Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | hypoxia activates NFkappaB through a pathway involving activation of IkappaB kinase-beta, IKKbeta | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
transient expression of wild-type and mutant IKKbeta in HeLa cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
P191A | inactive IKKbeta mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | prolyl hydroxylase-1 negatively regulates IKKbeta, hydroxylation represses IKKbeta activity by altering protein expression or by preventing its activation through phosphorylation on S177/S181 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + IkappaBalpha | Homo sapiens | a step in NF-kappaB activation, the IKK complex, composed of IKKalpha, IKKbeta, and NEMO/IKKgamma, is the convergence point for many diverse NFkappaB-activating stimuli including TNFalpha, LPS, and IL-1, overview, IKKbeta is the primary positive regulator of NFkappaB activity in inflammatory processes, is the molecular link between inflammation and cancer | ADP + phosphorylated IkappaBalpha | - |
? | |
additional information | Homo sapiens | hypoxia alters the cellular pool of IKKalpha and IKKbeta, and activates NFkappaB through a pathway involving activation of IkappaB kinase-beta, IKKbeta, leading to phosphorylation-dependent degradation of IkappaBalpha and liberation of NFkappaB, overview, hypoxia-induced activation of the NFkappaB pathway is independent of HIF-1alpha, prolyl hydroxylase-1 negatively regulates IKKbeta | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | within its activation loop, IKKbeta contains an evolutionarily conserved LxxLAP consensus motif for hydroxylation by prolyl hydroxylases | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + IkappaBalpha | - |
Homo sapiens | ADP + phosphorylated IkappaBalpha | - |
? | |
ATP + IkappaBalpha | a step in NF-kappaB activation, the IKK complex, composed of IKKalpha, IKKbeta, and NEMO/IKKgamma, is the convergence point for many diverse NFkappaB-activating stimuli including TNFalpha, LPS, and IL-1, overview, IKKbeta is the primary positive regulator of NFkappaB activity in inflammatory processes, is the molecular link between inflammation and cancer | Homo sapiens | ADP + phosphorylated IkappaBalpha | - |
? | |
additional information | hypoxia alters the cellular pool of IKKalpha and IKKbeta, and activates NFkappaB through a pathway involving activation of IkappaB kinase-beta, IKKbeta, leading to phosphorylation-dependent degradation of IkappaBalpha and liberation of NFkappaB, overview, hypoxia-induced activation of the NFkappaB pathway is independent of HIF-1alpha, prolyl hydroxylase-1 negatively regulates IKKbeta | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | within its activation loop, IKKbeta and IKKalpha contain an evolutionarily conserved LxxLAP consensus motif for hydroxylation by prolyl hydroxylases, while p65, p50, IkappaBalpha, and NEMO/IKKgamma are without this sequence | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
IkappaB kinase-beta | - |
Homo sapiens |
IKKbeta | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |