Application | Comment | Organism |
---|---|---|
medicine | dipeptidyl peptidase IV functions as a chemorepellent of human neutrophils | Homo sapiens |
medicine | in a murine model of acute respiratory distress syndrome, aspirated bleomycin induces a significant increase in the number of neutrophils in the lungs after 3 d. Oropharyngeal aspiration of dipeptidyl peptidase IV inhibits the bleomycin-induced accumulation of mouse neutrophils | Mus musculus |
Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | in Insall chambers, dipeptidyl peptidase IV gradients below, similar to, and above the human serum dipeptidyl peptidase IV concentration cause movement of human neutrophils away from the higher concentration. A 1% dipeptidyl peptidase IV concentration difference between the front and back of the cell is sufficient to cause chemorepulsion. Neutrophil speed and viability are unaffected by dipeptidyl peptidase IV. Enzyme inhibitors block dipeptidyl peptidase IV-mediated chemorepulsion | Homo sapiens |