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Literature summary for 2.7.11.10 extracted from

  • Bibeau-Poirier, A.; Gravel, S.P.; Clement, J.F.; Rolland, S.; Rodier, G.; Coulombe, P.; Hiscott, J.; Grandvaux, N.; Meloche, S.; Servant, M.J.
    Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation (2006), J. Immunol., 177, 5059-5067.
    View publication on PubMed
Search for more literature for 2.7.11.10

Protein Variants

Protein Variants Comment Organism
additional information transfection of siRNA duplexes directed against IKKi and TBK1 downregulates the expression levels of both kinase isoforms by about 70% Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus IKK-related kinases tank-binding kinase 1 TBK1/IKKi and cullin-based ubiquitin ligases are involved in IFN regulatory factor-3, IRF-3, phosphorylation, activation, and degradation, IRF-3 activation is induced by viral infection, e.g. by HCMV, molecular mechanisms, detailed overview ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast mouse embryonic fibrblasts MEF Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information IKK-related kinases tank-binding kinase 1 TBK1/IKKi and cullin-based ubiquitin ligases are involved in IFN regulatory factor-3, IRF-3, phosphorylation, activation, and degradation, IRF-3 activation is induced by viral infection, e.g. by HCMV, molecular mechanisms, detailed overview Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
IKK
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 Mus musculus