Application | Comment | Organism |
---|---|---|
medicine | IKKalpha is responsible for the development of acantholytic squamous cell carcinoma (ASCC), a human SCC variant | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enhanced IKKalpha expression increases both early and terminal differentiation of human keratinocytes through an E-cadherin-dependent mechanism | Homo sapiens |
additional information | increased expression of IKKalpha in mouse tumorigenic epidermal cells (PDVC57) leads to changes in the differentiation pattern of the resulting squamous cell carcinomas, originating a distinct histological variant that resembles the human acantholytic squamous cell carcinomas (ASCC) variant | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15111 | - |
- |
Mus musculus | Q60680 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HaCaT cell | - |
Homo sapiens | - |
keratinocyte cell line | MCA3D (non-tumorigenic keratinocytes) highest IKK alpha expression, PDVC57 (moderately carcinogenic keratinocytes) show an important reduction in IKK alpha expression, HACa4 cells (highly tumorigenic) expression of IKK alpha is almost absent | Mus musculus | - |
squamous cell carcinoma cell | in human acantholytic squamous cell carcinoma IKKalpha and E-cadherin are strongly expressed, with absence of keratins K1 and K10, usually co-expressed with IKKalpha and E-cadherin | Homo sapiens | - |
squamous cell carcinoma cell line | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
IKKalpha | - |
Homo sapiens |
IKKalpha | - |
Mus musculus |