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Literature summary for 3.4.14.5 extracted from

  • Biftu, T.; Scapin, G.; Singh, S.; Feng, D.; Becker, J.W.; Eiermann, G.; He, H.; Lyons, K.; Patel, S.; Petrov, A.; Sinha-Roy, R.; Zhang, B.; Wu, J.; Zhang, X.; Doss, G.A.; Thornberry, N.A.; Weber, A.E.
    Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin (2007), Bioorg. Med. Chem. Lett., 17, 3384-3387.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)cyclohexanamine the inhibitor has similar potency to sitagliptin and excellent pharmacokinetic properties Canis lupus familiaris
(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)cyclohexanamine the inhibitor has similar potency to sitagliptin and excellent pharmacokinetic properties Macaca mulatta
(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)cyclohexanamine the inhibitor has similar potency to sitagliptin and excellent pharmacokinetic properties Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
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Macaca mulatta
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Rattus norvegicus
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