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Literature summary for 3.4.14.5 extracted from

  • Kim, S.J.; Nian, C.; Doudet, D.J.; McIntosh, C.H.
    Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice (2008), Diabetes, 57, 1331-1339.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
sitagliptin MK0431, potent inhibitor, inhibition of DPP-IV with sitagliptin (dose of 4g/kg/day over 7 days) prolongs islet graft retention in a type 1 diabetes mouse model Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucagon-like peptide 1 + H2O Mus musculus
-
?
-
?
glucose-dependent insulinotropic peptide + H2O Mus musculus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucagon-like peptide 1 + H2O
-
Mus musculus ?
-
?
glucose-dependent insulinotropic peptide + H2O
-
Mus musculus ?
-
?
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
-
Mus musculus Gly-L-Pro + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase IV
-
Mus musculus
DPP-IV
-
Mus musculus