Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-terminal nonapeptide of HIV-1 Tat protein | wild-type is a strong inhibitor, mutant exchange variants Ile5 and Leu6 show highly reduced inhibitory activity, replacement of Asp2 with Gly or Lys lead to enhanced inhibitory potency compared to the wild-type peptide, study of structure-function relationship | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | bound | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is supposed to mediate the immunosuppressive effects of HIV-1 Tat protein, enzyme plays a central role in signal transduction processes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline | exopeptidase that cleaves dipeptides from the N-terminus of oligo- and polypeptides with the penultimate residue being proline or alanine | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | cell surface | Homo sapiens | - |
T-lymphocyte | cell surface | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is supposed to mediate the immunosuppressive effects of HIV-1 Tat protein, enzyme plays a central role in signal transduction processes | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CD26 | - |
Homo sapiens |
dipeptidyl peptidase IV | - |
Homo sapiens |
DP IV | - |
Homo sapiens |