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Information on EC 2.7.11.10 - IkappaB kinase

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.11 Protein-serine/threonine kinases
                2.7.11.10 IkappaB kinase
IUBMB Comments
The enzyme phosphorylates IkappaB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-kappaB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
ikappabalpha, ikkbeta, ikkalpha, ikk complex, lrrk2 kinase, ikk-beta, tank-binding kinase 1, ikkepsilon, ikk-2, ikk-alpha, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + [IkappaB protein] = ADP + [IkappaB phosphoprotein]
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ATP + [IkB protein] = ADP + [IkB phosphoprotein]
show the reaction diagram
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