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Literature summary for 3.4.14.5 extracted from

  • Mrestani-Klaus, C.; Fengler, A.; Faust, J.; Brandt, W.; Wrenger, S.; Reinhold, D.; Ansorge, S.; Neubert, K.
    N-terminal HIV-1 Tat nonapeptides as inhibitors of dipeptidyl peptidase IV. Conformational characterization (2000), Adv. Exp. Med. Biol., 477, 125-129.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N-terminal nonapeptide of HIV-1 Tat protein wild-type is a strong inhibitor, mutant exchange variants Ile5 and Leu6 show highly reduced inhibitory activity, replacement of Asp2 with Gly or Lys lead to enhanced inhibitory potency compared to the wild-type peptide, study of structure-function relationship Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is supposed to mediate the immunosuppressive effects of HIV-1 Tat protein, enzyme plays a central role in signal transduction processes ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline exopeptidase that cleaves dipeptides from the N-terminus of oligo- and polypeptides with the penultimate residue being proline or alanine Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte cell surface Homo sapiens
-
T-lymphocyte cell surface Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is supposed to mediate the immunosuppressive effects of HIV-1 Tat protein, enzyme plays a central role in signal transduction processes Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
CD26
-
Homo sapiens
dipeptidyl peptidase IV
-
Homo sapiens
DP IV
-
Homo sapiens