Application | Comment | Organism |
---|---|---|
medicine | enzyme is able to truncate the commercial amyloid beta40 and amyloid beta42 peptides, to hinder the fibril formation by them and to participate in the disaggregation of preformed fibrils of these peptides. Dipeptidyl peptidase IV hinders the peptide aggregation/fibrillation during 3-4 days incubation in 20 mM phosphate buffer, pH 7.4, 37°C by 50-80%. In the presence of dipeptidyl peptidase IV, the preformed fibrils are disaggregated by 30-40% | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0375 | - |
amyloid beta40 | pH 7.4, 37°C | Bos taurus | |
0.138 | - |
amyloid beta42 | pH 7.4, 37°C | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta40 + H2O | - |
Bos taurus | ? | enzyme is able to truncate the commercial amyloid beta40 and amyloid beta42 peptides, to hinder the fibril formation by them and to participate in the disaggregation of preformed fibrils of these peptides | ? | |
amyloid beta42 + H2O | - |
Bos taurus | ? | enzyme is able to truncate the commercial amyloid beta40 and amyloid beta42 peptides, to hinder the fibril formation by them and to participate in the disaggregation of preformed fibrils of these peptides | ? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.027 | - |
amyloid beta42 | pH 7.4, 37°C | Bos taurus | |
0.063 | - |
amyloid beta40 | pH 7.4, 37°C | Bos taurus |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.195 | - |
amyloid beta42 | pH 7.4, 37°C | Bos taurus | |
1.7 | - |
amyloid beta40 | pH 7.4, 37°C | Bos taurus |