Information on EC - IkappaB kinase

for references in articles please use BRENDA:EC2.7.11.10
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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.11 Protein-serine/threonine kinases
       IkappaB kinase
IUBMB Comments
The enzyme phosphorylates IkappaB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-kappaB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
CHUK, I kappa B kinase alpha, I-kappa B kinase epsilon, I-kappa-B kinase epsilon, Ikappa B kinase alpha, IkappaB alpha kinase, IkappaB kinase, IkappaB kinase alpha, IkappaB kinase beta, IkappaB kinase complex, more
ATP + [IkappaB protein] = ADP + [IkappaB phosphoprotein]
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ATP + [IkB protein] = ADP + [IkB phosphoprotein]
show the reaction diagram