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Literature summary for 2.7.11.10 extracted from
- Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression (2003), Nature, 423, 655-659.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | cytokine-induced activation of IKK, e.g. by TNFalpha, required for NFkappaB activation, leads to rapid degradation of IkappaB | Homo sapiens | |
| additional information | TNF-alpha induced association of IKK-alpha with p65 and CBP | Mus musculus | |
| TNFalpha | activates histone H3 phosphorylation activity, TNFalpha-induced activation of IKK-beta but not IKK-alpha leads to rapid NFkappaB activation and subsequent degradation of IkappaB | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of Myc-tagged IKK-alpha or IKK-beta in embryonic fibroblasts MEF cell line | Mus musculus |
| expression of Myc-tagged IKK-alpha or IKK-beta in mouse embryonic fibroblasts MEF cell line | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | IKK-beta and IKK-alpha | Mus musculus | 5737 | - |
| cytoplasm | IKK-beta and IKK-alpha | Homo sapiens | 5737 | - |
| nucleus | IKK-alpha | Mus musculus | 5634 | - |
| nucleus | IKK-alpha | Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [histone H3 protein] | Mus musculus | histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression | ADP + [histone H3 phosphoprotein] | - |
? |  |
| ATP + [histone H3 protein] | Homo sapiens | histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression | ADP + [histone H3 phosphoprotein] | - |
? | |
| ATP + [IkappaB protein] | Mus musculus | - |
ADP + [IkappaB phosphoprotein] | - |
? | |
| ATP + [IkappaB protein] | Homo sapiens | - |
ADP + [IkappaB phosphoprotein] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
IKK-alpha and IKK-beta | - |
| Mus musculus | - |
IKK-alpha and IKK-beta | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Mus musculus | - |
| fibroblast | embryonic | Mus musculus | - |
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [histone H3 protein] | - |
Homo sapiens | ADP + [histone H3 phosphoprotein] | - |
? | |
| ATP + [histone H3 protein] | histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression | Mus musculus | ADP + [histone H3 phosphoprotein] | - |
? | |
| ATP + [histone H3 protein] | histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression | Homo sapiens | ADP + [histone H3 phosphoprotein] | - |
? | |
| ATP + [histone H3 protein] | phosphorylation at Ser10 by IKK-alpha | Mus musculus | ADP + [histone H3 phosphoprotein] | - |
? | |
| ATP + [IkappaB protein] | - |
Mus musculus | ADP + [IkappaB phosphoprotein] | - |
? | |
| ATP + [IkappaB protein] | - |
Homo sapiens | ADP + [IkappaB phosphoprotein] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IKK | - |
Mus musculus |
| IKK | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
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