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Literature summary for 3.4.14.5 extracted from

  • McIntyre, H.F.; Grant, P.
    Dipeptidyl peptidase-IV inhibitors: fixing type 2 diabetes? (2007), Br. J. Hosp. Med. (Lond. ), 68, 599-602.
    View publication on PubMed

Application

Application Comment Organism
medicine DPP-IV inhibitors are potentially important therapies in diabetes Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2R)-1-[N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl]pyrrolidine-2-carbonitrile
-
Homo sapiens
saxagliptin
-
Homo sapiens
sitagliptin
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucagon-like peptide-1 + H2O Homo sapiens DPP-IV is the main proteolytic enzyme responsible for the rapid inactivation of glucagon-like peptide-1 into metabolites that are devoid of insulin-releasing activity ?
-
?
glucose-dependent insulinotropic polypeptide + H2O Homo sapiens DPP-IV is the main proteolytic enzyme responsible for the rapid inactivation of glucose-dependent insulinotropic polypeptide into metabolites that are devoid of insulin-releasing activity ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucagon-like peptide-1 + H2O
-
Homo sapiens ?
-
?
glucagon-like peptide-1 + H2O DPP-IV is the main proteolytic enzyme responsible for the rapid inactivation of glucagon-like peptide-1 into metabolites that are devoid of insulin-releasing activity Homo sapiens ?
-
?
glucose-dependent insulinotropic polypeptide + H2O
-
Homo sapiens ?
-
?
glucose-dependent insulinotropic polypeptide + H2O DPP-IV is the main proteolytic enzyme responsible for the rapid inactivation of glucose-dependent insulinotropic polypeptide into metabolites that are devoid of insulin-releasing activity Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
DPP-IV
-
Homo sapiens