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Literature summary for 3.4.14.5 extracted from

  • Zhu, L.; Tamvakopoulos, C.; Xie, D.; Dragovic, J.; Shen, X.; Fenyk-Melody, J.E.; Schmidt, K.; Bagchi, A.; Griffin, P.R.; Thornberry, N.A.; Sinha Roy, R.
    The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38) (2003), J. Biol. Chem., 278, 22418-22423.
    View publication on PubMed
Search for more literature for 3.4.14.5

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
gastrin releasing peptide-(1-27) + H2O Mus musculus i.e. GRP-(1-27), cleaves N-terminal dipeptide VP ?
-
 ir
gastrin releasing peptide-(3-27) + H2O Mus musculus i.e. GRP-(3-27), cleaves N-terminal dipeptide LP ?
-
 ir
glucagon-like peptide 1 + H2O Mus musculus i.e. GLP-1, degradation, regulation of activity, cleaves N-terminal dipeptide HA ?
-
 ir
glucagon-like peptide 2 + H2O Mus musculus i.e. GLP-1, degradation, regulation of activity, cleaves N-terminal dipeptide HA ?
-
 ir
glucose-dependent insulinotropic polypeptide + H2O Mus musculus i.e. GIP, cleaves N-terminal dipeptide YA ?
-
 ir
growth hormone releasing hormone-(1-29) fragment + H2O Mus musculus i.e. GHRH-(1-29), cleaves N-terminal dipeptide YA ?
-
 ir
growth hormone releasing hormone-(1-44) fragment + H2O Mus musculus i.e. GHRH-(1-44), cleaves N-terminal dipeptide YA ?
-
 ir
growth hormone-(1-43) fragment + H2O Mus musculus cleaves N-terminal dipeptide FP ?
-
 ir
incretin hormone + H2O Mus musculus
-
 ?
-
 ir
additional information Mus musculus substrate specificity, cleavage of N-terminal dipeptide, no activity with vasoactive intestinal peptide, glucagon and secretin are poor substrates ?
-
 ?
oxyntomodulin + H2O Mus musculus cleaves N-terminal dipeptide HS ?
-
 ir
pituitary adenylate cyclase-activating polypeptide-(1-27) + H2O Mus musculus i.e. PACAP27, cleaves N-terminal dipeptide HS ?
-
 ?
pituitary adenylate cyclase-activating polypeptide-(1-38) + H2O Mus musculus i.e. PACAP38, enzyme plays a major role in the degradation of circulating PACAP38, cleaves N-terminal dipeptide HS ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 wild-type mice and enzyme-deficient mutant strain C57BI/6 mice
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 substrate specificity Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Pro-7-amido-4-methylcoumarin + H2O
-
 Mus musculus Ala-Pro + 7-amino-4-methylcoumarin
-
 ?
gastrin releasing peptide-(1-27) + H2O i.e. GRP-(1-27), cleaves N-terminal dipeptide VP Mus musculus ?
-
 ir
gastrin releasing peptide-(3-27) + H2O i.e. GRP-(3-27), cleaves N-terminal dipeptide LP Mus musculus ?
-
 ir
glucagon-like peptide 1 + H2O i.e. GLP-1, degradation, regulation of activity Mus musculus ?
-
 ?
glucagon-like peptide 1 + H2O i.e. GLP-1, degradation, regulation of activity, cleaves N-terminal dipeptide HA Mus musculus ?
-
 ir
glucagon-like peptide 2 + H2O i.e. GLP-1, degradation, regulation of activity, cleaves N-terminal dipeptide HA Mus musculus ?
-
 ir
glucose-dependent insulinotropic polypeptide + H2O i.e. GIP Mus musculus ?
-
 ?
glucose-dependent insulinotropic polypeptide + H2O i.e. GIP, cleaves N-terminal dipeptide YA Mus musculus ?
-
 ir
growth hormone releasing hormone-(1-29) fragment + H2O i.e. GHRH-(1-29), cleaves N-terminal dipeptide YA Mus musculus ?
-
 ir
growth hormone releasing hormone-(1-44) fragment + H2O i.e. GHRH-(1-44), cleaves N-terminal dipeptide YA Mus musculus ?
-
 ir
growth hormone-(1-43) fragment + H2O
-
 Mus musculus ?
-
 ?
growth hormone-(1-43) fragment + H2O cleaves N-terminal dipeptide FP Mus musculus ?
-
 ir
incretin hormone + H2O
-
 Mus musculus ?
-
 ?
incretin hormone + H2O
-
 Mus musculus ?
-
 ir
additional information substrate specificity, cleavage of N-terminal dipeptide, no activity with vasoactive intestinal peptide, glucagon and secretin are poor substrates Mus musculus ?
-
 ?
oxyntomodulin + H2O
-
 Mus musculus ?
-
 ir
oxyntomodulin + H2O cleaves N-terminal dipeptide HS Mus musculus ?
-
 ir
pituitary adenylate cyclase-activating polypeptide-(1-27) + H2O i.e. PACAP27, cleaves N-terminal dipeptide HS Mus musculus ?
-
 ?
pituitary adenylate cyclase-activating polypeptide-(1-38) + H2O i.e. PACAP38, a critical mediator in lipid and carbohydrate metabolism Mus musculus ?
-
 ?
pituitary adenylate cyclase-activating polypeptide-(1-38) + H2O i.e. PACAP38, enzyme plays a major role in the degradation of circulating PACAP38, cleaves N-terminal dipeptide HS Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
dipeptidyl dipeptidase IV
-
 Mus musculus
DP-IV
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus