Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | IKKbeta is activated by phosphorylation at Ser171 and Ser181 of the activation loop | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of FLAG- or HA-tagged wild-type and mutant IKKbeta in HEK-293 and HeLa cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C179A | site-directed mutagenesis of IKKbeta at the activation loop, the mutant shows reduced activation and activity compared to the wild-type enzyme, which is not restorable by TNF stimulation, activity of the mutant is partially recovered when its phosphorylation is enforced by coexpression with mitogen-activated protein kinase kinase kinases such as NF-kappaB inducing kinase, NIK, and MAPK/extracellular signal-regulated kinase kinase kinase 1, MEKK1, or when the serine residues are replaced with phospho-mimetic glutamate, the mutant is normal in dimer formation, while its activity abnormally responds to the change in the concentration of substrate ATP, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antirheumatic gold compound | inhibition of IKKbeta | Homo sapiens | |
arsenite | inhibition of IKKbeta | Homo sapiens | |
cyclopentenone prostaglandins | inhibition of IKKbeta | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | IKKbeta subunit of IKK complex is essential for the activation of NF-kappaB in response to various proinflammatory signals, Cys179 of IkappaB kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | IKKbeta is activated by phosphorylation at Ser171 and Ser181 of the activation loop | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | IKKbeta subunit of IKK complex is essential for the activation of NF-kappaB in response to various proinflammatory signals, Cys179 of IkappaB kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IKK | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | binding involves activation loop Cys179 | Homo sapiens |