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Literature summary for 2.7.11.10 extracted from

  • Moreno-Maldonado, R.; Ramirez, A.; Navarro, M.; Fernandez-Acenero, M.J.; Villanueva, C.; Page, A.; Jorcano, J.L.; Bravo, A.; Llanos Casanova, M.
    IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas (2008), Cell Cycle, 7, 2021-2029.
    View publication on PubMed

Application

Application Comment Organism
medicine IKKalpha is responsible for the development of acantholytic squamous cell carcinoma (ASCC), a human SCC variant Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enhanced IKKalpha expression increases both early and terminal differentiation of human keratinocytes through an E-cadherin-dependent mechanism Homo sapiens
additional information increased expression of IKKalpha in mouse tumorigenic epidermal cells (PDVC57) leads to changes in the differentiation pattern of the resulting squamous cell carcinomas, originating a distinct histological variant that resembles the human acantholytic squamous cell carcinomas (ASCC) variant Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens O15111
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Mus musculus Q60680
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Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell
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Homo sapiens
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keratinocyte cell line MCA3D (non-tumorigenic keratinocytes) highest IKK alpha expression, PDVC57 (moderately carcinogenic keratinocytes) show an important reduction in IKK alpha expression, HACa4 cells (highly tumorigenic) expression of IKK alpha is almost absent Mus musculus
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squamous cell carcinoma cell in human acantholytic squamous cell carcinoma IKKalpha and E-cadherin are strongly expressed, with absence of keratins K1 and K10, usually co-expressed with IKKalpha and E-cadherin Homo sapiens
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squamous cell carcinoma cell line
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Homo sapiens
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Synonyms

Synonyms Comment Organism
IKKalpha
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Homo sapiens
IKKalpha
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Mus musculus