Any feedback?
Literature summary for 3.4.14.5 extracted from
- Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin (2008), Bioorg. Med. Chem. Lett., 18, 479-484.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| atorvastatin | competitive | Sus scrofa |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glucagon-like peptide-1 + H2O | Sus scrofa | dipeptidyl peptidase-IV is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1and glucose-dependent insulinotropic polypeptide | ? | - |
? | |
| glucose-dependent insulinotropic polypeptide + H2O | Sus scrofa | dipeptidyl peptidase-IV is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1and glucose-dependent insulinotropic polypeptide | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glucagon-like peptide-1 + H2O | dipeptidyl peptidase-IV is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1and glucose-dependent insulinotropic polypeptide | Sus scrofa | ? | - |
? | |
| glucose-dependent insulinotropic polypeptide + H2O | dipeptidyl peptidase-IV is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1and glucose-dependent insulinotropic polypeptide | Sus scrofa | ? | - |
? | |
| Gly-Pro-p-nitroanilide + H2O | - |
Sus scrofa | Gly-Pro + p-nitroaniline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dipeptidyl peptidase-IV | - |
Sus scrofa |
| DPP-IV | - |
Sus scrofa |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0578 | - |
atorvastatin | 37°C, pH 8.0 | Sus scrofa | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.175 | - |
37°C, pH 8.0 | Sus scrofa | atorvastatin | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
