Literature summary for 2.7.11.10 extracted from

Molestina, R.E.; Sinai, A.P.
Detection of a novel parasite kinase activity at the Toxoplasma gondii parasitophorous vacuole membrane capable of phosphorylating host IkBa (2005), Cell. Microbiol., 7, 351-362.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
vacuolar membrane	parasitophorous, PVM	Toxoplasma gondii	5774	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [IkappaBalpha protein]	Toxoplasma gondii	parasite IKKalpha, localized in parasitophorous vacuole membrane, activates mouse' intracellular NF-kappaB through phosphorylation of host IkappaBalpha at Ser32 and Ser36 in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex	ADP + [IkappaBalpha phosphoprotein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Toxoplasma gondii	-	RH strain in mouse embryonic fibroblast host MEF cells, wild-type and IKKalpha- or IKKbeta-deficient host cells	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [GST-IkappaBalpha1-54 protein]	recombinant substrate derived from mouse IkappaBalpha	Toxoplasma gondii	ADP + [GST-IkappaBalpha1-54 phosphoprotein]	-	?
ATP + [IkappaB protein]	-	Toxoplasma gondii	ADP + [IkappaB phosphoprotein]	-	?
ATP + [IkappaBalpha protein]	parasite IKKalpha, localized in parasitophorous vacuole membrane, activates mouse' intracellular NF-kappaB through phosphorylation of host IkappaBalpha at Ser32 and Ser36 in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex	Toxoplasma gondii	ADP + [IkappaBalpha phosphoprotein]	-	?

Synonyms

Synonyms	Comment	Organism
IKK	-	Toxoplasma gondii

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Toxoplasma gondii

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Release 2023.1 (January 2023)