Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.14.5 extracted from

  • Miller, S.; St Onge, E.L.
    Sitagliptin: a dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes (2006), Ann. Pharmacother., 40, 1336-1343.
    View publication on PubMed
Search for more literature for 3.4.14.5

Application

Application Comment Organism
medicine sitagliptin is a dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Use of sitagliptin as adjunct therapy to sulfonylureas and metformin. An advantage of sitagliptin use is that it appears to be free from the adverse effects of weight gain and hypoglycemia that are associated with currently available treatments Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
sitagliptin potent, competitive, reversible inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucagon-like peptide-1 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow high activity Homo sapiens
-
epithelial cell
-
 Homo sapiens
-
intestine high activity Homo sapiens
-
kidney high activity Homo sapiens
-
liver
-
 Homo sapiens
-
lymphoid cell
-
 Homo sapiens
-
marrow cell
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-
thymus
-
 Homo sapiens
-
vascular endothelium
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucagon-like peptide-1 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
DPP-IV
-
 Homo sapiens