Literature summary for 3.4.14.5 extracted from

Abe, M.; Akiyama, T.; Umezawa, Y.; Yamamoto, K.; Nagai, M.; Yamazaki, H.; Ichikawa, Y.; Muraoka, Y.
Synthesis and biological activity of sulphostin analogues, novel dipeptidyl peptidase IV inhibitors (2005), Bioorg. Med. Chem., 13, 785-797.

Search for more literature for 3.4.14.5

Inhibitors

Inhibitors	Comment	Organism	Structure
(3R)-3-amino-1-diaminophosphinyl-2-piperidinone	IC50: 46 nM	Rattus norvegicus
(3S)-3-amino-1-diaminophosphinyl-2-perhydroazepinone	IC50: 130 nM	Rattus norvegicus
(3S)-3-amino-1-diaminophosphinyl-2-piperidinone	IC50: 94 nM	Rattus norvegicus
(3S)-3-amino-1-diaminophosphinyl-2-pyrrolidinone	IC50: 11 nM	Rattus norvegicus
sulphostin	IC50: 21 nM	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Gly-Pro-2-naphthylamide + H2O	-	Rattus norvegicus	Gly-Pro + 2-naphthylamine	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000011	-	IC50: 11 nM	Rattus norvegicus	(3S)-3-amino-1-diaminophosphinyl-2-pyrrolidinone
0.000021	-	IC50: 21 nM	Rattus norvegicus	sulphostin
0.000046	-	IC50: 46 nM	Rattus norvegicus	(3R)-3-amino-1-diaminophosphinyl-2-piperidinone
0.000094	-	IC50: 94 nM	Rattus norvegicus	(3S)-3-amino-1-diaminophosphinyl-2-piperidinone
0.00013	-	IC50: 130 nM	Rattus norvegicus	(3S)-3-amino-1-diaminophosphinyl-2-perhydroazepinone

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Release 2023.1 (January 2023)