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Literature summary for 3.4.14.5 extracted from

  • Koo, K.D.; Kim, M.J.; Kim, S.; Kim, K.H.; Hong, S.Y.; Hur, G.C.; Yim, H.J.; Kim, G.T.; Han, H.O.; Kwon, O.H.; Kwon, T.S.; Koh, J.S.; Lee, C.S.
    Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: oxadiazolyl ketones (2007), Bioorg. Med. Chem. Lett., 17, 4167-4172.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-[(2R)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]cyclopentyl]-2-(tricyclo[3.3.1.13,7]dec-1-ylamino)ethanone
-
Homo sapiens
1-[(2R)-4,4-difluoro-2-[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]cyclopentyl]-2-(tricyclo[3.3.1.13,7]dec-1-ylamino)ethanone
-
Homo sapiens
1-[(2R,4R)-4-fluoro-2-[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]cyclopentyl]-2-(tricyclo[3.3.1.13,7]dec-1-ylamino)ethanone
-
Homo sapiens
1-[(4R)-4-[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]tetrahydrothiophen-3-yl]-2-(tricyclo[3.3.1.13,7]dec-1-ylamino)ethanone
-
Homo sapiens
2-(N-tert-butylglycyl-L-prolyl)-5-(1-methylcyclohexyl)-1,3,4-oxadiazole
-
Homo sapiens
2-(N-tert-butylglycyl-L-prolyl)-5-(2,4,6-trimethylphenyl)-1,3,4-oxadiazole
-
Homo sapiens
2-methyl-2-[(2-[(2S)-2-[(5-methyl-1,2,4-oxadiazol-3-yl)carbonyl]pyrrolidin-1-yl]-2-oxoethyl)amino]propanoic acid
-
Homo sapiens
2-tert-butyl-5-(N-tert-butylglycyl-L-prolyl)-1,3,4-oxadiazole
-
Homo sapiens
2-tert-butyl-5-[N-(2-hydroxy-1,1-dimethylethyl)glycyl-(4S)-4-fluoro-L-prolyl]-1,3,4-oxadiazole pharmacokinetic data Canis lupus familiaris
2-tert-butyl-5-[N-(2-hydroxy-1,1-dimethylethyl)glycyl-(4S)-4-fluoro-L-prolyl]-1,3,4-oxadiazole the inhibitor shows good potency against DPPIV, and good selectivity against DPPII, DPPVIII, and elastase Homo sapiens
2-tert-butyl-5-[N-(2-hydroxy-1,1-dimethylethyl)glycyl-(4S)-4-fluoro-L-prolyl]-1,3,4-oxadiazole pharmacokinetic data Rattus norvegicus
2-tert-butyl-5-[N-(2-hydroxy-1,1-dimethylethyl)glycyl-L-prolyl]-1,3,4-oxadiazole
-
Homo sapiens
2-tert-butyl-5-[N-[2-(4-fluorophenyl)-1,1-dimethylethyl]glycyl-(4S)-4-fluoro-L-prolyl]-1,3,4-oxadiazole
-
Homo sapiens
2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]-1-[(2R)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]cyclopentyl]ethanone
-
Homo sapiens
2-[N-tert-butylglycyl-(4S)-4-fluoro-L-prolyl]-5-(1,1-dimethylpropyl)-1,3,4-oxadiazole
-
Homo sapiens
2-[N-tert-butylglycyl-(4S)-4-fluoro-L-prolyl]-5-cyclohexyl-1,3,4-oxadiazole
-
Homo sapiens
3-(N-tert-butylglycyl-L-prolyl)-5-(2-methylcyclohexyl)-1,2,4-oxadiazole
-
Homo sapiens
5-tert-butyl-3-[N-(2-hydroxy-1,1-dimethylethyl)glycyl-(4S)-4-fluoro-L-prolyl]-1,2,4-oxadiazole
-
Homo sapiens
5-tert-butyl-3-[N-(2-hydroxy-1,1-dimethylethyl)glycyl-L-prolyl]-1,2,4-oxadiazole
-
Homo sapiens
5-tert-butyl-3-[N-tert-butylglycyl-(4S)-4-fluoro-L-prolyl]-1,2,4-oxadiazole
-
Homo sapiens
[(2S)-1-([[2-(4-fluorophenyl)-1,1-dimethylethyl]amino]acetyl)pyrrolidin-2-yl](1,2,4-oxadiazol-3-yl)methanone
-
Homo sapiens
[(2S)-1-[(tert-butylamino)acetyl]pyrrolidin-2-yl][5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]methanone
-
Homo sapiens
[(2S)-1-[[(2-hydroxy-1,1-dimethylethyl)amino]acetyl]pyrrolidin-2-yl](5-methyl-1,2,4-oxadiazol-3-yl)methanone
-
Homo sapiens
[(2S)-1-[[(2-hydroxy-1,1-dimethylethyl)amino]acetyl]pyrrolidin-2-yl](5-methyl-1,3,4-oxadiazol-2-yl)methanone
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Synonyms

Synonyms Comment Organism
DPPIV
-
Homo sapiens
DPPIV
-
Rattus norvegicus
DPPIV
-
Canis lupus familiaris