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Literature summary for 2.7.11.10 extracted from

  • Byun, M.S.; Choi, J.; Jue, D.M.
    Cysteine-179 of IkappaB kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines (2006), Exp. Mol. Med., 38, 546-552.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information IKKbeta is activated by phosphorylation at Ser171 and Ser181 of the activation loop Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of FLAG- or HA-tagged wild-type and mutant IKKbeta in HEK-293 and HeLa cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C179A site-directed mutagenesis of IKKbeta at the activation loop, the mutant shows reduced activation and activity compared to the wild-type enzyme, which is not restorable by TNF stimulation, activity of the mutant is partially recovered when its phosphorylation is enforced by coexpression with mitogen-activated protein kinase kinase kinases such as NF-kappaB inducing kinase, NIK, and MAPK/extracellular signal-regulated kinase kinase kinase 1, MEKK1, or when the serine residues are replaced with phospho-mimetic glutamate, the mutant is normal in dimer formation, while its activity abnormally responds to the change in the concentration of substrate ATP, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
antirheumatic gold compound inhibition of IKKbeta Homo sapiens
arsenite inhibition of IKKbeta Homo sapiens
cyclopentenone prostaglandins inhibition of IKKbeta Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens IKKbeta subunit of IKK complex is essential for the activation of NF-kappaB in response to various proinflammatory signals, Cys179 of IkappaB kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein IKKbeta is activated by phosphorylation at Ser171 and Ser181 of the activation loop Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information IKKbeta subunit of IKK complex is essential for the activation of NF-kappaB in response to various proinflammatory signals, Cys179 of IkappaB kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines, overview Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
IKK
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP binding involves activation loop Cys179 Homo sapiens