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Literature summary for 3.4.14.5 extracted from

  • Kajiyama, H.; Shibata, K.; Ino, K.; Mizutani, S.; Nawa, A.; Kikkawa, F.
    The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells (2010), Cancer Sci., 101, 347-354.
    View publication on PubMed
Search for more literature for 3.4.14.5

Application

Application Comment Organism
medicine DPPIV expression may be an in vivo marker of tumor sensitivity to paclitaxel treatment Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Diprotin A specific inhibitor of DPPIV enzyme activity, almost complete inhibition at 0.1 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ES-2 cell
-
 Homo sapiens
-
HEY cell
-
 Homo sapiens
-
HRA cell
-
 Homo sapiens
-
KOC-7C cell
-
 Homo sapiens
-
NOS-2 cell
-
 Homo sapiens
-
NOS-4 cell
-
 Homo sapiens
-
ovarian carcinoma cell
-
 Homo sapiens
-
RMG-I cell
-
 Homo sapiens
-
RMG-II cell
-
 Homo sapiens
-
SKOV-3 cell
-
 Homo sapiens
-
TAOV cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-L-Pro-4-nitroanilide + H2O
-
 Homo sapiens Gly-L-Pro + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
CD26
-
 Homo sapiens
dipeptidyl peptidase IV
-
 Homo sapiens
DPPIV
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function DPPIV overexpression may lead to the reduced tumorigenicity and restoration of sensitivity to paclitaxel in epithelial ovarian carcinoma cells in vitro and in vivo Homo sapiens