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Literature summary for 2.7.11.10 extracted from

  • Chiang, P.C.; Kishore, N.N.; Thompson, D.C.
    Combined use of pharmacokinetic modeling and a steady-state delivery approach allows early assessment of IkappaB kinase-2 (IKK-2) target safety and efficacy (2010), J. Pharm. Sci., 99, 1278-1287.
    View publication on PubMed

Application

Application Comment Organism
medicine the role of IKK-2 in regulating NF-kappaB signaling in resonse to proinflammatory stimuli has made IKK-2 a primary anti-inflammation therapeutic target Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
PHA-408 selective IKK-2 inhibitor Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [IkappaB protein] Rattus norvegicus
-
ADP + [IkappaB phosphoprotein]
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Lewis rat
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [IkappaB protein]
-
Rattus norvegicus ADP + [IkappaB phosphoprotein]
-
?

Synonyms

Synonyms Comment Organism
IkappaB kinase-2
-
Rattus norvegicus
IKK-2
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00001
-
less than 0.000010 Rattus norvegicus PHA-408

General Information

General Information Comment Organism
physiological function IKK-2 plays a role in regulating NF-kappaB signaling Rattus norvegicus