Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alogliptin | - |
Homo sapiens | |
alogliptin | - |
Mus musculus | |
alogliptin | - |
Rattus norvegicus | |
BI 1356 | competitive inhibitor, i.e. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione, proposed trade name Ondero, BI 1356 is more than 10000fold selective for DPP-4 than DPP-8, DPP-9, aminopeptidases N and P, prolyloligopeptidase, trypsin, plasmin, and thrombin and is 90-fold more selective than for fibroblast activation protein in vitro | Homo sapiens | |
BI 1356 | competitive inhibitor, i.e. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione, proposed trade name Ondero, BI 1356 is more than 10000fold selective for DPP-4 than DPP-8, DPP-9, aminopeptidases N and P, prolyloligopeptidase, trypsin, plasmin, and thrombin and is 90-fold more selective than for fibroblast activation protein in vitro | Mus musculus | |
BI 1356 | competitive inhibitor, i.e. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione, proposed trade name Ondero, BI 1356 is more than 10000fold selective for DPP-4 than DPP-8, DPP-9, aminopeptidases N and P, prolyloligopeptidase, trypsin, plasmin, and thrombin and is 90-fold more selective than for fibroblast activation protein in vitro | Rattus norvegicus | |
saxagliptin | - |
Homo sapiens | |
saxagliptin | - |
Mus musculus | |
saxagliptin | - |
Rattus norvegicus | |
sitagliptin | - |
Homo sapiens | |
sitagliptin | - |
Mus musculus | |
sitagliptin | - |
Rattus norvegicus | |
vildagliptin | - |
Homo sapiens | |
vildagliptin | - |
Mus musculus | |
vildagliptin | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucagon-like peptide + H2O | Mus musculus | - |
? | - |
? | |
glucagon-like peptide + H2O | Homo sapiens | - |
? | - |
? | |
glucagon-like peptide + H2O | Rattus norvegicus | - |
? | - |
? | |
glucose-dependent insulinotropic peptide + H2O | Mus musculus | - |
? | - |
? | |
glucose-dependent insulinotropic peptide + H2O | Homo sapiens | - |
? | - |
? | |
glucose-dependent insulinotropic peptide + H2O | Rattus norvegicus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Mus musculus | - |
blood plasma | - |
Rattus norvegicus | - |
Caco-2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucagon-like peptide + H2O | - |
Mus musculus | ? | - |
? | |
glucagon-like peptide + H2O | - |
Homo sapiens | ? | - |
? | |
glucagon-like peptide + H2O | - |
Rattus norvegicus | ? | - |
? | |
glucose-dependent insulinotropic peptide + H2O | - |
Mus musculus | ? | - |
? | |
glucose-dependent insulinotropic peptide + H2O | - |
Homo sapiens | ? | - |
? | |
glucose-dependent insulinotropic peptide + H2O | - |
Rattus norvegicus | ? | - |
? | |
H-Ala-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | H-Ala-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
H-Ala-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | H-Ala-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
H-Ala-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | H-Ala-L-Pro + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dipeptidyl peptidase 4 | - |
Mus musculus |
dipeptidyl peptidase 4 | - |
Homo sapiens |
dipeptidyl peptidase 4 | - |
Rattus norvegicus |
DPP-4 | - |
Mus musculus |
DPP-4 | - |
Homo sapiens |
DPP-4 | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000001 | - |
BI 1356 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000001 | - |
in 100 mM Tris-HCl, 100 mM NaCl, pH 7.8 | Homo sapiens | BI 1356 | |
0.000019 | - |
in 100 mM Tris-HCl, 100 mM NaCl, pH 7.8 | Homo sapiens | sitagliptin | |
0.000024 | - |
in 100 mM Tris-HCl, 100 mM NaCl, pH 7.8 | Homo sapiens | alogliptin | |
0.00005 | - |
in 100 mM Tris-HCl, 100 mM NaCl, pH 7.8 | Homo sapiens | saxagliptin | |
0.000062 | - |
in 100 mM Tris-HCl, 100 mM NaCl, pH 7.8 | Homo sapiens | vildagliptin |