Any feedback?
Literature summary for 2.7.11.10 extracted from
- HSCARG inhibits activation of NF-kappaB by interacting with IkappaB kinase-beta (2009), J. Cell Sci., 122, 4081-4088.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| IKKalpha, IKKbeta and IKKgamma, cloned into pRK-FLAG or pRK-HA, are used, IKKbeta fragments, aa1-398, aa399-576, aa577-756, are inserted into the vector pRK-FLAG | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| protein HSCARG | or NMRAL1, NmrA-like family domain-containing protein 1, inhibits the phosphorylation of IKKbeta | Homo sapiens | |
| shRNA | - |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [IkappaB protein] | Homo sapiens | - |
ADP + [IkappaB phosphoprotein] | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| nuclear and cytoplasmic extracts are prepared | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293T cell | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [IkappaB protein] | - |
Homo sapiens | ADP + [IkappaB phosphoprotein] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IkappaB kinase-beta | - |
Homo sapiens |
| IKKbeta | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
