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Literature summary for 3.4.14.5 extracted from

  • Balzarini, J.; Andersson, E.; Schols, D.; Proost, P.; Van Damme, J.; Svennerholm, B.; Horal, P.; Vahlne, A.
    Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)) (2004), Int. J. Biochem. Cell Biol., 36, 1848-1859.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
L-isoleucinepyrrolidine IC50: 0.022 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.159
-
 Gly-Pro-glycinamide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gly-Pro-glycinamide + H2O Homo sapiens CD26 plays a direct regulatory and indispensable role in the eventual antiretroviral activity of small synthetic molecules such as the antiretroviral prodrug Gly-Pro-glycinamide ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte cell line CEM, C8166, Molt4/C8, MT-4 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-Phe-4-nitroanilide + H2O
-
 Homo sapiens Gly-Phe + 4-nitroaniline
-
 ?
Gly-Pro-glycinamide + H2O CD26 plays a direct regulatory and indispensable role in the eventual antiretroviral activity of small synthetic molecules such as the antiretroviral prodrug Gly-Pro-glycinamide Homo sapiens ?
-
 ?
Gly-Pro-glycinamide + H2O the anti-HIV drug Gly-Pro-glycinamide is not active as such, but rather behaves as a prodrug that must be obligatorily cleaved by VD26/DPP IV to Gly-Pro and glycinamide to exert its antiretroviral activity Homo sapiens Gly-Pro + glycinamide
-
 ?

Synonyms

Synonyms Comment Organism
CD26
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.022
-
 IC50: 0.022 mM Homo sapiens L-isoleucinepyrrolidine