Cloned (Comment) | Organism |
---|---|
transient coexpression of IKKepsilon, IRF3, and TBK1 or IKKbeta in 293T cells, transient coexpression of IFN-beta or ISRE reporter genes and IKKepsilon or TBK1 in HEK293 cells with or without FLAG or GFP tag | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | IKKepsilon and TBK1 interference RNA blocks IRF3 activation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the noncanonical IkappaB kinase homologue IKKepsilon, beneath TANK-binding kinase-1 TBK-1, is required for activation of transcription factor NFkappaB and of interferon regulatory factor 3 IRF3, regulation and interaction, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
IKKepsilon is a noncanonical IkappaB kinase homologue | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the noncanonical IkappaB kinase homologue IKKepsilon, beneath TANK-binding kinase-1 TBK-1, is required for activation of transcription factor NFkappaB and of interferon regulatory factor 3 IRF3, regulation and interaction, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IKKepsilon | - |
Homo sapiens |