Application | Comment | Organism |
---|---|---|
medicine | the role of IKK-2 in regulating NF-kappaB signaling in resonse to proinflammatory stimuli has made IKK-2 a primary anti-inflammation therapeutic target | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PHA-408 | selective IKK-2 inhibitor | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [IkappaB protein] | Rattus norvegicus | - |
ADP + [IkappaB phosphoprotein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Lewis rat | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [IkappaB protein] | - |
Rattus norvegicus | ADP + [IkappaB phosphoprotein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IkappaB kinase-2 | - |
Rattus norvegicus |
IKK-2 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00001 | - |
less than 0.000010 | Rattus norvegicus | PHA-408 |
General Information | Comment | Organism |
---|---|---|
physiological function | IKK-2 plays a role in regulating NF-kappaB signaling | Rattus norvegicus |