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Literature summary for 3.4.14.5 extracted from
- A collagen-binding glycoprotein on the surface of mouse fibroblasts is identified as dipeptidyl peptidase IV (1988), Biochem. J., 252, 723-731.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ala-Pro-Gly | - |
Mus musculus |  |
| diisopropyl fluorophosphate | - |
Mus musculus | |
| Gly-Pro-Ala | - |
Mus musculus | |
| phenylmethylsulfonyl fluoride | - |
Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.63 | - |
Gly-Pro-4-nitroanilide | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasmic membrane | - |
Mus musculus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
2 * 55000, SDS-PAGE | Mus musculus |
| 100000 | - |
gel filtration | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | may play a role in cell attachment to collagen | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | glycoprotein | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | normal, 3T3, and transformed, 3T12 | Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0683 | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gly-Pro-4-nitroanilide + H2O | - |
Mus musculus | Gly-Pro + 4-nitroaniline | - |
? | |
| additional information | specifically recognized immobilized gelatin and type I collagen | Mus musculus | ? | - |
? | |
| additional information | may play a role in cell attachment to collagen | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 55000, SDS-PAGE | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 6 | hydrolysis of Gly-Pro-4-nitroanilide, citrate buffer | Mus musculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 8 | about 40% of maximal activity at pH 4.0 and at pH 8.0, hydrolysis of Gly-Pro-4-nitroanilide, citrate buffer | Mus musculus |
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Release 2023.1 (January 2023)
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