-
-
adenosine deaminase binding protein
-
-
adenosine deaminase binding protein
P27487
-
Adenosine deaminase complexing protein
-
-
-
-
adenosine deaminase-binding protein
-
-
amino acyl-prolyl dipeptidyl aminopeptidase
-
-
-
-
aminopeptidase, glycylproline
-
-
-
-
Bile canaliculus domain-specific membrane glycoprotein
-
-
-
-
CD26
P27487
-
CD26
P27487
enzyme is identical with adenosine deaminase binding protein, CD26
CD26
P14740
dipeptidyl-peptidase IV is identical with the adenosine deaminase binding protein CD26 on lymphocytes
CD26 peptidase
-
-
CD26/dipeptidyl peptidase
-
-
CD26/DP IV
-
-
DAP IV
Q6F3I7
-
DAP IV
Q6F3I7
-
-
DapB
Q96VT7
-
dipeptidyl aminopeptidase IV
-
-
-
-
dipeptidyl aminopeptidase IV
-
-
dipeptidyl aminopeptidase IV
-
-
dipeptidyl aminopeptidase IV
O66223
-
dipeptidyl dipeptidase IV
-
-
dipeptidyl peptidase 4
-
-
dipeptidyl peptidase 4
-
-
dipeptidyl peptidase 8
-
-
dipeptidyl peptidase 9
-
-
dipeptidyl peptidase IV
-
-
dipeptidyl peptidase IV
-
-
dipeptidyl peptidase IV
-
-
dipeptidyl peptidase IV
-
-
dipeptidyl peptidase IV
-
-
dipeptidyl peptidase IV
P27487
-
dipeptidyl peptidase IV
-
-
dipeptidyl peptidase IV
-
-
dipeptidyl peptidase IV
-
-
dipeptidyl peptidase IV
-
-
dipeptidyl peptidase IV
P14740
-
dipeptidyl peptidase IV
Rattus norvegicus Wistar
-
-
-
dipeptidyl peptidase IV
-
-
dipeptidyl peptidase IV
-
-
dipeptidyl peptidase IV
-
-
dipeptidyl peptidase IV
P22411
-
dipeptidyl peptidase-4
-
-
dipeptidyl peptidase-4
-
-
dipeptidyl peptidase-4
-
-
dipeptidyl peptidase-4
-
-
dipeptidyl peptidase-4
-
-
dipeptidyl peptidase-IV
-
-
dipeptidyl peptidase-IV
Mus musculus NOD/LtJ
-
-
-
dipeptidyl peptidase-IV
-
-
dipeptidyl peptidase-IV
-
-
dipeptidyl peptiddase IV
-
-
dipeptidyl-aminopeptidase IV
-
-
-
-
dipeptidyl-peptidase 4
-
-
dipeptidyl-peptidase IV (CD26)
-
-
-
-
dipeptidyl-peptide hydrolase
-
-
-
-
dipeptidylpeptidase 4a
Q75S83
-
dipeptidylpeptidase 4b
Q75S82
-
dipeptidylpeptidase IV
-
-
dipeptidylpeptidase IV
-
-
dipeptidylpeptidase IV/CD26
-
-
dipeptidylpeptidase-IV
-
-
DP IV
P22411
-
DP-IV
-
-
DPIV
-
-
DPIV
-
-
DPP IV
-
-
DPP IV
-
DPP IV has the preference for X-Pro over X-Ala, where X is any amino acid other than L-proline
DPP IV
-
-
DPP IV
P14740
-
DPP IV/CD26
-
-
-
-
DPP-4
-
-
DPP-IV
P27487
-
DPP-IV
Mus musculus NOD/LtJ
-
-
-
DPP8
-
DPP8 is a prolyl dipeptidases, cleaving the peptide bond after the penultimate proline residue
DPP9
-
DPP9 is a prolyl dipeptidases, cleaving the peptide bond after the penultimate proline residue
DPPIV
-
-
DPPIV
P27487
-
DPPIV
-
-
DPPIV
P14740
-
DppIVA
-
isozyme
DppIVB
-
isozyme
glucagon-like peptide 1-degrading enzyme
-
-
Gly-Pro-naphthylamidase
-
-
-
-
glycoprotein GP110
-
-
-
-
glycylproline aminopeptidase
-
-
-
-
glycylproline-dipeptidyl-aminopeptidase
-
-
-
-
glycylprolyl aminopeptidase
-
-
-
-
glycylprolyl dipeptidylaminopeptidase
-
-
-
-
GP110 glycoprotein
-
-
-
-
leukocyte antigen CD26
-
-
-
-
omega enzyme
-
-
omega gene product
-
one of five putative DPP IV genes
Pep X
-
-
-
-
peptidase, dipeptidyl, IV
-
-
-
-
PepX
Q9CE11
-
postproline dipeptidyl aminopeptidase IV
-
-
-
-
prolyl-dipeptidyl-aminopeptidase
-
-
sipeptidyl peptidase IV
-
-
T cell triggering molecule Tp103
-
-
-
-
T-cell activation antigen CD26
-
-
-
-
THAM
-
-
-
-
Thymocyte-activating molecule
-
-
-
-
TP103
-
-
-
-
type IV dipeptidyl aminopeptidase
Q96VT7
-
WC10
-
-
-
-
X-PDAP
-
-
-
-
X-PDAP
Q9CE11
-
X-prolyl dipeptidyl aminopeptidase
-
-
-
-
X-prolyl dipeptidyl aminopeptidase
Q9CE11
-
Xaa-Pro-dipeptidyl-aminopeptidase
-
-
-
-
lymphocyte, antigen CD26
-
-
-
-
additional information
-
enzyme belongs to the group of dipeptidylpeptidase-IV activity and/or structure homologues, i.e. DASH
additional information
-
enzyme belongs to the prolyl oligopeptidase POP family
additional information
-
enzyme belongs to the protease clan SC
additional information
P27487
the enzyme is not identical with attractin
additional information
Q9CE11
enzyme belongs to the SC clan that includes 38 families of peptidases, and is the prototype of the S15 family
additional information
-
enzyme belongs to the protease clan SC
CAS REGISTRY NUMBER
COMMENTARY
54249-88-6
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
American crocodile
-
-
Manually annotated by BRENDA team
dipeptidylpeptidase 4a
SwissProt
Manually annotated by BRENDA team
dipeptidylpeptidase 4b
SwissProt
Manually annotated by BRENDA team
multifunctional enzyme
SwissProt
Manually annotated by BRENDA team
patients with type 2 diabetes
-
-
Manually annotated by BRENDA team
patients with type 2 diabetes mellitus
-
-
Manually annotated by BRENDA team
recombinant
SwissProt
Manually annotated by BRENDA team
recombinant
-
-
Manually annotated by BRENDA team
recombinant enzyme
SwissProt
Manually annotated by BRENDA team
recombinant wild-type enzyme
-
-
Manually annotated by BRENDA team
T-cell enzyme
SwissProt
Manually annotated by BRENDA team
Lactobacillus helveticus CNRZ 32
CNRZ 32
-
-
Manually annotated by BRENDA team
Lactobacillus helveticus LHE-511
LHE-511
-
-
Manually annotated by BRENDA team
spp. lactis NCDO 763
-
-
Manually annotated by BRENDA team
ssp. cremoris
SwissProt
Manually annotated by BRENDA team
ssp. lactis
-
-
Manually annotated by BRENDA team
subsp. casei LLG
-
-
Manually annotated by BRENDA team
subsp. cremonis nTR
-
-
Manually annotated by BRENDA team
subsp. cremonis, P8-2-47
-
-
Manually annotated by BRENDA team
high fat-fed mice
-
-
Manually annotated by BRENDA team
male C57BL/6NCrj mice
-
-
Manually annotated by BRENDA team
strain NOD/LtJ
-
-
Manually annotated by BRENDA team
wild-type mice and enzyme-deficient mutant strain C57BI/6 mice
-
-
Manually annotated by BRENDA team
Mus musculus NOD/LtJ
strain NOD/LtJ
-
-
Manually annotated by BRENDA team
no activity in Cricetulus griseus
chinese hamster, ovary cells
-
-
Manually annotated by BRENDA team
periodontal pathogen, strain W38, gene dpp
O66223
SwissProt
Manually annotated by BRENDA team
strain WO24
SwissProt
Manually annotated by BRENDA team
strain WO24
SwissProt
Manually annotated by BRENDA team
male Fisher F344 rat
-
-
Manually annotated by BRENDA team
male Wistar
-
-
Manually annotated by BRENDA team
male Wistar rats
-
-
Manually annotated by BRENDA team
male Zucker diabetic rats
-
-
Manually annotated by BRENDA team
Sprague-Dawley rats
-
-
Manually annotated by BRENDA team
Wistar rat
-
-
Manually annotated by BRENDA team
Wistar rats
-
-
Manually annotated by BRENDA team
Zucker rats
-
-
Manually annotated by BRENDA team
Rattus norvegicus Wistar
Wistar
-
-
Manually annotated by BRENDA team
a heat-resistant enzyme from protoplast lysate and a thermosensitive tonoplast-bound enzyme
-
-
Manually annotated by BRENDA team
ATCC 9811
-
-
Manually annotated by BRENDA team
Streptococcus salivarius HHT
HHT
-
-
Manually annotated by BRENDA team
serotype 2
-
-
Manually annotated by BRENDA team
Streptococcus thermophilus ACA-DC 4
ACA-DC 4
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
malfunction
-
DPP-IV knockout mice have no major differences in the leukocytes populations in spleen, thymus and blood as compared to their wild type controls
malfunction
-
DPP4-deficient rats are resistant to developing diabetes, while susceptible to dyslipidaemia and reduction of glomerular filtration rate by streptozotocin
physiological function
-
DPPIV overexpression may lead to the reduced tumorigenicity and restoration of sensitivity to paclitaxel in epithelial ovarian carcinoma cells in vitro and in vivo
physiological function
-
dipeptidyl peptidase IV regulates T lymphocyte activation
physiological function
-
DPP IV contributes to virulence of streptococcal toxic shock syndrome-causing Streptococcus suis serotype 2
physiological function
-
DPP4 activation may be responsible for hyperglycaemia, lipid metabolism and preservation of renal function
physiological function
-
DPPIV promotes apoptosis in neuroblastoma cells through caspase activation and decreased Akt phosphorylation, and inhibits stromal-derived factor 1-mediated in vitro cell migration and angiogenic potential. DPPIV plays a potential role in inhibiting neuroblastoma growth and progression
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(Ala-Pro)2-rhodamine R110 + H2O
Ala-Pro + rhodamine R110
show the reaction diagram
-
-
-
?
Ala-4-nitroanilide + H2O
Ala + 4-nitroaniline
show the reaction diagram
-
low activity
-
-
?
Ala-4-nitroanilide + H2O
Ala + 4-nitroaniline
show the reaction diagram
-
1% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
show the reaction diagram
-
-
-
?
Ala-Ala-4-nitroanilide + H2O
Ala-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
Ala-Ala-4-nitroanilide + H2O
Ala-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Ala-Ala-4-nitroanilide + H2O
Ala-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Ala-Ala-4-nitroanilide + H2O
Ala-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Ala-Ala-4-nitroanilide + H2O
Ala-Ala + 4-nitroaniline
show the reaction diagram
-
2% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Ala-Ala-4-nitroanilide + H2O
Ala-Ala + 4-nitroaniline
show the reaction diagram
-
20% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Ala-Ala-4-nitroanilide + H2O
Ala-Ala + 4-nitroaniline
show the reaction diagram
Q673U2, -
36% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Ala-Ala-4-nitroanilide + H2O
Ala-Ala + 4-nitroaniline
show the reaction diagram
Lactobacillus helveticus LHE-511
-
-
-
-
?
Ala-Ala-4-nitroanilide + H2O
Ala-Ala + 4-nitroaniline
show the reaction diagram
Lactococcus lactis nTR
-
-
-
-
?
Ala-Ala-4-nitroanilide + H2O
Ala-Ala + 4-nitroaniline
show the reaction diagram
Lactobacillus helveticus CNRZ 32
-
2% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Ala-Ala-Ala + H2O
Ala-Ala + Ala
show the reaction diagram
-
-
-
?
Ala-Ala-Ala + H2O
Ala-Ala + Ala
show the reaction diagram
-
-
-
?
Ala-Ala-Ala + H2O
Ala-Ala + Ala
show the reaction diagram
-
L-Ala-L-Ala-L-Ala
-
-
?
Ala-Ala-Ala-Ala-Ala + H2O
Ala-Ala + Ala-Ala-Ala
show the reaction diagram
-
-
with traces of Ala4 and Ala after 2.5 h incubation
?
Ala-Ala-Pro-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
-
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
-
high activity
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
Q673U2, -
80% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
Lactobacillus helveticus LHE-511
-
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
Lactococcus lactis NCDO 763
-
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
Lactococcus lactis P8-2-47
-
-
-
-
?
Ala-Pro-7-amido-4-methylcoumarin + H2O
Ala-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Ala-Pro-7-amido-4-methylcoumarin + H2O
Ala-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Ala-Pro-7-amido-4-methylcoumarin + H2O
Ala-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Ala-Pro-7-amido-4-methylcoumarin + H2O
Ala-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Ala-Pro-7-amido-4-methylcoumarin + H2O
Ala-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Ala-Pro-7-amido-4-trifluoromethyl coumarin + H2O
Ala-Pro + 7-amino-4-trifluoromethyl coumarin
show the reaction diagram
-
-
-
?
Ala-Pro-7-amido-4-trifluoromethylcoumarin + H2O
Ala-Pro + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
-
?
Ala-Pro-Gly + H2O
Ala-Pro + Gly
show the reaction diagram
-
-
-
-
?
Ala-Pro-Gly + H2O
Ala-Pro + Gly
show the reaction diagram
-
-
-
?
Ala-Pro-Gly + H2O
Ala-Pro + Gly
show the reaction diagram
-
11% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Ala-Pro-Gly + H2O
Ala-Pro + Gly
show the reaction diagram
-
72% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Ala-Pro-Gly + H2O
Ala-Pro + Gly
show the reaction diagram
Lactobacillus helveticus CNRZ 32
-
11% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Ala-Pro-p-nitroanilide + H2O
Ala-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
alpha1-microglobulin + H2O
?
show the reaction diagram
-
-
-
-
?
aprotinin + H2O
?
show the reaction diagram
-
-
-
-
?
Arg-4-nitroanilide + H2O
Arg + 4-nitroaniline
show the reaction diagram
Streptococcus thermophilus, Streptococcus thermophilus ACA-DC 4
-
2% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
-
48.6% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
-
55% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
-
130% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
Q673U2, -
42% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
Streptococcus salivarius HHT
-
48.6% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
Streptococcus thermophilus ACA-DC 4
-
55% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
Lactobacillus helveticus LHE-511
-
-
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
Lactococcus lactis NCDO 763
-
-
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
Lactococcus lactis nTR
-
-
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
Lactobacillus helveticus CNRZ 32
-
130% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Arg-Pro-7-amido-4-methylcoumarin + H2O
Arg-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
high activity
-
?
Arg-Pro-Lys-Pro + H2O
?
show the reaction diagram
-
-
-
-
?
Arg-Pro-Lys-Pro-Gln-Gln-Phe + H2O
?
show the reaction diagram
-
-
-
-
?
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly + H2O
?
show the reaction diagram
-
-
-
-
?
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH3 + H2O
?
show the reaction diagram
-
-
-
-
?
Arg-Pro-Pro + H2O
?
show the reaction diagram
-
-
-
-
?
Asn-Pro-4-nitroanilide + H2O
Asn-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Asn-Pro-4-nitroanilide + H2O
Asn-Pro + 4-nitroaniline
show the reaction diagram
-
poor substrate
-
?
Asn-Pro-7-amido-4-methylcoumarin + H2O
Asn-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Asp-Pro-4-nitroanilide + H2O
Asp-Pro + 4-nitroaniline
show the reaction diagram
-
low activity
-
?
Asp-Pro-4-nitroanilide + H2O
Asp-Pro + 4-nitroaniline
show the reaction diagram
Q673U2, -
11% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Asp-Pro-7-amido-4-methylcoumarin + H2O
Asp-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
low activity
-
?
B-type natriuretic peptide (1-32) + H2O
B-type natriuretic peptide (3-32) + L-Ser-L-Pro
show the reaction diagram
-
DPP IV removes the two amino terminal amino acids (Ser-Pro) from B-type natriuretic peptide (1-32) to produce B-type natriuretic peptide (3-32)
-
-
?
B-type natriuretic peptide(1-32) + H2O
B-type natriuretic peptide(3-32) + ?
show the reaction diagram
-
-
-
-
?
B-type natriuretic propeptide (1-108) + H2O
B-type natriuretic propeptide (3-306) + ?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Gly-Gly-Pro-Ala + H2O
Gly-Gly-Pro + Gly-Gly-Pro-Ala + Ala + Gly-Pro + Gly-Pro-Ala + ?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Leu-Gly-Pro + H2O
Leu-Gly-Pro + ?
show the reaction diagram
-
-
-
?
beta-casein + H2O
?
show the reaction diagram
Lactococcus lactis, Lactococcus lactis P8-2-47
-
cleavage of the proline-rich sequence
-
-
?
beta-casomorphin + H2O
?
show the reaction diagram
-
-
-
-
?
beta-casomorphin + H2O
?
show the reaction diagram
-
-
-
-
?
beta-casomorphin + H2O
?
show the reaction diagram
-
beta-casomorphin from human, i.e. Tyr-Pro-Phe-Val-Glu-Pro-Ileu, beta-casomorphin from bovine, i.e. Tyr-Pro-Phe-Val-Glu-Pro-Ile
-
-
?
beta-casomorphin + H2O
?
show the reaction diagram
-
Tyr-Pro-/-Phe-Pro-/-Gly
-
-
?
beta-casomorphin + H2O
?
show the reaction diagram
Lactococcus lactis NCDO 763
-
-
-
-
?
beta-casomorphin + H2O
?
show the reaction diagram
Lactococcus lactis nTR
-
-
-
-
?
beta-casomorphin + H2O
fragments
show the reaction diagram
-
cleavage sites: YP-/-FP-/-GP-/-IGP-/-RP
-
?
beta-endorphin + H2O
?
show the reaction diagram
-
-
-
-
?
Bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
BRI peptide (1-23) + H2O
?
show the reaction diagram
-
-
-
-
?
casomorphin + H2O
?
show the reaction diagram
-
-
-
-
?
CCL11 + H2O
CCL11(3-74) + ?
show the reaction diagram
-
-
-
-
?
chemokines + H2O
?
show the reaction diagram
-
-
-
?
corticotropin-like intermediate lobe peptide + H2O
?
show the reaction diagram
-
-
-
-
?
CXCL 11 + H2O
?
show the reaction diagram
-
chemokine bound to receptor on T cell surface
-
?
des-Pro2-bradykinin + H2O
fragments
show the reaction diagram
-
cleavage sites: RP-/-GFSPFR
-
?
enterostatin + H2O
?
show the reaction diagram
-
-
-
-
?
enterostatin + H2O
?
show the reaction diagram
-
-
-
-
?
enterostatin + H2O
?
show the reaction diagram
-
i.e. Val-Pro-/-Asn-Pro-/-Arg
-
-
?
eotaxin + H2O
?
show the reaction diagram
-
i.e. CCL11, chemokine
-
?
EPLGRQLTSGP + H2O
Glu-Pro + LGRQLTSGP
show the reaction diagram
-
the sequence EPLGRQLTSGP, which corresponds to the propeptide fragment of alpha-2 plasmin inhibitor
-
-
?
gastric inhibitory polypeptide + H2O
?
show the reaction diagram
-
-
-
-
?
gastrin releasing peptide + H2O
?
show the reaction diagram
-
-
-
-
?
gastrin releasing peptide + H2O
?
show the reaction diagram
-
sequential cleavage of 2 N-terminal peptides
-
?
gastrin releasing peptide-(1-27) + H2O
?
show the reaction diagram
-
i.e. GRP-(1-27), cleaves N-terminal dipeptide VP
-
ir
gastrin releasing peptide-(3-27) + H2O
?
show the reaction diagram
-
i.e. GRP-(3-27), cleaves N-terminal dipeptide LP
-
ir
gastrin-releasing peptide + H2O
?
show the reaction diagram
-
-
-
-
?
Gln-Pro-7-amido-4-methylcoumarin + H2O
Gln-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
GLP-1 + H2O
?
show the reaction diagram
-
an incretin involved in the glucose-dependent production of insulin
-
?
Glu-Pro-4-methylcoumarin 7-amide + H2O
Glu-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Glu-Pro-4-nitroanilide + H2O
Glu-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Glu-Pro-4-nitroanilide + H2O
Glu-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Glu-Pro-4-nitroanilide + H2O
Glu-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Glu-Pro-4-nitroanilide + H2O
Glu-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Glu-Pro-4-nitroanilide + H2O
Glu-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Glu-Pro-4-nitroanilide + H2O
Glu-Pro + 4-nitroaniline
show the reaction diagram
-, Q6F3I7
-
-
-
?
Glu-Pro-4-nitroanilide + H2O
Glu-Pro + 4-nitroaniline
show the reaction diagram
-
23% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Glu-Pro-4-nitroanilide + H2O
Glu-Pro + 4-nitroaniline
show the reaction diagram
Q6F3I7
-
-
-
?
Glu-Pro-7-amido-4-methylcoumarin + H2O
Glu-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
low activity
-
?
Glucagon + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 (7-36)-amide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 (7-37) + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
i.e. GLP 1
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
i.e. GLP-1, degradation, regulation of activity
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
i.e. GLP-1, degradation, regulation of activity
-
ir
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
i.e. GLP-1, incretin, degradation, regulation of activity
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
i.e. GLP-1, degradation, regulation of activity, cleaves N-terminal dipeptide HA
-
ir
glucagon-like peptide 1 + H2O
?
show the reaction diagram
Mus musculus NOD/LtJ
-
-
-
-
?
glucagon-like peptide 2 (1-33) + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 2 + H2O
?
show the reaction diagram
-
i.e. GLP 2
-
?
glucagon-like peptide 2 + H2O
?
show the reaction diagram
-
i.e. GLP-1, degradation, regulation of activity, cleaves N-terminal dipeptide HA
-
ir
glucagon-like peptide-1 (7-36)-amide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide-1 + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide-1 + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide-1 + H2O
?
show the reaction diagram
-
i.e. GLP-1, degradation
-
?
glucagon-like peptide-1 + H2O
?
show the reaction diagram
-
dipeptidyl peptidase IV inactivates the hormone, thereby cancelling the prandial insulinotropic effect
-
-
?
glucagon-like peptide-1 + H2O
?
show the reaction diagram
-
dipeptidyl peptidase-IV is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1and glucose-dependent insulinotropic polypeptide
-
-
?
glucagon-like peptide-1 + H2O
?
show the reaction diagram
-
DPP-IV is the main proteolytic enzyme responsible for the rapid inactivation of glucagon-like peptide-1 into metabolites that are devoid of insulin-releasing activity
-
-
?
glucagon-like peptide-2 + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic peptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic peptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic peptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic peptide + H2O
?
show the reaction diagram
Mus musculus NOD/LtJ
-
-
-
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
i.e. GIP
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
i.e. GIP, incretin
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
i.e. GIP, cleaves N-terminal dipeptide YA
-
ir
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
dipeptidyl peptidase IV inactivates the hormone, thereby cancelling the prandial insulinotropic effect
-
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
dipeptidyl peptidase-IV is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1and glucose-dependent insulinotropic polypeptide
-
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
DPP-IV is the main proteolytic enzyme responsible for the rapid inactivation of glucose-dependent insulinotropic polypeptide into metabolites that are devoid of insulin-releasing activity
-
-
?
glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O
?
show the reaction diagram
-
GIP-fragment
-
?
glucose-dependent insulinotropic polypeptide(1-42) peptide + H2O
?
show the reaction diagram
-
GIP-fragment
-
?
glucose-dependent insulinotropic polypeptide(1-6) peptide + H2O
?
show the reaction diagram
-
GIP-fragment, very low activity
-
?
glucosedependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
-
-
-
?
Gly-4-nitroanilide + H2O
Gly + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Ala-4-methylcoumarin 7-amide + H2O
Gly-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Ala-4-nitroanilide + H2O
Gly-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Ala-4-nitroanilide + H2O
Gly-Ala + 4-nitroaniline
show the reaction diagram
-
poor substrate
-
?
Gly-Ala-4-nitroanilide + H2O
Gly-Ala + 4-nitroaniline
show the reaction diagram
-
low activity
-
?
Gly-azetidine-3,5-dibromo-4-hydroxyanilide + H2O
Gly-azetidine + 3,5-dibromo-4-hydroxyaniline
show the reaction diagram
-
-
-
-
?
Gly-hydroxyproline-4-nitroanilide + H2O
Gly-hydroxyproline + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-hydroxyproline-4-nitroanilide + H2O
Gly-hydroxyproline + 4-nitroaniline
show the reaction diagram
-
10% of the activity with Gly-Pro-4-nitroanilide
-
?
Gly-Hyp-Ala + H2O
Ala + ?
show the reaction diagram
-
-
-
?
Gly-L-Ala-2-naphthylamide + H2O
Gly-L-Ala + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Gly-L-hydroxyproline-3,5-dibromo-4-hydroxyanilide + H2O
Gly-L-hydroxyproline + 3,5-dibromo-4-hydroxyaniline
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-4-methoxy-beta-naphthylamide + H2O
Gly-L-Pro + 4-methoxy-beta-naphthylamine
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-4-nitroanilide
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-4-nitroanilide
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-4-nitroanilide
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-4-nitroanilide
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-4-nitroanilide
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-4-nitroanilide + H2O
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-4-nitroanilide + H2O
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-4-nitroanilide + H2O
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-4-nitroanilide + H2O
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
Gly-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
Gly-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
Gly-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
Gly-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
Gly-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
Mus musculus NOD/LtJ
-
-
-
-
?
Gly-L-Pro-Gly-Gly + H2O
?
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-L-Ala + H2O
Gly-L-Pro + L-Ala
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-L-Ala + H2O
Gly-L-Pro + L-Ala
show the reaction diagram
-
-
-
?
Gly-L-Pro-L-Ala + H2O
Gly-L-Pro + L-Ala
show the reaction diagram
-
-
-
?
Gly-L-Pro-L-Ala + H2O
Gly-L-Pro + L-Ala
show the reaction diagram
Lactococcus lactis, Lactococcus lactis nTR
-
-
-
-
?
Gly-L-Pro-p-nitroanilide + H2O
L-Lys-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Phe-4-nitroanilide + H2O
Gly-Phe + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Phe-4-nitroanilide + H2O
Gly-Phe + 4-nitroaniline
show the reaction diagram
-
1% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Gly-Pro-2-naphthylamide + H2O
Gly-Pro + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Gly-Pro-2-naphthylamide + H2O
Gly-Pro + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Gly-Pro-2-naphthylamide + H2O
Gly-Pro + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Gly-Pro-2-naphthylamide + H2O
Gly-Pro + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Gly-Pro-2-naphthylamide + H2O
Gly-Pro + 2-naphthylamine
show the reaction diagram
-
L-Gly-Pro-2-naphthylamide
-
-
?
Gly-Pro-3,5-dibromo-4-hydroxyanilide + H2O
Gly-Pro + 3,5-dibromo-4-hydroxyaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-methoxy-2-naphthylamide
Gly-Pro + 4-methoxy-2-naphthylamine
show the reaction diagram
P27487
fluorogenic substrate
-
?
Gly-Pro-4-methoxy-2-naphthylamide + H2O
Gly-Pro + 4-methoxy-2-naphthylamine
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-methoxy-2-naphthylamide + H2O
Gly-Pro + 4-methoxy-2-naphthylamine
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-methoxy-beta-naphthylamide + H2O
Gly-Pro + 4-methoxy-beta-naphthylamine
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
-
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
P27487
-
-
-
?
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-, Q75S82, Q75S83
-
-
-
?
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
Lactococcus lactis H1
-
-
-
-
?
Gly-Pro-4-methylcoumarin-7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-methylcoumaryl-7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-methylcoumaryl-7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
P27487
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
P27487
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
O66223, -
-
-
-
-
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
P27487
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
P14740
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
O66223, -
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
Q673U2, -
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
low activity
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
Streptococcus salivarius HHT
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
Streptococcus thermophilus ACA-DC 4
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
Lactobacillus helveticus LHE-511
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
Lactococcus lactis NCDO 763
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
Lactococcus lactis H1
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
Lactococcus lactis P8-2-47
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
Lactococcus lactis nTR
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
Lactobacillus helveticus CNRZ 32
-
-
-
-
?
Gly-Pro-7-amido-4-methyl coumarin + H2O
Gly-Pro + 7-amino-4-methyl coumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-7-amido-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-7-amido-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Gly-Pro-7-amido-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Gly-Pro-7-amido-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-7-amido-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Gly-Pro-7-amido-4-trifluoromethyl coumarin + H2O
Gly-Pro + 7-amino-4-trifluoromethyl coumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-7-amino-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-7-amino-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-Arg + H2O
Gly-Pro + Arg
show the reaction diagram
Lactobacillus helveticus, Lactobacillus helveticus LHE-511
-
-
-
-
?
Gly-Pro-Arg-Pro + H2O
?
show the reaction diagram
Streptococcus thermophilus, Streptococcus thermophilus ACA-DC 4
-
as active as with Gly-Pro-4-nitroanilide
-
-
?
Gly-Pro-beta-naphthylamide + H2O
Gly-Pro + beta-naphthylamine
show the reaction diagram
-
-
-
-
?
Gly-Pro-glycinamide + H2O
?
show the reaction diagram
-
CD26 plays a direct regulatory and indispensable role in the eventual antiretroviral activity of small synthetic molecules such as the antiretroviral prodrug Gly-Pro-glycinamide
-
-
?
Gly-Pro-glycinamide + H2O
Gly-Pro + glycinamide
show the reaction diagram
-
the anti-HIV drug Gly-Pro-glycinamide is not active as such, but rather behaves as a prodrug that must be obligatorily cleaved by VD26/DPP IV to Gly-Pro and glycinamide to exert its antiretroviral activity
-
-
?
Gly-Pro-Leu-Gly-Pro + H2O
?
show the reaction diagram
-
11% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Gly-Pro-p-nitoanilide + H2O
Gly-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
show the reaction diagram
Rattus norvegicus Wistar
-
-
-
-
?
growth hormone releasing factor + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone releasing hormone (1-29) + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone releasing hormone (1-44) + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone releasing hormone-(1-29) fragment + H2O
?
show the reaction diagram
-
i.e. GHRH-(1-29), cleaves N-terminal dipeptide YA
-
ir
growth hormone releasing hormone-(1-44) fragment + H2O
?
show the reaction diagram
-
i.e. GHRH-(1-44), cleaves N-terminal dipeptide YA
-
ir
growth hormone-(1-43) fragment + H2O
?
show the reaction diagram
-
-
-
?
growth hormone-(1-43) fragment + H2O
?
show the reaction diagram
-
cleaves N-terminal dipeptide FP
-
ir
growth hormone-releasing hormone + H2O
?
show the reaction diagram
-
-
-
-
?
H-Ala-L-Pro-7-amido-4-methylcoumarin + H2O
H-Ala-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
hemorphin-4 + H2O
YP + WT
show the reaction diagram
-
-
-
?
hemorphin-5 + H2O
YP + WTQ
show the reaction diagram
-
-
-
?
hemorphin-7 + H2O
YP + WTQRF
show the reaction diagram
-
-
-
?
His-Ala-4-nitroanilide + H2O
His-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
His-Ala-4-nitroanilide + H2O
His-Ala + 4-nitroaniline
show the reaction diagram
-
poor substrate
-
?
His-Pro-4-nitroanilide + H2O
His-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
His-Pro-4-nitroanilide + H2O
His-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
His-Pro-4-nitroanilide + H2O
His-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
His-Pro-4-nitroanilide + H2O
His-Pro + 4-nitroaniline
show the reaction diagram
-
low activity
-
?
His-Pro-7-amido-4-methylcoumarin + H2O
His-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
His-Pro-Leu + H2O
?
show the reaction diagram
-
-
-
-
?
His-Pro-Phe + H2O
His-Pro + Phe
show the reaction diagram
-
-
-
?
His-Pro-Tyr + H2O
?
show the reaction diagram
-
-
-
-
?
Hly-Pro-2-naphthylamide
?
show the reaction diagram
-
-
-
-
?
human chorionic gonadotropin alpha + H2O
?
show the reaction diagram
-
-
-
-
?
human glucagon-like peptide 1 (7-36) + H2O
?
show the reaction diagram
-
i.e. His-Ala-/-Glu-Gly-Thr-Phe-Thr-Ser-Asp
-
-
?
human glucagon-like peptide 2 + H2O
?
show the reaction diagram
-
i.e. His-Ala-/-Asp-Gly-Ser-Phe-Ser-Asp-Glu
-
-
?
human glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
i.e. Tyr-Ala-/-Glu-Gly-Thr-Phe-Thr-Ser-Asp-
-
-
?
human growth hormone-releasing factor + H2O
?
show the reaction diagram
-
i.e. Tyr-Ala-/-Asp-Ala-Ile-Phe-Thr-Asn-Ser-
-
-
?
human neuropeptide Y + H2O
Tyr-Pro + Ser-Lys-Pro-Asp-Asn-Pro-Gly
show the reaction diagram
-
i.e. Tyr-Pro-/-Ser-Lys-Pro-Asp-Asn-Pro-Gly
-
-
?
human peptide YY + H2O
Tyr-Pro + Ile-Lys-Pro-Glu-Ala-Pro-Gly-
show the reaction diagram
-
i.e. Tyr-Pro-/-Ile-Lys-Pro-Glu-Ala-Pro-Gly-
-
?
IFN-gamma-inducible protein 10 + H2O
?
show the reaction diagram
-
i.e. IP-10 or CXCL10, chemokine
-
?
IFN-inducible T-cell alpha-chemoattractant + H2O
?
show the reaction diagram
-
i.e. I-TAC or CXCL11, chemokine
-
?
Ile-Pro-4-nitroanilide + H2O
Ile-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Ile-Pro-4-nitroanilide + H2O
Ile-Pro + 4-nitroaniline
show the reaction diagram
-
low activity
-
?
Ile-Pro-7-amido-4-methylcoumarin + H2O
Ile-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Ile-Pro-Ile + H2O
?
show the reaction diagram
-
-
-
-
?
Ile-Pro-Ile + H2O
?
show the reaction diagram
-
34% of the activity with Gly-Pro-4-nitroanilide
-
-
?
incretin hormone + H2O
?
show the reaction diagram
-
-
-
?, ir
incretin hormone glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
i.e. GLP-1, degradation, regulation of activity
-
?
incretins + H2O
?
show the reaction diagram
-
-
-
?
insulin-like growth factor-1 + H2O
?
show the reaction diagram
-
-
-
-
?
interferon-gamma-inducible protein-10 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin 1-beta + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-2 + H2O
?
show the reaction diagram
-
-
-
-
?
kentsin + H2O
Thr-Pro + ?
show the reaction diagram
-
-
-
?
L-Ala-L-Ala-L-Ala-L-Ala + H2O
L-Ala-L-Ala
show the reaction diagram
-
-
-
?
L-Ala-L-Ala-L-Ala-L-Ala + H2O
L-Ala-L-Ala
show the reaction diagram
-
-
with traces of Ala3 and Ala after 2.5 h incubation
?
L-Ala-L-Pro-4-nitroanilide
L-Ala-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Ala-L-Pro-4-nitroanilide
L-Ala-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Ala-L-Pro-4-nitroanilide
L-Ala-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Ala-L-Pro-4-nitroanilide
L-Ala-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Ala-L-Pro-7-amido-4-methylcoumarin + H2O
L-Ala-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Ala-L-Pro-7-amido-4-methylcoumarin + H2O
L-Ala-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Ala-L-Pro-7-amido-4-trifluoromethylcoumarin + H2O
L-Ala-L-Pro + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Ala-L-Pro-p-nitroanilide + H2O
L-Ala-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Arg-L-Pro-4-nitroanilide
L-Arg-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Arg-L-Pro-7-amido-4-methylcoumarin + H2O
L-Arg-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Arg-L-Pro-p-nitroanilide + H2O
L-Arg-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Asn-L-Pro-p-nitroanilide + H2O
L-Asn-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Asp-L-Pro-6-aminoquinolide + H2O
L-Asp-L-Pro + 6-aminoquinoline
show the reaction diagram
-
-
-
-
?
L-Asp-L-Pro-p-nitroanilide + H2O
L-Asp-L-Pro + p-nitroaniline
show the reaction diagram
-
least preferred substrate
-
-
?
L-Glu-L-Pro-4-nitroanilide
L-Glu-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Glu-L-Pro-p-nitroanilide + H2O
L-Glu-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Leu-L-Ala-2-naphthylamide + H2O
L-Leu-L-Ala + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
L-Leu-L-Leu-Gly + H2O
?
show the reaction diagram
-
-
-
-
-
L-Leu-L-Leu-L-Leu + H2O
?
show the reaction diagram
-
-
-
-
?
L-Leu-L-Leu-L-Val-L-Tyr-L-Ser + H2O
Leu-Leu + Val-Tyr + Ser
show the reaction diagram
-
-
-
?
L-Leu-L-Pro-Gly-Gly + H2O
?
show the reaction diagram
-
-
-
-
?
L-Leu-L-Pro-p-nitroanilide + H2O
L-Leu-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Lys-L-Ala-2-naphthylamide + H2O
L-Lys-L-Ala + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
L-Lys-L-Pro-p-nitroanilide + H2O
Gly-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Lys-L-Pro-p-nitroanilide + H2O
L-Lys-L-Pro + p-nitroaniline
show the reaction diagram
-
most preferred substrate
-
-
?
L-Met-L-Pro-p-nitroanilide + H2O
L-Met-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Pro-L-Ala-7-amido-4-trifluoromethylcoumarin + H2O
L-Pro-L-Ala + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
-
?
L-Ser-L-Pro-p-nitroanilide + H2O
L-Ser-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Val-L-Ala-L-Val-L-Pro + H2O
?
show the reaction diagram
-
-
-
-
?
L-Val-L-Pro-6-aminoquinolide + H2O
L-Val-L-Pro + 6-aminoquinoline
show the reaction diagram
-
-
-
-
?
L-Val-L-Pro-doxorubicin + H2O
L-Val-L-Pro + doxorubicin
show the reaction diagram
-
-
-
-
?
L-Val-L-Pro-L-Val-L-Pro-beta-D-arabinofuranosyladenosine + H2O
L-Val-L-Pro-L-Val-L-Pro + beta-D-arabinofuranosyladenosine
show the reaction diagram
-
-
-
-
?
L-Val-L-Pro-L-Val-L-Pro-beta-D-arabinofuranosylcytosine + H2O
L-Val-L-Pro-L-Val-L-Pro + beta-D-arabinofuranosylcytosine
show the reaction diagram
-
-
-
-
?
Leu-Ala-Pro + H2O
?
show the reaction diagram
-
-
-
-
?
Leu-Pro-4-methylcoumarin 7-amide + H2O
Leu-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Leu-Pro-7-amido-4-methylcoumarin + H2O
Leu-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
leutinising hormone alpha chain + H2O
?
show the reaction diagram
-
-
-
-
?
Lys-Ala-4-methylcoumarin 7-amide + H2O
Lys-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Lys-Ala-4-methylcoumarin 7-amide + H2O
Lys-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Lys-Ala-4-methylcoumarin 7-amide + H2O
Lys-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Lys-Ala-4-methylcoumarin 7-amide + H2O
Lys-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-, Q75S82, Q75S83
8.7% of the activity with Pro-4-methylcoumarin 7-amide
-
-
?
Lys-Ala-4-methylcoumarin 7-amide + H2O
Lys-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
Lactococcus lactis H1
-
-
-
-
?
Lys-Ala-4-nitroanilide + H2O
Lys-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
Lys-Ala-7-amido-4-methylcoumarin + H2O
Lys-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Lys-Ala-7-amido-4-methylcoumarin + H2O
Lys-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
-
Lys-Ala-Val-Pro-Tyr-Pro-Gln + H2O
?
show the reaction diagram
-
-
-
-
?
Lys-Pro-4-methoxy-2-naphthylamide + H2O
Lys-Pro + 4-methoxy-2-naphthylamine
show the reaction diagram
-
-
-
-
?
Lys-Pro-4-methoxy-2-naphthylamide + H2O
Lys-Pro + 4-methoxy-2-naphthylamine
show the reaction diagram
-
-
-
-
?
Lys-Pro-4-methoxy-2-naphthylamide + H2O
Lys-Pro + 4-methoxy-2-naphthylamine
show the reaction diagram
-
-
-
-
?
Lys-Pro-4-methylcoumarin 7-amide + H2O
Lys-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Lys-Pro-4-nitroanilide + H2O
Lys-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Lys-Pro-4-nitroanilide + H2O
Lys-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Lys-Pro-4-nitroanilide + H2O
Lys-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Lys-Pro-4-nitroanilide + H2O
Lys-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Lys-Pro-4-nitroanilide + H2O
Lys-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Lys-Pro-4-nitroanilide + H2O
Lys-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Lys-Pro-4-nitroanilide + H2O
Lys-Pro + 4-nitroaniline
show the reaction diagram
-
34% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Lys-Pro-4-nitroanilide + H2O
Lys-Pro + 4-nitroaniline
show the reaction diagram
-
48.6% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Lys-Pro-4-nitroanilide + H2O
Lys-Pro + 4-nitroaniline
show the reaction diagram
-
65% of the activity with Gly-Pro-4-nitroanilide
-
?
Lys-Pro-4-nitroanilide + H2O
Lys-Pro + 4-nitroaniline
show the reaction diagram
Q673U2, -
51% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Lys-Pro-4-nitroanilide + H2O
Lys-Pro + 4-nitroaniline
show the reaction diagram
Streptococcus salivarius HHT
-
48.6% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Lys-Pro-7-amido-4-methylcoumarin + H2O
Lys-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Lys-Pro-7-amido-4-methylcoumarin + H2O
Lys-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
best substrate
-
?
Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
macrophage-derived chemokine + H2O
?
show the reaction diagram
-
-
-
-
?
macrophage-derived chemokine + H2O
?
show the reaction diagram
-
i.e. MDC or CCL22
-
?
Met-Pro-4-nitroanilide + H2O
Met-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Met-Pro-7-amido-4-methylcoumarin + H2O
Met-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
monocyte chemotactic protein-1 + H2O
?
show the reaction diagram
-
-
-
-
?
monocyte chemotactic protein-2 + H2O
?
show the reaction diagram
-
-
-
-
?
N-(Ala-Pro)-N'-6-(3,4-dichloromaleimidyl)-hexanoyl-rhodamine 110 + H2O
Ala-Pro + N-6-(3,4-dichloromaleimidyl)-hexanoyl-rhodamine 110
show the reaction diagram
-
fluorogenic substrate
-
?
N-(Ala-Pro)-N'-6-(3,4-dichloromaleimidyl)-hexanoyl-rhodamine 110 + H2O
Ala-Pro + N-6-(3,4-dichloromaleimidyl)-hexanoyl-rhodamine 110
show the reaction diagram
-
fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay
-
?
N-(Gly-Pro)-N'-(4-chlorobutanoyl)-rhodamine 110 + H2O
Gly-Pro + N-(4-chlorobutanoyl)-rhodamine 110
show the reaction diagram
-
fluorogenic substrate
-
?
N-(Gly-Pro)-N'-(4-chlorobutanoyl)-rhodamine 110 + H2O
Gly-Pro + N-(4-chlorobutanoyl)-rhodamine 110
show the reaction diagram
-
fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay
-
?
N-(Gly-Pro)-N'-(4-chloromethyl)benzoyl-rhodamine 110 + H2O
Gly-Pro + N-(4-chloromethyl)benzoyl-rhodamine 110
show the reaction diagram
-
fluorogenic substrate
-
?
N-(Gly-Pro)-N'-(4-chloromethyl)benzoyl-rhodamine 110 + H2O
Gly-Pro + N-(4-chloromethyl)benzoyl-rhodamine 110
show the reaction diagram
-
fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay
-
?
N-(Gly-Pro)-N'-(5-bromopentanoyl)-rhodamine 110 + H2O
Gly-Pro + N-(5-bromopentanoyl)-rhodamine 110
show the reaction diagram
-
fluorogenic substrate
-
?
N-(Gly-Pro)-N'-(5-bromopentanoyl)-rhodamine 110 + H2O
Gly-Pro + N-(5-bromopentanoyl)-rhodamine 110
show the reaction diagram
-
fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay
-
?
N-(Gly-Pro)-N'-(5-chloropentanoyl)-rhodamine 110 + H2O
Gly-Pro + N-(5-chloropentanoyl)-rhodamine 110
show the reaction diagram
-
-
-
?
N-(Gly-Pro)-N'-(5-chloropentanoyl)-rhodamine 110 + H2O
Gly-Pro + N-(5-chloropentanoyl)-rhodamine 110
show the reaction diagram
-
fluorogenic substrate
-
?
N-(Gly-Pro)-N'-(5-chloropentanoyl)-rhodamine 110 + H2O
Gly-Pro + N-(5-chloropentanoyl)-rhodamine 110
show the reaction diagram
-
fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay
-
?
N-(Gly-Pro)-N'-4-(maleimidyl)butanoyl-rhodamine 110 + H2O
Gly-Pro + N-4-(maleimidyl)butanoyl-rhodamine 110
show the reaction diagram
-
fluorogenic substrate
-
?
N-(Gly-Pro)-N'-4-(maleimidyl)butanoyl-rhodamine 110 + H2O
Gly-Pro + N-4-(maleimidyl)butanoyl-rhodamine 110
show the reaction diagram
-
fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay
-
?
N-(Gly-Pro)-N'-6-(maleimidyl)hexanoyl-rhodamine 110 + H2O
Gly-Pro + N-6-(maleimidyl)hexanoyl-rhodamine 110
show the reaction diagram
-
fluorogenic substrate
-
?
N-(Gly-Pro)-N'-6-(maleimidyl)hexanoyl-rhodamine 110 + H2O
Gly-Pro + N-6-(maleimidyl)hexanoyl-rhodamine 110
show the reaction diagram
-
fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay
-
?
N-(Gly-Pro)-N'-acetyl-rhodamine 110 + H2O
Gly-Pro + N-acetyl-rhodamine 110
show the reaction diagram
-
fluorogenic substrate
-
?
N-(Gly-Pro)-N'-acetyl-rhodamine 110 + H2O
Gly-Pro + N-acetyl-rhodamine 110
show the reaction diagram
-
fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay
-
?
N-(Gly-Pro)-N'-chloroacetyl-rhodamine 110 + H2O
Gly-Pro + N-chloroacetyl-rhodamine 110
show the reaction diagram
-
fluorogenic substrate
-
?
N-(Gly-Pro)-N'-chloroacetyl-rhodamine 110 + H2O
Gly-Pro + N-chloroacetyl-rhodamine 110
show the reaction diagram
-
fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay
-
?
N-terminal B-type natriuretic propeptide (1-76) + H2O
N-terminal B-type natriuretic propeptide (3-76) + ?
show the reaction diagram
-
-
-
-
?
N-tosyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
N-tosyl-Gly-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
neuropeptide Y + H2O
?
show the reaction diagram
-
-
-
-
?
neuropeptide Y + H2O
?
show the reaction diagram
-
-
-
-
?
neuropeptide Y + H2O
?
show the reaction diagram
-
-
-
-
?
norleucine-Pro-7-amido-4-methylcoumarin + H2O
norleucine-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
norleucine-Pro-rhodamine + H2O
norleucine-Pro + rhodamine
show the reaction diagram
-
-
-
?
NPY + H2O
?
show the reaction diagram
-
important step in the neuropeptide-Y NPY-mediated angiogenesis
-
?
NPY(1-36) peptide + H2O
?
show the reaction diagram
-
peptide derived from the neuropeptide-Y
-
?
NPY(3-36) peptide + H2O
?
show the reaction diagram
-
peptide derived from the neuropeptide-Y
-
?
oxyntomodulin + H2O
?
show the reaction diagram
-
-, cleaves N-terminal dipeptide HS
-
ir
peptide YY (1-36) + H2O
?
show the reaction diagram
-
-
-
-
?
peptide YY + H2O
?
show the reaction diagram
-
-
-
-
?
peptide YY + H2O
?
show the reaction diagram
-
-
-
-
?
peptide YY + H2O
peptide YY fragment 3-36
show the reaction diagram
-
high affinity substrate of DPP-IV
-
-
?
Phe-4-nitroanilide + H2O
Phe + 4-nitroaniline
show the reaction diagram
Streptococcus thermophilus, Streptococcus thermophilus ACA-DC 4
-
7% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Phe-Ala-4-nitroanilide + H2O
Phe-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
Phe-Ala-Pro-2-naphthylamide + H2O
?
show the reaction diagram
-
-
-
-
?
Phe-Pro-2-naphthylamide + H2O
Phe-Pro + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Phe-Pro-2-naphthylamide + H2O
Phe-Pro + 2-naphthylamine
show the reaction diagram
-
L-Phe-L-Pro-2-naphthylamide
-
-
?
Phe-Pro-4-methylcoumarin 7-amide + H2O
Phe-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Phe-Pro-4-methylcoumarin 7-amide + H2O
Phe-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Phe-Pro-4-methylcoumarin 7-amide + H2O
Phe-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-, Q75S82, Q75S83
108.6% of the activity with Pro-4-methylcoumarin 7-amide
-
-
?
Phe-Pro-4-methylcoumarin 7-amide + H2O
Phe-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
Lactococcus lactis H1
-
-
-
-
?
Phe-Pro-4-nitroanilide + H2O
Phe-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Phe-Pro-4-nitroanilide + H2O
Phe-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Phe-Pro-4-nitroanilide + H2O
Phe-Pro + 4-nitroaniline
show the reaction diagram
-
low activity
-
?
Phe-Pro-7-amido-4-methylcoumarin + H2O
Phe-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
-
Phe-Pro-7-amido-4-methylcoumarin + H2O
Phe-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
low activity
-
?
pituitary adenylate cyclase activating peptide + H2O
?
show the reaction diagram
-
-
-
-
?
pituitary adenylate cyclase-activating polypeptide + H2O
?
show the reaction diagram
-
pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with promising therapeutic applications for the treatment of several pathophysiological states related to neurodegenerative diseases. However, its use for therapeutic applications is actually limited by its restricted bioavailability and rapid degradation. N-terminal modifications confer resistance to dipeptidyl peptidase IV, a major proteolytic process involved in PACAP degradation
-
-
?
pituitary adenylate cyclase-activating polypeptide-(1-27) + H2O
?
show the reaction diagram
-
i.e. PACAP27, cleaves N-terminal dipeptide HS
-
?
pituitary adenylate cyclase-activating polypeptide-(1-38) + H2O
?
show the reaction diagram
-
i.e. PACAP38, a critical mediator in lipid and carbohydrate metabolism, i.e. PACAP38, enzyme plays a major role in the degradation of circulating PACAP38, cleaves N-terminal dipeptide HS
-
?
Pro-4-nitroanilide + H2O
Pro + 4-nitroaniline
show the reaction diagram
-
2% of the activity with Gly-Pro-4-nitroanilide
-
-
?
Pro-Ala-4-nitroanilide + H2O
Pro-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
Pro-Ala-4-nitroanilide + H2O
Pro-Ala + 4-nitroaniline
show the reaction diagram
-
best substrate
-
?
pro-colipase + H2O
?
show the reaction diagram
-
-
-
-
?
Pro-Pro-4-nitroanilide + H2O
Pro-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Pro-Pro-4-nitroanilide + H2O
Pro-Pro + 4-nitroaniline
show the reaction diagram
-
high activity
-
?
Pro-Pro-7-amido-4-methylcoumarin + H2O
Pro-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Pro-Pro-Gly + H2O
Gly + ?
show the reaction diagram
-
-
-
?
procasomorphin + H2O
?
show the reaction diagram
-
-
-
-
?
procolipase + H2O
?
show the reaction diagram
-
-
-
-
?
prolactin + H2O
?
show the reaction diagram
-
-
-
-
?
promastoparan + H2O
mastoparan + ?
show the reaction diagram
-
-
-
-
?
QPDAINAP + H2O
Gln-Pro + DAINAP
show the reaction diagram
O66223, -
peptide sequence corresponds to the N-terminus of human MCP1 protein
-
?
RANTES + H2O
?
show the reaction diagram
-
i.e. CCL5 or regulated on activation normal T-cell expressed and secreted, chemokine
-
?
RANTES protein + H2O
?
show the reaction diagram
-
-
-
-
?
SDF-1/CXCL12 + H2O
?
show the reaction diagram
-
CD26 may play a role in SDF-1/CXCL12 mediated functions such as chemotaxis
-
-
?
SDF-1/CXCL12 + H2O
?
show the reaction diagram
-
CD26 can cleave SDF-1/CXCL12 to a chemotactically-null molecule
-
-
?
Ser-Pro-4-nitroanilide + H2O
Ser-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Ser-Pro-4-nitroanilide + H2O
Ser-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Ser-Pro-4-nitroanilide + H2O
Ser-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Ser-Pro-4-nitroanilide + H2O
Ser-Pro + 4-nitroaniline
show the reaction diagram
-
low activity
-
?
Ser-Pro-7-amido-4-methylcoumarin + H2O
Ser-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
SPYSSDTT + H2O
Ser-Pro + YSSDTT
show the reaction diagram
O66223, -
peptide sequence corresponds to the N-terminus of human RANTES protein
-
?
stromal cell derived factor 1 + H2O
?
show the reaction diagram
-
i.e. SDF-1 or CXCL12, chemokine
-
?
stromal cell-derived factor 1alpha + H2O
?
show the reaction diagram
-
-
-
-
?
stromal cell-derived factor 1beta + H2O
?
show the reaction diagram
-
-
-
-
?
stromal cell-derived factor-1 + H2O
?
show the reaction diagram
-
-
-
-
?
Substance P + H2O
?
show the reaction diagram
-
-
-
-
?
substance P + H2O
Arg-Pro + Lys-Pro + ?
show the reaction diagram
-
-
-
?
substance P + H2O
Arg-Pro + Lys-Pro + ?
show the reaction diagram
-
-
-
-
?
substance P + H2O
Arg-Pro + Lys-Pro + ?
show the reaction diagram
-
-
-
-
?
substance P + H2O
Arg-Pro + Lys-Pro + ?
show the reaction diagram
-
Arg-Pro-/-Lys-Pro-/-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
-
-
?
substance P + H2O
fragments
show the reaction diagram
-
cleavage sites: RP-/-KP-/-QQFFGLM
-
?
substance P + H2O
peptides SP(3-11) + SP(5-11)
show the reaction diagram
-
i.e. SP, sequential cleavage of full length substance P
both fragments are still active
?
synthetic renin inhibitor + H2O
?
show the reaction diagram
-
His-Pro-Phe-His-Leu-D-Leu-Val-Tyr
-
-
?
thyrotropin + H2O
?
show the reaction diagram
-
-
-
-
?
Trypsinogen + H2O
?
show the reaction diagram
-
-
-
-
?
trypsinogen pro-peptide + H2O
?
show the reaction diagram
-
-
-
-
?
trypsinogen propeptide + H2O
?
show the reaction diagram
-
-
-
-
?
Tyr-Ala-4-nitroanilide + H2O
Tyr-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
Tyr-Ala-4-nitroanilide + H2O
Tyr-Ala + 4-nitroaniline
show the reaction diagram
-
poor substrate
-
?
Tyr-D-Ala-Gly-Phe-Met-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
Tyr-melanostatin + H2O
?
show the reaction diagram
-
-
-
-
?
Tyr-Pro-4-nitroanilide + H2O
Tyr-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Tyr-Pro-7-amido-4-methylcoumarin + H2O
Tyr-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Tyr-Pro-Phe + H2O
?
show the reaction diagram
-
-
-
-
?
Tyr-Pro-Phe-Pro + H2O
?
show the reaction diagram
-
-
-
-
?
Tyr-Pro-Phe-Pro-Gly + H2O
?
show the reaction diagram
-
-
-
-
?
Tyr-Pro-Phe-Pro-Gly-Pro-Ile + H2O
?
show the reaction diagram
Lactococcus lactis, Lactococcus lactis H1
-
-
-
-
?
Tyr-Pro-Phe-Pro-NH2 + H2O
Tyr-Pro + Phe-Pro-NH2
show the reaction diagram
-
i.e. morphiceptin
-
?
Val-Ala-4-nitroanilide + H2O
Val-Ala-4-nitroaniline
show the reaction diagram
-
-
-
-
?
Val-Ala-Ala-Phe + H2O
Val-Ala + Ala-Phe
show the reaction diagram
-
-
-
?
Val-Pro-4-nitroanilide + H2O
Val-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Val-Pro-4-nitroanilide + H2O
Val-Pro + 4-nitroaniline
show the reaction diagram
-
best substrate
-
?
Val-Pro-Leu + H2O
?
show the reaction diagram
-
-
-
-
?
Val-Pro-Leu + H2O
?
show the reaction diagram
-
83% of the activity with Gly-Pro-4-nitroanilide
-
-
?
vasostatin-1 + H2O
?
show the reaction diagram
-
-
-
-
?
VPAC2P-PEG + H2O
?
show the reaction diagram
-
VPAC2P-PEG is a VPAC2 receptor agonist peptide that acts as a glucose-dependent insulin secretagogue. Proteolysis by DPPIV may contribute to the in vivo clearance of VPAC2P-PEG. The N-terminus of VPAC2P-PEG is modified by N-terminal acetylation to impart DPPIV resistance. The acetylated peptide, Ac-VPAC2P-PEG, is a selective and potent VPAC2 agonist, resistant to DPPIV proteolysis
-
-
?
[Gly2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O
?
show the reaction diagram
-
GIP-fragment with glycine at position 2 in the sequence
-
?
[Ser2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O
?
show the reaction diagram
-
GIP-fragment with serine at position 2 in the sequence
-
?
[Ser2]glucose-dependent insulinotropic polypeptide(1-6) peptide + H2O
?
show the reaction diagram
-
GIP-fragment with serine at position 2 in the sequence
-
?
[Val2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O
?
show the reaction diagram
-
GIP-fragment with valine at position 2 in the sequence
-
?
monokine induced by IFN-gamma + H2O
?
show the reaction diagram
-
i.e. MIg or CXCL9, chemokine
-
?
additional information
?
-
-
-
-
-
-
additional information
?
-
-
substrate specificity
-
?
additional information
?
-
-
specifically recognized immobilized gelatin and type I collagen
-
-
-
additional information
?
-
-
peptides with proline penultimate to the amino terminus are more favored substrates while those substrates having Leu at both the penultimate position and amino terminus Leu-Leu
-
-
-
additional information
?
-
-
cleaves Gly-Pro from the N-terminal end of the fibrin alpha chain
-
-
-
additional information
?
-
-
specifically hydrolyzes N-terminal X-Pro from X-Pro-4-nitroanilides
-
-
-
additional information
?
-
-
use of fluorogenic rhodamine 110 (R110)-based substrates for the sensitive detection of DP IV on the surface of T cells
-
-
-
additional information
?
-
-
Ser624, Asp702, and His734 form the catalytic triad
-
-
-
additional information
?
-
-
specificity: specific for the S configuration of the amino-acid residue in P1 and P2 position if the penultimate residue is Pro, derivatives of Gly-Pro-4-nitroanilide where the N-terminal amino group is methylated are hydrolyzed
-
-
-
additional information
?
-
-
substrate specificty
-
?
additional information
?
-
-
substrate specificty
-
?
additional information
?
-
-
broad substrate specificity, structural elements of the substrate protein outside the immediate primary sequence of the cleavage site are crucial
-
?
additional information
?
-
-
enzyme binds adenosine deaminase at the highly glycosylated beta-propeller domain
-
?
additional information
?
-
-
enzyme binds to adenosine deaminase ADA
-
?
additional information
?
-
-
enzyme binds to adenosine deaminase, EC 3.5.4.4
-
?
additional information
?
-
-
enzyme binds to CD45 and to adenosine deaminase
-
?
additional information
?
-
-
larger compounds are cleaved with lower efficiency, importance of steric effects
-
?
additional information
?
-
-
LVV-hemorphin-7 and LVV-hemorphin-6 are no substrates for the enzyme
-
?
additional information
?
-
P22411
oligomerization state is important for interaction with other compounds, enzyme binds via Leu294 and Val341 to adenosine deaminase at T-cells, which is controlled by formation of a tetramer and glycosylation at Asn279
-
?
additional information
?
-
-
substrate specificity study, no activity with bradykinin, Pro-7-amido-4-methylcoumarin, benzyloxycarbonyl-Gly-Pro-7-amido-4-methylcoumarin, and benzyloxycarbonyl-Phe-Ala-7-amido-4-methylcoumarin
-
?
additional information
?
-
-
substrate specificity, enzyme binds adenosine deaminase
-
?
additional information
?
-
-
substrate specificity, positional scanning combinatorial dipeptide library profile shows that the enzyme is specific for Pro at P1 position and accepts a broad amino acid spectrum at P2 position with isoleucine and norleucine resulting in highest activity, norleucine-norleucine-rhodamine is no substrate, Gly-Ala-7-amido-4-methylcoumarin and Lys-Ala-7-amido-4-methylcoumarin are poor substrates
-
?
additional information
?
-
-
substrate specificty, no activity with glucose-dependent insulinotropic polypeptide(3-42) peptide, [Gly2]glucose-dependent insulinotropic polypeptide(1-6) peptide, and [Val2]glucose-dependent insulinotropic polypeptide(1-6) peptide
-
?
additional information
?
-
P27487
the enzyme binds with high affinity to adenosine deaminase, EC 3.5.4.4
-
?
additional information
?
-
O66223, -
the enzyme does not bind to adenosine deaminase, EC 3.5.4.4
-
?
additional information
?
-
-
on human T cells the enzyme has been demonstrated to be a functional collagen receptor leading to cell activation. The enzyme may be important in modulation of the biological activity on some of the cytokines, growth factors and neuropeptides. CD/DPP IV plays a role in HIV infection, but the exact mechanism remains to be elucidated
-
-
-
additional information
?
-
-
the enzyme participates in the catabolism of bradykinin and substance P as well as the post-translational processing of various other peptides
-
-
-
additional information
?
-
-
the enzyme may hinder blood coagulation in intact vessels in vivo, because it is located on the surface of the capillary endothelium
-
-
-
additional information
?
-
-
the enzyme may be involved in the initial phase of fibronectin-mediated cell spreading on collagen
-
-
-
additional information
?
-
-
possible role of the enzyme seems to match the high Pro content of beta-casein
-
-
-
additional information
?
-
-
the enzyme is an important constituent in the process of lymphocyte activation: The inhibition of dipeptidyl peptidase IV results in a supression of DNA synthesis and impairment of B cell differentiation and Ig synthesis of nitrogen-activated human lymphocytes
-
-
-
additional information
?
-
-
may play a role in cell attachment to collagen
-
-
-
additional information
?
-
-
obligatory role of the enzyme in renal handling of proline- and hydroxyproline-containing peptides
-
-
-
additional information
?
-
-
the enzyme plays a significant role in the process of activation and proliferation of human thymus-derived lymphocytes
-
-
-
additional information
?
-
-
binding of dipeptidyl peptidase IV to fibronectin may play a role in interaction of hepatocytes with extracellular matrix in vivo and possibly in matrix assembly
-
-
-
additional information
?
-
-
activity in glucose-containing medium remains constant during exponential growth and increases less than twofold when cells reach the stationary phase. Growth of yeast on poor nitrogen source or under nitrogen starvation results in a three- or fourfold increase in the level of the enzyme
-
-
-
additional information
?
-
-
binding of adenosine deaminase to the T-cell surface protects the T-cell from adenosine-mediated inhibition of proliferation
-
?
additional information
?
-
P27487
contributes to the regulation of various physiological processes, including blood sugar homeostasis, by cleaving peptide hormones, chemokines, and neuropeptides
-
?
additional information
?
-
-
enzyme has several purposes, e.g. as signaling molecule and adenosine deaminase binding protein, enzyme is involved in development of diverse diseases, overview
-
?
additional information
?
-
-
enzyme is implicated in several diseases
-
?
additional information
?
-
-
enzyme is important for metabolic regulation
-
?
additional information
?
-
-
enzyme is involved in diabetes mellitus, AIDS, and immunoregulatory processes
-
?
additional information
?
-
-
enzyme is involved in glucose metabolism in contributing to the regulation of glucagon family peptides
-
?
additional information
?
-
-
enzyme plays a key role in the regulation of differentiation and growth of lymphocytes
-
?
additional information
?
-
-
enzyme plays an important role in the activation and proliferation of lymphocytes
-
?
additional information
?
-
-
enzyme plays an important role in the process of activation and proliferation of lymphocytes, inhibition of the enzyme activity results in induction or mediation of diverse cellular processes and effects, such as induction of tyrosine phosphorylations, p38 MAP kinase activation, induction of TGF-beta1 secretion, suppression of DNA synthesis and proliferation, reduced production of various cytokines, and alteration anti-CD3-induced signalling pathways, overview
-
?
additional information
?
-
-
hemorphins may represent endogenous regulators of the enzyme activity
-
?
additional information
?
-
-
physiological function of enzyme activities with natural substrates, enzyme is involved in immune regulation, altered enzyme activity and expression level, and diverse physiological effects of increased enzyme expression, in cancer cells, overview, disregulation of the enzyme may contribute to cancer development
-
?
additional information
?
-
-
substrate specificity, cleavage of N-terminal dipeptide, no activity with vasoactive intestinal peptide, glucagon and secretin are poor substrates
-
?
additional information
?
-
-
the enzyme is supposed to mediate the immunosuppressive effects of HIV-1 Tat protein, enzyme plays a central role in signal transduction processes
-
?
additional information
?
-
-
DPP-IV influences pain perception via modulation of the peripheral concentration of substance P
-
-
-
additional information
?
-
Q96VT7
the enzyme is involved in protein maturation
-
-
-
additional information
?
-
-
the omega gene product is a modifier of larval cuticle protein 5 and its alleles in the third instar of Drosophila melanogaster
-
-
-
additional information
?
-
-
no hydrolysis of Ala-Ala-Pro-4-nitroanilide, Ala-Phe-Pro-4-nitroanilide, Pro-4-nitroanilide, Leu-4-nitroanilide, Arg, 4-nitroanilide, Ala-Ala-Ala-4-nitroanilide
-
-
-
additional information
?
-
-
CD26/DP IV is a nonredundant inhibitory receptor controlling T cell activation and Th1-mediated autoimmunity
-
-
-
additional information
?
-
-
dipeptidyl peptidase IV is the major enzyme responsible for degrading the incretins in vivo
-
-
-
additional information
?
-
-
DPP-4 is an important determinant of incretin inactivation
-
-
-
additional information
?
-
-
DPP-4 plays a role in the control of immune function, inflammatory responses, and behavior
-
-
-
additional information
?
-
-
enzyme plays a role in T cell activation
-
-
-
additional information
?
-
-
homodimeric DPP-IV interacts extracellularly with adenosine deaminase, and this interaction is critical for adenosine signaling and T-cell proliferation
-
-
-
additional information
?
-
-
kinetic characteristics of SADA (the catalytic subunit of adenosine deaminase), are modulated by the interaction with DPPIV-CD26 in favour of neutralization of toxic nucleosides (especially 2“-dAdo) in the extracellular medium
-
-
-
additional information
?
-
-
no endopeptidase or tripeptidase activity is detected for DPP9, tested against Z-Gly-L-Pro-p-nitroanilide, L-Ala-L-Ala-L-Ala-p-nitroanilide, and L-Ala-L-Ala-L-Pro-p-nitroanilide
-
-
-
additional information
?
-
-
dipeptidyl peptidase IV is a serine protease that cleaves X-Pro/Ala dipeptide from the N-terminus of proteins
-
-
-
additional information
?
-
-
DPP-IV typically cleaves Xaa-Pro or Xaa-Ala dipeptides from the N-terminus of peptides
-
-
-
additional information
?
-
-
XaaPro dipeptides linked to a free amino group present on an aromatic ring or on a sugar entity are prodrugs that efficiently release the parent drug upon conversion by DPPIV
-
-
-
additional information
?
-
-
the substrate specificity of DPP IV is not that strict and cleavage after the penultimate Ser, Gly, Thr, Val, and Leu has also been observed
-
-
-
additional information
?
-
Streptococcus salivarius HHT
-
specifically hydrolyzes N-terminal X-Pro from X-Pro-4-nitroanilides
-
-
-
additional information
?
-
Lactococcus lactis P8-2-47
-
possible role of the enzyme seems to match the high Pro content of beta-casein
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha1-microglobulin + H2O
?
show the reaction diagram
-
-
-
-
?
aprotinin + H2O
?
show the reaction diagram
-
-
-
-
?
beta-casomorphin + H2O
?
show the reaction diagram
-
-
-
-
?
beta-endorphin + H2O
?
show the reaction diagram
-
-
-
-
?
Bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
CCL11 + H2O
CCL11(3-74) + ?
show the reaction diagram
-
-
-
-
?
chemokines + H2O
?
show the reaction diagram
-
-
-
?
enterostatin + H2O
?
show the reaction diagram
-
-
-
-
?
eotaxin + H2O
?
show the reaction diagram
-
i.e. CCL11, chemokine
-
?
gastric inhibitory polypeptide + H2O
?
show the reaction diagram
-
-
-
-
?
gastrin releasing peptide + H2O
?
show the reaction diagram
-
-
-
-
?
gastrin releasing peptide + H2O
?
show the reaction diagram
-
sequential cleavage of 2 N-terminal peptides
-
?
gastrin releasing peptide-(1-27) + H2O
?
show the reaction diagram
-
i.e. GRP-(1-27), cleaves N-terminal dipeptide VP
-
ir
gastrin releasing peptide-(3-27) + H2O
?
show the reaction diagram
-
i.e. GRP-(3-27), cleaves N-terminal dipeptide LP
-
ir
gastrin-releasing peptide + H2O
?
show the reaction diagram
-
-
-
-
?
Glucagon + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 (7-36)-amide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 (7-37) + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
i.e. GLP 1
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
i.e. GLP-1, degradation, regulation of activity
-
ir
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
i.e. GLP-1, incretin, degradation, regulation of activity
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
i.e. GLP-1, degradation, regulation of activity, cleaves N-terminal dipeptide HA
-
ir
glucagon-like peptide 1 + H2O
?
show the reaction diagram
Mus musculus NOD/LtJ
-
-
-
-
?
glucagon-like peptide 2 (1-33) + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 2 + H2O
?
show the reaction diagram
-
i.e. GLP 2
-
?
glucagon-like peptide 2 + H2O
?
show the reaction diagram
-
i.e. GLP-1, degradation, regulation of activity, cleaves N-terminal dipeptide HA
-
ir
glucagon-like peptide-1 (7-36)-amide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide-1 + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide-1 + H2O
?
show the reaction diagram
-
dipeptidyl peptidase IV inactivates the hormone, thereby cancelling the prandial insulinotropic effect
-
-
?
glucagon-like peptide-1 + H2O
?
show the reaction diagram
-
dipeptidyl peptidase-IV is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1and glucose-dependent insulinotropic polypeptide
-
-
?
glucagon-like peptide-1 + H2O
?
show the reaction diagram
-
DPP-IV is the main proteolytic enzyme responsible for the rapid inactivation of glucagon-like peptide-1 into metabolites that are devoid of insulin-releasing activity
-
-
?
glucose-dependent insulinotropic peptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic peptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic peptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic peptide + H2O
?
show the reaction diagram
Mus musculus NOD/LtJ
-
-
-
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
i.e. GIP, incretin
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
i.e. GIP, cleaves N-terminal dipeptide YA
-
ir
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
dipeptidyl peptidase IV inactivates the hormone, thereby cancelling the prandial insulinotropic effect
-
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
dipeptidyl peptidase-IV is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1and glucose-dependent insulinotropic polypeptide
-
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
DPP-IV is the main proteolytic enzyme responsible for the rapid inactivation of glucose-dependent insulinotropic polypeptide into metabolites that are devoid of insulin-releasing activity
-
-
?
glucosedependent insulinotropic polypeptide + H2O
?
show the reaction diagram
-
-
-
-
?
Gly-Pro-glycinamide + H2O
?
show the reaction diagram
-
CD26 plays a direct regulatory and indispensable role in the eventual antiretroviral activity of small synthetic molecules such as the antiretroviral prodrug Gly-Pro-glycinamide
-
-
?
growth hormone releasing factor + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone releasing hormone (1-29) + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone releasing hormone (1-44) + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone releasing hormone-(1-29) fragment + H2O
?
show the reaction diagram
-
i.e. GHRH-(1-29), cleaves N-terminal dipeptide YA
-
ir
growth hormone releasing hormone-(1-44) fragment + H2O
?
show the reaction diagram
-
i.e. GHRH-(1-44), cleaves N-terminal dipeptide YA
-
ir
growth hormone-(1-43) fragment + H2O
?
show the reaction diagram
-
cleaves N-terminal dipeptide FP
-
ir
growth hormone-releasing hormone + H2O
?
show the reaction diagram
-
-
-
-
?
human chorionic gonadotropin alpha + H2O
?
show the reaction diagram
-
-
-
-
?
IFN-gamma-inducible protein 10 + H2O
?
show the reaction diagram
-
i.e. IP-10 or CXCL10, chemokine
-
?
IFN-inducible T-cell alpha-chemoattractant + H2O
?
show the reaction diagram
-
i.e. I-TAC or CXCL11, chemokine
-
?
incretin hormone + H2O
?
show the reaction diagram
-
-
-
ir
insulin-like growth factor-1 + H2O
?
show the reaction diagram
-
-
-
-
?
interferon-gamma-inducible protein-10 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin 1-beta + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-2 + H2O
?
show the reaction diagram
-
-
-
-
?
leutinising hormone alpha chain + H2O
?
show the reaction diagram
-
-
-
-
?
macrophage-derived chemokine + H2O
?
show the reaction diagram
-
-
-
-
?
macrophage-derived chemokine + H2O
?
show the reaction diagram
-
i.e. MDC or CCL22
-
?
monocyte chemotactic protein-1 + H2O
?
show the reaction diagram
-
-
-
-
?
monocyte chemotactic protein-2 + H2O
?
show the reaction diagram
-
-
-
-
?
neuropeptide Y + H2O
?
show the reaction diagram
-
-
-
-
?
neuropeptide Y + H2O
?
show the reaction diagram
-
-
-
-
?
neuropeptide Y + H2O
?
show the reaction diagram
-
-
-
-
?
NPY + H2O
?
show the reaction diagram
-
important step in the neuropeptide-Y NPY-mediated angiogenesis
-
?
oxyntomodulin + H2O
?
show the reaction diagram
-
cleaves N-terminal dipeptide HS
-
ir
peptide YY (1-36) + H2O
?
show the reaction diagram
-
-
-
-
?
peptide YY + H2O
?
show the reaction diagram
-
-
-
-
?
peptide YY + H2O
?
show the reaction diagram
-
-
-
-
?
peptide YY + H2O
peptide YY fragment 3-36
show the reaction diagram
-
high affinity substrate of DPP-IV
-
-
?
pituitary adenylate cyclase-activating polypeptide-(1-27) + H2O
?
show the reaction diagram
-
i.e. PACAP27, cleaves N-terminal dipeptide HS
-
?
pituitary adenylate cyclase-activating polypeptide-(1-38) + H2O
?
show the reaction diagram
-
i.e. PACAP38, enzyme plays a major role in the degradation of circulating PACAP38, cleaves N-terminal dipeptide HS
-
?
pro-colipase + H2O
?
show the reaction diagram
-
-
-
-
?
prolactin + H2O
?
show the reaction diagram
-
-
-
-
?
promastoparan + H2O
mastoparan + ?
show the reaction diagram
-
-
-
-
?
RANTES + H2O
?
show the reaction diagram
-
i.e. CCL5 or regulated on activation normal T-cell expressed and secreted, chemokine
-
?
RANTES protein + H2O
?
show the reaction diagram
-
-
-
-
?
SDF-1/CXCL12 + H2O
?
show the reaction diagram
-
CD26 may play a role in SDF-1/CXCL12 mediated functions such as chemotaxis
-
-
?
stromal cell derived factor 1 + H2O
?
show the reaction diagram
-
i.e. SDF-1 or CXCL12, chemokine
-
?
stromal cell-derived factor 1alpha + H2O
?
show the reaction diagram
-
-
-
-
?
stromal cell-derived factor 1beta + H2O
?
show the reaction diagram
-
-
-
-
?
stromal cell-derived factor-1 + H2O
?
show the reaction diagram
-
-
-
-
?
Substance P + H2O
?
show the reaction diagram
-
-
-
-
?
substance P + H2O
peptides SP(3-11) + SP(5-11)
show the reaction diagram
-
i.e. SP, sequential cleavage of full length substance P
both fragments are still active
?
thyrotropin + H2O
?
show the reaction diagram
-
-
-
-
?
Trypsinogen + H2O
?
show the reaction diagram
-
-
-
-
?
trypsinogen pro-peptide + H2O
?
show the reaction diagram
-
-
-
-
?
vasostatin-1 + H2O
?
show the reaction diagram
-
-
-
-
?
monokine induced by IFN-gamma + H2O
?
show the reaction diagram
-
i.e. MIg or CXCL9, chemokine
-
?
additional information
?
-
-
-
-
-
-
additional information
?
-
-
substrate specificty
-
?
additional information
?
-
-
on human T cells the enzyme has been demonstrated to be a functional collagen receptor leading to cell activation. The enzyme may be important in modulation of the biological activity on some of the cytokines, growth factors and neuropeptides. CD/DPP IV plays a role in HIV infection, but the exact mechanism remains to be elucidated
-
-
-
additional information
?
-
-
the enzyme participates in the catabolism of bradykinin and substance P as well as the post-translational processing of various other peptides
-
-
-
additional information
?
-
-
the enzyme may hinder blood coagulation in intact vessels in vivo, because it is located on the surface of the capillary endothelium
-
-
-
additional information
?
-
-
the enzyme may be involved in the initial phase of fibronectin-mediated cell spreading on collagen
-
-
-
additional information
?
-
-
possible role of the enzyme seems to match the high Pro content of beta-casein
-
-
-
additional information
?
-
-
the enzyme is an important constituent in the process of lymphocyte activation: The inhibition of dipeptidyl peptidase IV results in a supression of DNA synthesis and impairment of B cell differentiation and Ig synthesis of nitrogen-activated human lymphocytes
-
-
-
additional information
?
-
-
may play a role in cell attachment to collagen
-
-
-
additional information
?
-
-
obligatory role of the enzyme in renal handling of proline- and hydroxyproline-containing peptides
-
-
-
additional information
?
-
-
the enzyme plays a significant role in the process of activation and proliferation of human thymus-derived lymphocytes
-
-
-
additional information
?
-
-
binding of dipeptidyl peptidase IV to fibronectin may play a role in interaction of hepatocytes with extracellular matrix in vivo and possibly in matrix assembly
-
-
-
additional information
?
-
-
activity in glucose-containing medium remains constant during exponential growth and increases less than twofold when cells reach the stationary phase. Growth of yeast on poor nitrogen source or under nitrogen starvation results in a three- or fourfold increase in the level of the enzyme
-
-
-
additional information
?
-
-
binding of adenosine deaminase to the T-cell surface protects the T-cell from adenosine-mediated inhibition of proliferation
-
?
additional information
?
-
P27487
contributes to the regulation of various physiological processes, including blood sugar homeostasis, by cleaving peptide hormones, chemokines, and neuropeptides
-
?
additional information
?
-
-
enzyme has several purposes, e.g. as signaling molecule and adenosine deaminase binding protein, enzyme is involved in development of diverse diseases, overview
-
?
additional information
?
-
-
enzyme is implicated in several diseases
-
?
additional information
?
-
-
enzyme is important for metabolic regulation
-
?
additional information
?
-
-
enzyme is involved in diabetes mellitus, AIDS, and immunoregulatory processes
-
?
additional information
?
-
-
enzyme is involved in glucose metabolism in contributing to the regulation of glucagon family peptides
-
?
additional information
?
-
-
enzyme plays a key role in the regulation of differentiation and growth of lymphocytes
-
?
additional information
?
-
-
enzyme plays an important role in the activation and proliferation of lymphocytes
-
?
additional information
?
-
-
enzyme plays an important role in the process of activation and proliferation of lymphocytes, inhibition of the enzyme activity results in induction or mediation of diverse cellular processes and effects, such as induction of tyrosine phosphorylations, p38 MAP kinase activation, induction of TGF-beta1 secretion, suppression of DNA synthesis and proliferation, reduced production of various cytokines, and alteration anti-CD3-induced signalling pathways, overview
-
?
additional information
?
-
-
hemorphins may represent endogenous regulators of the enzyme activity
-
?
additional information
?
-
-
physiological function of enzyme activities with natural substrates, enzyme is involved in immune regulation, altered enzyme activity and expression level, and diverse physiological effects of increased enzyme expression, in cancer cells, overview, disregulation of the enzyme may contribute to cancer development
-
?
additional information
?
-
-
substrate specificity, cleavage of N-terminal dipeptide, no activity with vasoactive intestinal peptide, glucagon and secretin are poor substrates
-
?
additional information
?
-
-
the enzyme is supposed to mediate the immunosuppressive effects of HIV-1 Tat protein, enzyme plays a central role in signal transduction processes
-
?
additional information
?
-
-
DPP-IV influences pain perception via modulation of the peripheral concentration of substance P
-
-
-
additional information
?
-
Q96VT7
the enzyme is involved in protein maturation
-
-
-
additional information
?
-
-
the omega gene product is a modifier of larval cuticle protein 5 and its alleles in the third instar of Drosophila melanogaster
-
-
-
additional information
?
-
-
CD26/DP IV is a nonredundant inhibitory receptor controlling T cell activation and Th1-mediated autoimmunity
-
-
-
additional information
?
-
-
dipeptidyl peptidase IV is the major enzyme responsible for degrading the incretins in vivo
-
-
-
additional information
?
-
-
DPP-4 is an important determinant of incretin inactivation
-
-
-
additional information
?
-
-
DPP-4 plays a role in the control of immune function, inflammatory responses, and behavior
-
-
-
additional information
?
-
-
enzyme plays a role in T cell activation
-
-
-
additional information
?
-
-
homodimeric DPP-IV interacts extracellularly with adenosine deaminase, and this interaction is critical for adenosine signaling and T-cell proliferation
-
-
-
additional information
?
-
-
dipeptidyl peptidase IV is a serine protease that cleaves X-Pro/Ala dipeptide from the N-terminus of proteins
-
-
-
additional information
?
-
-
DPP-IV typically cleaves Xaa-Pro or Xaa-Ala dipeptides from the N-terminus of peptides
-
-
-
additional information
?
-
-
XaaPro dipeptides linked to a free amino group present on an aromatic ring or on a sugar entity are prodrugs that efficiently release the parent drug upon conversion by DPPIV
-
-
-
additional information
?
-
Lactococcus lactis P8-2-47
-
possible role of the enzyme seems to match the high Pro content of beta-casein
-
-
-
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Ca2+
-
0.1-2.5 mM, activates
Fe2+
-
slight increase in activity
K+
-
10-50 mM, activates
Mg2+
-
2.5 mM, activates
Mg2+
-
1.0 mM, 7% activation
Na+
-
10-50 mM, activates
Mn2+
-
slight increase in activity
additional information
-
not affected by various cations
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
(11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(1R)-1-(4-bromophenyl)-2-(2,5-difluorophenyl)ethanamine
-
-
(1R)-1-[4-(3-chloropyridin-4-yl)phenyl]-2-(2,5-difluorophenyl)ethanamine
-
-
(1R)-2-(2,5-difluorophenyl)-1-(4-pyridin-4-ylphenyl)ethanamine
-
-
(1R)-2-([(3R,4R)-4-amino-1-[1-(4-ethynylphenyl)ethyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile
-
-
(1R)-2-([(3R,4R)-4-amino-1-[2-methyl-4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile
-
-
(1R)-2-([(3R,4R)-4-amino-1-[3-methyl-4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile
-
-
(1R)-2-[[(3R,4R)-4-amino-1-(3,4-dihydro-2H-chromen-4-yl)pyrrolidin-3-yl]carbonyl]cyclopentanecarbonitrile
-
-
(1R)-2-[[(3R,4R)-4-amino-1-[1-[4-(1H-1,2,4-triazol-1-yl)phenyl]ethyl]pyrrolidin-3-yl]carbonyl]cyclopentanecarbonitrile
-
-
(1R,2S)-1-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-3-cyclopentylidene-1-cyclopropyl-3-fluoropropan-2-aminium
-
-
(1R,3S)-2-([(3R,4R)-4-amino-1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)-3-fluorocyclopentanecarbonitrile
-
-
(1R,3S)-2-[(2S)-2-amino-2-cyclopentylacetyl]-3-ethynylcyclopentanecarbonitrile
-
-
(1S)-1-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethanaminium
-
-
(1S)-1-cyclohexyl-2-(3,3-difluoropyrrolidin-1-yl)-2-oxoethanamine
-
-
(1S)-1-cyclohexyl-2-(3-fluoropyrrolidin-1-yl)-2-oxoethanamine
-
-
(1S)-1-cyclohexyl-2-oxo-2-(3,3,4,4-tetrafluoropyrrolidin-1-yl)ethanamine
-
-
(1S,2R)-1-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-3-cyclopentylidene-1-cyclopropyl-3-fluoropropan-2-aminium
-
-
(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)cyclohexanamine
-
the inhibitor has similar potency to sitagliptin and excellent pharmacokinetic properties
(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)cyclohexanamine
-
-
(1S,2S)-1-(4'-fluorobiphenyl-4-yl)-3-[(3S)-3-fluoropyrrolidin-1-yl]-3-oxo-1-(1H-tetrazol-1-yl)propan-2-amine
-
-
(1S,2S)-1-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-cyclopropyl-3-[(3S)-3-fluoropyrrolidin-1-yl]-3-oxopropan-2-aminium
-
-
(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
-
-
(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
-
-
(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
-
66% plasma DPP-IV inhibition after 30 min at 3 mg/kg oral dose, 30% plasma DPP-IV inhibition after 8 h at 3 mg/kg oral dose
(1S,3S,5S)-2-[(2S)-2-amino-2-[(1R,3S,5S)-3-hydroxytricyclo[3.3.1.13,7]dec-1-yl]acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
-
-
(2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridine carboxylic acid
-
i. e. ABT-279, a very potent, selective, effective, and well-tolerated inhibitor useful for the treatment of diabetes
(2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridinecarboxylic acid
-
i. e. ABT-279, a very potent, selective, effective, and well-tolerated inhibitor useful for the treatment of diabetes
(2R)-1-(2,4-dichlorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(2,4-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(2,4-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(2,5-dichlorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-(2-phenyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)butan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-(3-pyridin-4-yl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-[2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-[(4R)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-[(4S)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-[1-(2-methylpropyl)-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-[1-(4-fluorobenzyl)-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-[1-ethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-[1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-[2-(4-fluorophenyl)-1-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-[3-(2,5-difluorophenyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxobutan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-[3-(2-methylpropyl)-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-[3-(4-fluorobenzyl)-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-[3-(4-fluorophenyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxobutan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-[3-ethyl-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-[3-methyl-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxobutan-2-amine
-
-
(2R)-1-(2-chloro-4,5-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(2-chlorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(2-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(2-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(2-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(2-methylphenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(3,4-dichlorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(3,4-dichlorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(3,4-difluorophenyl)-4-(3-ethyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-oxobutan-2-amine
-
-
(2R)-1-(3,4-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(3,4-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(3,4-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(3-chlorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(3-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(3-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(4-chloro-2,5-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(4-chlorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(4-chlorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(4-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(4-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(4-iodophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(4-nitrophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(5-chloro-2-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-cyclohexyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium
-
-
(2R)-1-[8-(trifluoromethyl)bis[1,2,4]triazolo[4,3-a:3',4'-c]pyrazin-3-yl]-3-(2,4,5-trifluorophenyl)propan-2-amine
-
-
(2R)-1-[9-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4',3':1,2]pyrido[3,4-d]pyrimidin-3-yl]-3-(2,4,5-trifluorophenyl)propan-2-amine
-
-
(2R)-1-[N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2R)-4-(1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(2-benzoylpyrazolidin-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(2-cyclopropyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(3-cyclopropyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(3-ethyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(3-methyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(4-acetyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(4-benzyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(4-ethyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-1-(2,4,5-trifluorophenyl)-4-[1,4,4-trimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-2-amine
-
-
(2R)-4-oxo-1-(pentafluorophenyl)-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-4-oxo-1-phenyl-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-4-oxo-1-pyridin-2-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-4-oxo-1-pyridin-3-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-4-oxo-1-pyridin-4-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-(3,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[2-(trifluoromethyl)phenyl]butan-2-amine
-
-
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[3-(trifluoromethyl)phenyl]butan-2-amine
-
-
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[4-(trifluoromethyl)phenyl]butan-2-amine
-
-
(2R)-4-oxo-4-(2-phenyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-(4-pyrazin-2-yl-1,4-diazepan-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-(4-pyrimidin-2-yl-1,4-diazepan-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-pyrazolidin-1-yl-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[(8R)-2-(trifluoromethyl)-8-[4-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[(8R)-3-(trifluoromethyl)-8-[2-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[(8R)-8-(1H-1,2,4-triazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[(8R)-8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[(8R)-8-(pyridin-2-ylmethyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[(8R)-8-prop-2-en-1-yl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[(8S)-3-(trifluoromethyl)-8-[2-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[(8S)-8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[(8S)-8-(pyridin-2-ylmethyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[(8S)-8-prop-2-en-1-yl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[2-(phenylcarbonyl)-1,2-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
competitive
(2R)-4-oxo-4-[2-(phenylcarbonyl)tetrahydropyridazin-1(2H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
the inhibitor displays a greater than 1400fold selectivity over all the enzymes tested including DPP-8 and DPP-9
(2R)-4-oxo-4-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,3,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,3,6-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
sitagliptin
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,6-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-[2-(trifluoromethyl)phenyl]butan-2-amine
-
-
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-[3-(trifluoromethyl)phenyl]butan-2-amine
-
-
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-[4-(trifluoromethyl)phenyl]butan-2-amine
-
-
(2R)-4-oxo-4-[4-(phenylcarbonyl)-1,4-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[4-(pyridin-3-ylcarbonyl)-1,4-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[8-(1H-pyrazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(2R)-2-benzylpiperazin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(4R)-1-methyl-4-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(4R)-2-cyclopropyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(4R)-2-tert-butyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(4R)-4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(4R)-4-benzyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(4R)-4-cyclopropyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(4R)-4-ethyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(4S)-1-methyl-4-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(4S)-2-cyclopropyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(4S)-2-tert-butyl-1,4-dimethyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(4S)-4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(4S)-4-benzyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(4S)-4-cyclopropyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(4S)-4-ethyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(5R)-5-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(5S)-5-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(6R)-6-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(6S)-6-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-(2-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-(4-methoxybenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-(cyclopropylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-benzyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-ethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-[(1-fluorocyclopropyl)methyl]-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-[3,5-bis(trifluoromethyl)benzyl]-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8S)-8-(2-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8S)-8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8S)-8-(4-methoxybenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8S)-8-benzyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8S)-8-ethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8S)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8S)-8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8S)-8-[3,5-bis(trifluoromethyl)benzyl]-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[2-[(4-methylphenyl)sulfonyl]pyrazolidin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[3-(difluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[4-(1,3-benzodioxol-5-ylcarbonyl)-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine hydrochloride
-
-
(2R)-4-[4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[4-(methylsulfonyl)-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[4-[(4-methylphenyl)sulfonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[4-[(4-methylpiperazin-1-yl)carbonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[4-[(4-nitrophenyl)sulfonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[5,5-dimethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8,8-dimethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8-(1H-imidazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R,3R)-1-(2,5-difluorophenyl)-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-amine
-
-
(2R,3R)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
-
potent, selectiveDPP-4 inhibitor
(2R,3R)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R,3R)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R,3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
-
-
(2R,3S)-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N1,N1-dimethyl-4-oxobutane-1,3-diamine
-
-
(2R,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluoro-5-hydroxypentan-2-aminium
-
-
(2R,3S,11bS)-3-(3,4-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-(4-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-pyridin-2-yl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,5R)-5-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine
-
-
(2R,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
-
-
(2R,4R)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
-
-
(2R,4R)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
-
-
(2R,4S)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
-
-
(2R,4S)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
-
-
(2R,5S)-1-[N-[1-(5-cyanopyridin-2-yl)-4-methylpiperidin-4-yl]glycyl]pyrrolidine-2,5-dicarbonitrile
-
-
(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)-N-phenylpyrrolidine-2-carboxamide
-
-
(2R,5S)-N-(4-bromophenyl)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidine-2-carboxamide
-
-
(2S)-1-(((2S,5R)-5-[(1,3-benzodioxol-4-yloxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(1-naphthyloxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(2,4-dichlorophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(2,6-dichlorophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(2-chloro-4-cyanophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(2-chlorophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(2-methylphenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(4-bromophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(4-cyanophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(4-methoxyphenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(4-methylphenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(benzyloxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(3-furyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2S)-1-(5-morpholin-4-yl-5-oxo-L-norvalyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(5-oxo-5-piperidin-1-yl-L-norvalyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(5-oxo-5-pyrrolidin-1-yl-L-norvalyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,4S)-4-[(2E)-but-2-en-1-yl]pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,4S)-4-[(3-chloro-4-cyanophenyl)amino]pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-(([2-chloro-5-(dihydroxymethyl)pyridin-3-yl]oxy)methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-(([dihydroxy(phenyl)-'4-sulfanyl]amino)methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-(anilinomethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-(morpholin-4-ylmethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-(phenoxymethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-([(2-chloropyridin-3-yl)oxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-([(4-bromophenyl)amino]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-([(6-bromo-1,3-benzodioxol-5-yl)oxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-([2,4-dichloro-5-(dihydroxyamino)phenoxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-([2-bromo-4-(methylsulfonodithioyl)phenoxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-([2-chloro-4-(methylsulfonodithioyl)phenoxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(1,2,3-thiadiazol-4-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(1-methyl-1H-pyrazol-4-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(1H-pyrazol-5-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(2H-1,2,3-triazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(3-methyl-1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([[(1R,3S,5S)-3-hydroxytricyclo[3.3.1.13,7]dec-1-yl]amino]acetyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([[2-methyl-4-oxo-4-(pyrrolidin-1-yl)butan-2-yl]amino]acetyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-cyclopentyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2S)-1-L-prolylpyrrolidine-2-carbonitrile
-
IC50: 2.9 nmol/L
(2S)-1-[(1-adamantylamino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-1-oxo-3-phenylpropan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-1-oxohexan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3,3-dimethyl-1-oxobutan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-(4-chlorophenyl)-1-oxopropan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-methyl-1-oxobutan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-4-methyl-3-(1-methylethyl)-1-oxopentan-2-amine
-
-
(2S)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium
-
-
(2S)-1-[(2R)-2-amino-2-cyclopentylacetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(2S)-2-amino-2-cyclopentylacetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(2S)-2-amino-4-(1,3-dihydro-2H-isoindol-2-yl)-4-oxobutanoyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(2S)-2-amino-6-(1,3-dihydro-2H-isoindol-2-yl)-6-oxohexanoyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(2S,3R)-2-amino-3-ethyl-5-oxo-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]pentanoyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(2S,3S)-2-amino-3-methylpentanoyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2S)-1-[(4R)-4-tricyclo[3.3.1.13,7]dec-2-yl-L-prolyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(4S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5,5-dimethyl-L-prolyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(4S)-4-(azocan-1-ylcarbonyl)-L-prolyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(cyclopentylamino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(tert-butylamino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[([2-[(5-nitropyridin-2-yl)amino]ethyl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[([4-[(3R)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[3-([2-[(5-nitropyridin-2-yl)amino]ethyl]amino)propanoyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[3-methyl-5-oxo-5-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-L-alloisoleucyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[3-methyl-5-oxo-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-L-alloisoleucyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[3-methyl-5-[(2R)-2-methylpyrrolidin-1-yl]-5-oxo-L-alloisoleucyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-(1,3-dihydro-2H-isoindol-2-yl)-3-methyl-5-oxo-L-alloisoleucyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-(1,3-dihydro-2H-isoindol-2-yl)-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-(3,4-dihydroisoquinolin-2(1H)-yl)-3-methyl-5-oxo-L-alloisoleucyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-(3,4-dihydroisoquinolin-2(1H)-yl)-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-(4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl)-3-methyl-5-oxo-L-alloisoleucyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-(4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl)-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-oxo-5-(1,3-thiazolidin-3-yl)-L-norvalyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-oxo-5-(4-pyridin-4-ylpiperazin-1-yl)-L-norvalyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-oxo-5-[2-(trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]-L-norvalyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-oxo-5-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-L-norvalyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-oxo-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-L-alloisoleucyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-oxo-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-L-norvalyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-oxo-5-[4-(trifluoroacetyl)piperazin-1-yl]-L-norvalyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-[(2R)-2-(methoxyamino)pyrrolidin-1-yl]-3-methyl-5-oxo-L-alloisoleucyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-[2-(4-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl]-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[5-[6,7-dimethoxy-1-(1-methylethyl)-3,4-dihydroisoquinolin-2(1H)-yl]-5-oxo-L-norvalyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[N-[3-(1,3-dihydro-2H-isoindol-2-yl)-1,1-dimethyl-3-oxopropyl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[N-[4-(1,3-dihydro-2H-isoindol-2-yl)-2-methyl-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(1R,3S,5R,7R)-tricyclo[3.3.1.13,7]dec-2-ylamino]acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(1R,5R)-tricyclo[3.3.1.13,7]dec-2-ylamino]acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(2-ethyl-4-hydroxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(2-hydroxyethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(2-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(3-hydroxy-2,4,6-trimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(3-hydroxy-2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(3-hydroxy-2-methoxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(3-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(4-hydroxy-2,6-dimethoxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(4-hydroxy-2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(4-hydroxy-2-methoxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(4-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-cyclohexylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-phenylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
in vivo plasma DPP-IV inhibition in Wistar rats
(2S)-1-[[(2S,4S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(azepan-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(azetidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(hydroxymethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-allylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-isobutylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-phenylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-propylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-4-(azetidin-1-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile
-
84% plasma DPP-IV inhibition after 30 min at 3 mg/kg oral dose, 73% plasma DPP-IV inhibition after 8 h at 3 mg/kg oral dose
(2S)-1-[[(3R,4R)-4-amino-1-(3-cyano-4-fluorobenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3R,4R)-4-amino-1-(4-cyano-3-methylbenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3R,4R)-4-amino-1-(4-cyanobenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3R,4R)-4-amino-1-(quinolin-3-ylmethyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-2-(1-adamantyl)-2-amino-N-(1-cyanoethyl)acetamide
-
-
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-cyclopropylacetamide
-
-
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-ethylacetamide
-
-
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-methylacetamide
-
-
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-propylacetamide
-
-
(2S)-2-(1-adamantyl)-N-allyl-2-amino-N-(cyanomethyl)acetamide
-
-
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2,5-difluoro-4-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
-
-
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
-
-
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-5-(trifluoromethoxy)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
-
-
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-5-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
-
-
(2S)-2-(4-[[([(4R)-3-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)-3-methylbutanoic acid
-
-
(2S)-2-amino-N-(1-cyanoethyl)-3,3-dimethylbutanamide
-
-
(2S)-2-amino-N-(1-cyanoethyl)-N,3,3-trimethylbutanamide
-
-
(2S)-2-amino-N-(cyanomethyl)-2-(3,5-dihydroxy-1-adamantyl)-N-methylacetamide
-
-
(2S)-2-amino-N-(cyanomethyl)-2-(3-hydroxy-1-adamantyl)-N-methylacetamide
-
-
(2S)-2-amino-N-(cyanomethyl)-N,3,3-trimethylbutanamide
-
-
(2S)-2-amino-N-(cyanomethyl)-N,3-dimethylbutanamide
-
-
(2S)-2-amino-N-(cyanomethyl)-N-cyclobutyl-3,3-dimethylbutanamide
-
-
(2S)-2-amino-N-(cyanomethyl)-N-cyclopropyl-3,3-dimethylbutanamide
-
-
(2S)-2-amino-N-(cyanomethyl)-N-ethyl-2-(3-hydroxy-1-adamantyl)acetamide
-
-
(2S)-2-amino-N-(cyanomethyl)-N-ethyl-3,3-dimethylbutanamide
-
-
(2S)-2-[2-[([1-[(2S)-2-amino-2-cyclohexylacetyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(2,5-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-chloro-4-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]propanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(3,4-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(5-chloro-2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(5-fluoro-2-methylphenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(pentafluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-phenylbutanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxopropan-2-amine
-
-
(2S)-3-methyl-1-oxo-1-pyrrolidin-1-ylbutan-2-amine
-
-
(2S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluoropropan-2-aminium
-
-
(2S)-5-(1,3-dihydro-2H-isoindol-2-yl)-1,5-dioxo-1-(1,3-thiazolidin-3-yl)pentan-2-amine
-
-
(2S)-N-allyl-2-amino-N-(cyanomethyl)-3,3-dimethylbutanamide
-
-
(2S)-{((3-Hydroxyadamantan-1-yl)amino) acetyl}pyrrolidin-2-carbonitrile
-
vldagliptin is rapidly and well absorbed with an estimated absolute bioavailability of 85%. Two possible sites of absorption are identified, and the absorption rates are slower than the elimination rate, indicating a flip-flop phenomenon after oral dosing
(2S,3R)-1-cyclopentylidene-1-fluoro-3-(3-[4-[(trifluoromethyl)sulfonyl]phenyl]-1,2,4-oxadiazol-5-yl)butan-2-aminium
-
-
(2S,3R)-1-cyclopentylidene-1-fluoro-3-[3-[4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-aminium
-
-
(2S,3R)-1-cyclopentylidene-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-fluorobutan-2-aminium
-
-
(2S,3R)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-methyl-1-oxopentan-2-amine
-
-
(2S,3R)-3-(3-[2-chloro-4-[(methylsulfonyl)amino]phenyl]-1,2,4-oxadiazol-5-yl)-1-cyclopentylidene-1-fluorobutan-2-aminium
-
-
(2S,3R)-3-[3-(4-bromo-2-chlorophenyl)-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluorobutan-2-aminium
-
-
(2S,3R)-3-[3-[2-chloro-4-(ethylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluorobutan-2-aminium
-
-
(2S,3R)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluoro-5-hydroxypentan-2-aminium
-
-
(2S,3R)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluorobutan-2-aminium
-
-
(2S,3R)-3-[3-[2-chloro-4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluorobutan-2-aminium
-
-
(2S,3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
-
-
(2S,3S)-1-oxo-1-pyrrolidin-1-yl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-(4-pyridin-4-ylphenyl)butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-phenylbutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[2'-(trifluoromethyl)biphenyl-4-yl]butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-1,2,4-triazol-3-yl)biphenyl-4-yl]butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-tetrazol-1-yl)biphenyl-4-yl]butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-tetrazol-5-yl)biphenyl-4-yl]butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4'-(trifluoromethyl)biphenyl-4-yl]butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4-(trifluoromethyl)phenyl]butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino)cyclohexyl]butan-2-aminium
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(2'-methoxybiphenyl-4-yl)-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(2'-methylbiphenyl-4-yl)-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4'-methoxybiphenyl-4-yl)-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4'-methylbiphenyl-4-yl)-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-methoxyphenyl)-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[[(4-methoxyphenyl)carbonyl](methyl)amino]cyclohexyl)-1-oxobutan-2-aminium
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[[(4-methoxyphenyl)carbonyl]amino]cyclohexyl)-1-oxobutan-2-aminium
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3'-(1,3,4-oxadiazol-2-yl)biphenyl-4-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3'-(methylsulfonyl)biphenyl-4-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4'-(methylsulfonyl)biphenyl-4-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(methylthio)phenyl]-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-fluoro-2-(trifluoromethyl)phenyl]-1-oxobutan-2-amine
-
-
(2S,3S)-2-amino-1-((1S,5S)-2-azabicyclo[3.1.0]hexan-2-yl)-3-methylpentan-1-one
-
-
(2S,3S)-2-amino-3-methyl-1-(thiazolidin-3-yl)pentan-1-one
-
-
(2S,3S)-3-(2',4'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(2',5'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(2'-chlorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(2'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(2,4-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(2-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(3',4'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(3',5'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(3,4-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(3,5-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(3-chloro-4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(3-chlorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(3-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-4-pyrrolidin-1-ylbutan-2-amine
-
-
(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-5-pyrrolidin-1-ylpentan-2-amine
-
-
(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-(4-bromophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(4-chloro-2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-3-(4-[[(4-fluorophenyl)carbonyl](methyl)amino]phenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-amino-2-(2',4'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(2',5'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(3',4'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(3'-ethynylbiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3R)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-1-ol
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoic acid
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N',N'-dimethyl-4-oxobutanehydrazide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-(1-methylethyl)-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-(2-hydroxyethyl)-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methoxy-N-methyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-morpholin-4-yl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-(1,3-thiazolidin-3-yl)butanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-piperidin-1-ylbutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide
-
-
(2S,3S)-3-amino-4-(1,1-dioxido-1,3-thiazolidin-3-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-4-(3,3-difluoroazetidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide
-
a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)butanamide
-
-
(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(trans-4-[1,2,4]triazolo[1,5-a]pyridin-6-ylcyclohexyl)butanamide
-
-
(2S,3S)-3-amino-4-(3-fluoroazetidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-4-aziridin-1-yl-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-4-oxobutanamide
-
-
(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyridin-3-ylphenyl)butanamide
-
-
(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyridin-4-ylphenyl)butanamide
-
-
(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[3'-(2H-tetrazol-2-yl)biphenyl-4-yl]butanamide
-
-
(2S,3S)-3-amino-N,N-diethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
-
-
(2S,3S)-3-amino-N-(3,4-dihydro-2H-tetrazol-2-yl)-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
-
-
(2S,3S)-3-amino-N-cyclopropyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
-
-
(2S,3S)-3-amino-N-ethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
-
-
(2S,3S)-3-amino-N-ethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methyl-4-oxobutanamide
-
-
(2S,3S)-3-biphenyl-4-yl-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-methyl-1-oxo-1-(1,3-thiazolidin-3-yl)pentan-2-amine
-
-
(2S,3S)-3-methyl-1-oxo-1-pyrrolidin-1-ylpentan-2-amine
-
-
(2S,3S)-3-[3'-(5-cyclopropyl-2,3-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-oxo-1-pyrrolidin-1-ylbutan-2-aminium
-
-
(2S,3S)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-oxo-1-pyrrolidin-1-ylbutan-2-aminium
-
-
(2S,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-5-hydroxy-1-oxopentan-2-aminium
-
-
(2S,3S)-3-[3-[4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-oxo-1-pyrrolidin-1-ylbutan-2-aminium
-
-
(2S,3S)-3-[4-(3-chloropyridin-4-yl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-[4-(acetylamino)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-[4-[(cyclopropylcarbonyl)(methyl)amino]cyclohexyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-[4-[acetyl(methyl)amino]cyclohexyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-[4-[acetyl(methyl)amino]cyclohexyl]-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-3-[4-[acetyl(methyl)amino]phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-[4-[acetyl(methyl)amino]phenyl]-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-3-[4-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino)cyclohexyl]butan-2-aminium
-
-
(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-3-[4-[(phenylsulfonyl)amino]phenyl]butan-2-aminium
-
-
(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[methyl[(4-methylphenyl)carbonyl]amino]phenyl)-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[methyl[(4-methylphenyl)sulfonyl]amino]phenyl)-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-4-(dimethylamino)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-4-(dimethylamino)-3-(4-[[(3-fluorophenyl)carbonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-4-(dimethylamino)-3-(4-[[(4-fluorophenyl)carbonyl](methyl)amino]phenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-4-azetidin-1-yl-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-amine
-
-
(2S,3S)-4-cyclopropyl-3-[3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-(1,1-dioxido-1,2-thiazinan-2-yl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-(2,5-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-(3,4-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-(3-cyclopropylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-(3-ethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-butyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-pyrido[2,1-a]isoquinoline-2,11b-diamine
-
-
(2S,3S,11bS)-3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-[3-(fluoromethyl)phenyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-[4-(fluoromethyl)pyridin-2-yl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-(4-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-(4-methylpyridin-2-yl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-pyridin-2-yl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-[3-(propan-2-yl)phenyl]-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-2-ethyl-N,N-dimethylpyrrolidine-3-carboxamide
-
-
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
-
-
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N,2-dimethylpyrrolidine-3-carboxamide
-
-
(2S,4R)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
-
-
(2S,4R)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-((2S)-2-amino-3-methylpentanoyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-1-adamantylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-2-adamantylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-cyclobutylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-cyclooctylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-cyclopentylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-cyclopropylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-[2-[(5-chloropyridin-2-yl)amino]ethyl]-glycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(O-benzyl-L-threonyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-L-alloisoleucyl-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile
-
potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV
(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile
-
potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV, 82% plasma DPP-IV inhibition after 30 min at 3 mg/kg oral dose, 70% plasma DPP-IV inhibition after 8 h at 3 mg/kg oral dose
(2S,4S)-1-[N-(tert-butyl)glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[(2E)-1,1-dimethyl-3-phenylprop-2-en-1-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[1-(1-benzofuran-2-yl)-1-methylethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[2-(3,4-dimethoxyphenyl)ethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[2-(diethylamino)-1,1-dimethylethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[4-(3,6-dihydropyridin-1(2H)-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[4-(3,6-dihydropyridin-1(2H)-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
85% plasma DPP-IV inhibition after 30 min at 3 mg/kg oral dose, 70% plasma DPP-IV inhibition after 8 h at 3 mg/kg oral dose
(2S,4S)-1-[N-[4-(7-azabicyclo[2.2.1]hept-7-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[4-(azepan-1-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[O-(tert-butyl)-L-threonyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[[(3S)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-isopropylglycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-methyl-L-isoleucyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[2-methyl-4-[(2R)-2-methylpyrrolidin-1-yl]-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[2-methyl-4-[(2R)-2-methylpyrrolidin-1-yl]-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile
-
75% plasma DPP-IV inhibition after 30 min at 3 mg/kg oral dose, 48% plasma DPP-IV inhibition after 8 h at 3 mg/kg oral dose
(2S,4S)-4-fluoro-1-(N-[2-methyl-4-[4-(methylsulfonyl)piperazin-1-yl]-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[2-methyl-4-[4-(methylsulfonyl)piperazin-1-yl]-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile
-
64% plasma DPP-IV inhibition after 30 min at 3 mg/kg oral dose, 7% plasma DPP-IV inhibition after 8 h at 3 mg/kg oral dose
(2S,4S)-4-fluoro-1-(N-[2-[(4-cyanobenzyl)amino]-1,1-dimethylethyl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[2-[(5-cyanopyridin-2-yl)-amino]ethyl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(O-methyl-L-threonyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-([[2-methyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-yl]amino]acetyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-([[2-methyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-yl]amino]acetyl)pyrrolidine-2-carbonitrile
-
77% plasma DPP-IV inhibition after 30 min at 3 mg/kg oral dose, 56% plasma DPP-IV inhibition after 8 h at 3 mg/kg oral dose
(2S,4S)-4-fluoro-1-L-valyl-pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-ylcarbonyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[([4-[(3R)-3-fluoropyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[([4-[(3R)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[([4-[(3R)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
-
63% plasma DPP-IV inhibition after 30 min at 3 mg/kg oral dose, 15% plasma DPP-IV inhibition after 8 h at 3 mg/kg oral dose
(2S,4S)-4-fluoro-1-[([4-[(3S)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(1-methyl-1-pyridin-2-ylethyl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(2-hydroxy-1,1-dimethylethyl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(2-methoxy-1,1-dimethylethyl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(3-hydroxy-1-adamantyl)-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(3-isopropoxypropyl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(3-methoxy-1-adamantyl)-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(5-hydroxy-2-adamantyl)-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[1-(2-furyl)-1-methylethyl]-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[1-(hydroxymethyl)cyclopentyl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[1-methyl-1-(2-thienyl)-ethyl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-(pyridin-2-ylamino)ethyl]-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-(4-methylpiperazin-1-yl)-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-(morpholin-4-yl)-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-(morpholin-4-yl)-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
89% plasma DPP-IV inhibition after 30 min at 3 mg/kg oral dose, 59% plasma DPP-IV inhibition after 8 h at 3 mg/kg oral dose
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-oxo-4-(4-oxopiperidin-1-yl)butan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-oxo-4-(piperidin-1-yl)butan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-oxo-4-(piperidin-1-yl)butan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
86% plasma DPP-IV inhibition after 30 min at 3 mg/kg oral dose, 74% plasma DPP-IV inhibition after 8 h at 3 mg/kg oral dose
(2S,4S)-4-fluoro-1-[[(3S)-7-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[[(3S)-7-methoxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-N-ethyl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methyl-N-prop-2-yn-1-ylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methyl-N-propylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-N,5-dimethylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-cyclopropyl-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(morpholin-4-ylcarbonyl)pyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(piperidin-1-ylcarbonyl)pyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(pyrrolidin-1-ylcarbonyl)pyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-allyl-N-(cyanomethyl)-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N4-benzyl-N2-(cyanomethyl)-N2-ethyl-5-methylpyrrolidine-2,4-dicarboxamide
-
-
(2S,5R)-1-[(2R)-2-amino-2-cyclohexylacetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-methylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-vinylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(2R)-2-amino-4-methylpentanoyl]-5-ethynylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(2R)-2-amino-4-methylpentanoyl]-5-methylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(cyclohexylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(cyclopentylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(cyclopentylamino)acetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(tert-butylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[[(cis-1-ethyl-4-hydroxycyclohexyl)amino]acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
-
(2S,5S)-1-[(cyclopentylamino)acetyl]-5-methylpyrrolidine-2-carbonitrile
-
-
(3'S,5'S)-5'-(1,3-thiazolidin-3-ylcarbonyl)-1,3'-bipyrrolidine
-
-
(3,3-difluoro-pyrrolidin-1-yl)-[(2S,4R)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin)-2-yl]-methanone
-
-
(3,3-difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl)-piperazin-1-yl)-pyrrolidin-2-yl]-methanone
-
PF-00734200, potent, selective, orally active dipeptidyl peptidase IV inhibitor
(3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)methanol
-
-
(3R)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium
-
-
(3R)-1-[6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimidin-4-yl]pyrrolidin-3-ol
-
-
(3R)-3-amino-1-(2-cyclopropyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-(2-phenyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-(3-cyclopropyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-(3-ethyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-(5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-diaminophosphinyl-2-piperidinone
-
IC50: 46 nM
(3R)-3-amino-1-[(2S)-2-([[2-(trifluoromethyl)pyrimidin-4-yl]oxy]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-([[4-(trifluoromethyl)pyrimidin-2-yl]amino]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-([[6-(trifluoromethyl)pyridin-3-yl]amino]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-[(cyclopropylmethoxy)methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-[(pyrimidin-2-ylamino)methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-[[(5-fluoropyridin-2-yl)amino]methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-[[(5-fluoropyrimidin-2-yl)amino]methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4R)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4R)-1-methyl-4-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4R)-4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4R)-4-ethyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4S)-1-methyl-4-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4S)-1-methyl-4-propyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4S)-4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4S)-4-ethyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(5R)-5-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(5S)-5-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(6R)-6-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(6S)-6-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-2-(trifluoromethyl)-8-[4-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-3-(trifluoromethyl)-8-[2-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(1H-1,2,4-triazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(2-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(4-methoxybenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(cyclopropylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(prop-2-en-1-yl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-benzyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-3-(trifluoromethyl)-8-[2-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-(2-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-(4-methoxybenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-(prop-2-en-1-yl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-benzyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-ethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[2,3-bis(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]-4-(2,5-difluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[2-cyclopropyl-3-(trifluoromethyl)-4,7-dihydrofuro[2,3-c]pyridin-6(5H)-yl]-4-(2,5-difluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[3-(difluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
30% plasma DPP-IV inhibition after 30 min at 3 mg/kg oral dose, 20% plasma DPP-IV inhibition after 8 h at 3 mg/kg oral dose
(3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-(2-phenyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-(3-methyl-1,2,4-oxadiazol-5-yl)butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[(4R)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[(4S)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[(8R)-8-ethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(4-fluorobenzyl)-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(4-fluorophenyl)-3-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-ethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(2,2,2-trifluoroethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluorophenyl)-1-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluorophenyl)-3-(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluorophenyl)-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(trifluoromethyl)-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(2,2,2-trifluoroethyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-[4-(methylsulfanyl)phenyl]-3-(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-[4-(methylsulfonyl)phenyl]-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-[4-(trifluoromethyl)phenyl]-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(2,2,2-trifluoroethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(2,5-difluorophenyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorobenzyl)-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-2-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(hydroxymethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(pyridin-4-yl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-4,5-dihydro[1,2]oxazolo[3,4-c]pyridin-6(7H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-6,7-dihydro[1,2]oxazolo[4,3-c]pyridin-5(4H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-ethyl-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-methyl-2-(4-fluorophenyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-methyl-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-dimethyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-(2-hydroxyethyl)-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-tert-butyl-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-[2-(benzyloxy)ethyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
competitive, reversible inhibitor. Pharmacokinetic parameters
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
competitive, reversible inhibitor
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
competitive, reversible inhibitor. Pharmacokinetic parameters
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
pharmacokinetic parameters
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1-ethyl-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-1-(2-oxopropyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3S)-3-amino-4-(2-oxopiperidin-1-yl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3S)-3-amino-4-(2-oxopiperidin-1-yl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R,4R)-1-(1,3-benzothiazol-2-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-1-(1,3-benzothiazol-6-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-1-(2-methyl-3-oxo-2,3-dihydro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(2-methyl-4-oxo-4H-pyrimido[1,2-b]pyridazin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
pharmacokinetic properties
(3R,4R)-1-(2-naphthoyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-1-(2-oxo-2H-pyrimido[1,2-b]pyridazin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
; pharmacokinetic properties
(3R,4R)-1-(3,4-difluorobenzyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-1-(3-ethyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
-
(3R,4R)-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
pharmacokinetic properties
(3R,4R)-1-(4-cyanopyridin-2-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(4-cyclopropylpyrido[3,2-d]pyrimidin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
-
(3R,4R)-1-(6-piperidin-1-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
-
(3R,4R)-1-(6-pyrrolidin-1-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
-
(3R,4R)-1-(isoquinolin-3-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-1-isoquinolin-1-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-phenyl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pteridin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyrazino[2,3-b]pyrazin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyridin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyridin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyridin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyrido[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyrido[2,3-b]pyrazin-6-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-quinolin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-quinoxalin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[(5-chloro-1-benzofuran-2-yl)carbonyl]-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-1-[1,2,4]triazolo[4,3-a]pyrimidin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
pharmacokinetic properties
(3R,4R)-1-[1,2,4]triazolo[4,3-b]pyridazin-6-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[1-methyl-1-(4-nitrophenyl)ethyl]-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-1-[2-(trifluoromethyl)imidazo[1,2-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[2-(trifluoromethyl)[1,2,4]triazolo[1,5-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[3-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[3-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[4-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[4-[3-(methylsulfonyl)phenyl]-1,3,5-triazin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
-
(3R,4R)-1-[5-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[6-(3,3-difluoropyrrolidin-1-yl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
-
(3R,4R)-1-[6-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[6-[2-(trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
-
(3R,4R)-1-[6-[3-(methylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
-
(3R,4R)-3-amino-N-phenyl-4-(2,4,5-trifluorophenyl)piperidine-1-carboxamide
-
-
(3R,4R)-3-butyl-1-(3,4,5-trimethoxyphenyl)piperidin-4-amine
-
-
(3R,4R)-3-butyl-1-(3,4-dimethoxyphenyl)piperidin-4-amine
-
-
(3R,4R)-3-butyl-1-(4-methylphenyl)piperidin-4-amine
-
-
(3R,4R)-3-butyl-1-(4-phenoxyphenyl)piperidin-4-amine
-
-
(3R,4R)-3-butyl-1-(6-methoxybiphenyl-3-yl)piperidin-4-amine
-
-
(3R,4R)-3-butyl-1-naphthalen-2-ylpiperidin-4-amine
-
-
(3R,4R)-3-butyl-1-phenylpiperidin-4-amine
-
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-3-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-3-ylmethyl)pyrrolidin-3-amine
-
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-6-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1,2,3-thiadiazol-4-yl)benzyl]pyrrolidin-3-amine
-
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-1,2,4-triazol-1-yl)benzoyl]pyrrolidin-3-amine
-
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-amine
-
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-tetrazol-1-yl)benzoyl]pyrrolidin-3-amine
-
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-tetrazol-1-yl)benzyl]pyrrolidin-3-amine
-
-
(3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-(6-pyridin-3-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-acetyl-4-(2,4-dichlorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-benzyl-4-(2,4-dichlorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[4-[3-(methylsulfonyl)phenyl]-1,3,5-triazin-2-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
efficacious in vivo, lowering blood glucose in ZDF rats that were allowed to feed freely on a mixed meal
(3R,4S)-1-[4-[3-(methylsulfonyl)phenyl]-1,3,5-triazin-2-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(2-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(2-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(2-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(3-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(3-chlorophenyl)pyrimidin-4-yl]-4-phenylpyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(3-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(3-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(3-nitrophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(3-thienyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(4-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(4-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(4-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(4-methoxyphenyl)pyrimidin-4-yl]-4-phenylpyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(6-methoxypyridin-3-yl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-[3-(methylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine