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Literature summary for 3.4.14.5 extracted from

  • Yasuda, N.; Nagakura, T.; Inoue, T.; Yamazaki, K.; Katsutani, N.; Takenaka, O.; Clark, R.; Matsuura, F.; Emori, E.; Yoshikawa, S.; Kira, K.; Ikuta, H.; Okada, T.; Saeki, T.; Asano, O.; Tanaka, I.
    E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor (2006), Eur. J. Pharmacol., 548, 181-187.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate selective and competitive dipeptidyl peptidase-IV inhibitor Canis lupus familiaris
3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate selective and competitive dipeptidyl peptidase-IV inhibitor Homo sapiens
3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate selective and competitive dipeptidyl peptidase-IV inhibitor Mus musculus
4-nitrobenzyl[(5S)-5-amino-6-oxo-6-(1-pyrrolidinyl)hexyl]carbamate
-
 Homo sapiens
Val-pyrrolidide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Mus musculus
-
blood plasma
-
 Homo sapiens
-
blood plasma
-
 Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-Pro-p-nitroanilide + H2O
-
 Mus musculus Gly-Pro + p-nitroaniline
-
 ?
Gly-Pro-p-nitroanilide + H2O
-
 Homo sapiens Gly-Pro + p-nitroaniline
-
 ?
Gly-Pro-p-nitroanilide + H2O
-
 Canis lupus familiaris Gly-Pro + p-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase-IV
-
 Mus musculus
dipeptidyl peptidase-IV
-
 Homo sapiens
dipeptidyl peptidase-IV
-
 Canis lupus familiaris

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
 recombinant enzyme Mus musculus 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate
0.0001
-
 plasma enzyme Homo sapiens 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate
0.00013
-
 recombinant enzyme Homo sapiens 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate
0.00028
-
 plasma enzyme Mus musculus 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate
0.00036
-
 plasma enzyme Canis lupus familiaris 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate
0.214
-
 recombinant enzyme Homo sapiens 4-nitrobenzyl[(5S)-5-amino-6-oxo-6-(1-pyrrolidinyl)hexyl]carbamate
0.44
-
 recombinant enzyme Homo sapiens Val-pyrrolidide