Literature summary for 3.4.14.5 extracted from

Yamazaki, K.; Yasuda, N.; Inoue, T.; Nagakura, T.; Kira, K.; Shinoda, M.; Saeki, T.; Tanaka, I.
7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one is a novel competitive and selective inhibitor of dipeptidyl peptidase IV with an antihyperglycemic activity (2006), J. Pharmacol. Exp. Ther., 319, 1253-1257.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-nitrobenzyl[(5S)-5-amino-6-oxo-6-(1-pyrrolidinyl)hexyl]carbamate	-	Homo sapiens
7-but-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one	a competitive and selective inhibitor of dipeptidyl peptidase IV with an antihyperglycemic activity	Homo sapiens
7-but-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one trifluoroacetate	-	Homo sapiens
vildagliptin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Gly-Pro-p-nitroanilide + H2O	-	Homo sapiens	Gly-Pro + p-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
DPP-IV	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000089	-	-	Homo sapiens	7-but-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one trifluoroacetate
0.00021	-	-	Homo sapiens	4-nitrobenzyl[(5S)-5-amino-6-oxo-6-(1-pyrrolidinyl)hexyl]carbamate

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Release 2023.1 (January 2023)